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Volume 22, Issue 4
  • ISSN: 1570-162X
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Abstract

Background

Vitamin D deficiency and/or insufficiency (hypovitaminosis D) has been associated with several disorders including autoimmune diseases, like type 1 diabetes mellitus; cardiovascular diseases; neoplasms; obesity; insulin resistance, and type 2 diabetes mellitus. This problem is common in southern European countries, especially in elderly and institutionalized persons. In HIV-infected individuals, hypovitaminosis D has been correlated with various complications like tuberculosis, hyperparathyroidism, bone mass loss, premature atherosclerosis, and systemic arterial hypertension, deterioration of immune function, progression of the disease and overall mortality.

Objective

The objective of this study was to examine the prevalence and causes of hypovitaminosis D in a cohort of Greek HIV-infected patients, as well as possible complications associated with it.

Methods

All patients attending our HIV unit for a period of 5 months were included in this study. Vitamin D status, medical anamnes, and laboratory tests were obtained at baseline; patients were followed for 3 years and HIV-related complications were noted. No patient received vitamin D supplementation during the follow-up period.

Results

Hypovitaminosis D was common, with 83.7% of the patients showing levels below 30 ng/dl and 55.4% below 20 ng/dl. After multivariable analysis, age and duration of treatment were the only significant factors for low vitamin D levels. During follow-up, 26 patients exhibited a total of 34 HIV-related complications, the most common being pneumonocystis jiroveci pneumonia (PCP). Hypovitaminosis D showed a positive correlation with overall complications, PCP as well as wasting syndrome.

Conclusion

Overall, our study shows that hypovitaminosis D is common in HIV-infected individuals and should probably be treated as soon as possible to protect these patients from serious HIV-related complications like PCP or wasting syndrome.

© 2024 Bentham Science Publishers
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2024-07-01
2024-11-19

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References

  1. AdamsJ.S. HewisonM. Update in vitamin D.J. Clin. Endocrinol. Metab.201095247147810.1210/jc.2009‑177320133466
     [Google Scholar]
  2. BikleD. Nonclassic actions of vitamin D.J. Clin. Endocrinol. Metab.2009941263410.1210/jc.2008‑145418854395
     [Google Scholar]
  3. OyedeleT. AdeyemiO.M. High prevalence of vitamin D deficiency in HIV-infected adults: What are the future research questions?Curr. HIV/AIDS Rep.2012911410.1007/s11904‑011‑0101‑922187389
     [Google Scholar]
  4. SaraivaG.L. CendorogloM.S. RamosL.R. Prevalência da deficiência, insuficiência de vitamina D e hiperparatireoidismo secundário em idosos institucionalizados e moradores na comunidade da cidade de São Paulo, Brasil.Arq Bras Endocrinol Metab.201051312
     [Google Scholar]
  5. CanutoJ.M.P. CanutoV.M.P. LimaM.H.A. OmenaA.L.C.S. MoraisT.M.L. PaivaA.M. DinizE.T. AlmeidaD.J.F.T. FerreiraS.M.S. Risk factors associated with hypovitaminosis D in HIV/aids-infected adults.Arch. Endocrinol. Metab.2015591344110.1590/2359‑399700000000725926112
     [Google Scholar]
  6. AmreinK. ScherklM. HoffmannM. Neuwersch-SommereggerS. KöstenbergerM. Tmava BerishaA. MartucciG. PilzS. MalleO. Vitamin D deficiency 2.0: An update on the current status worldwide.Eur. J. Clin. Nutr.202074111498151310.1038/s41430‑020‑0558‑y31959942
     [Google Scholar]
  7. ChoiA.I. LoJ.C. MulliganK. SchnellA. KalapusS.C. LiY. HuntP.W. MartinJ.N. DeeksS.G. HsueP.Y. Association of vitamin D insufficiency with carotid intima-media thickness in HIV-infected persons.Clin. Infect. Dis.201152794194410.1093/cid/ciq23921273298
     [Google Scholar]
  8. Greene-FinestoneL.S. BergerC. de GrohM. HanleyD.A. HidiroglouN. SarafinK. PoliquinS. KriegerJ. RichardsJ.B. GoltzmanD. 25-Hydroxyvitamin D in Canadian adults: Biological, environmental, and behavioral correlates.Osteoporos. Int.20112251389139910.1007/s00198‑010‑1362‑720730415
     [Google Scholar]
  9. LaiY.C. ChenY.H. LiangF.W. WuY.C. WangJ.J. LimS.W. HoC.H. Determinants of cancer incidence and mortality among people with vitamin D deficiency: An epidemiology study using a real-world population database.Front. Nutr.202310129406610.3389/fnut.2023.129406638130443
     [Google Scholar]
  10. HendriksS. RansonJ.M. PeetoomK. Risk factors for young-onset dementia in the UK Biobank.JAMA Neurol.202381213414210.1001/jamaneurol.2023.492938147328
     [Google Scholar]
  11. SamantaI. PatilD.J. MoreC.B. Assessment of vitamin D levels in patients with oral potentially malignant disorders and oral squamous cell carcinoma-A cross-sectional study.J. Oral Biol. Craniofac. Res.2024141273210.1016/j.jobcr.2023.11.00538130424
     [Google Scholar]
  12. CamargoC.A.Jr SchaumbergD.A. FriedenbergG. DushkesR. GlynnR.J. GoldD.R. MoraS. LeeI.M. BuringJ.E. MansonJ.A.E. Effect of daily vitamin D supplementation on risk of upper respiratory infection in older adults: A randomized controlled trial. Clin Infect Dis.Clin. Infect. Dis.20247851162116910.1093/cid/ciad770
     [Google Scholar]
  13. JiangL. ZhiS. WeiC. RongZ. ZhangH. Serum 25(OH)D levels are associated with disease activity and renal involvement in initial-onset childhood systemic lupus erythematosus.Front Pediatr.202311125259410.3389/fped.2023.125259438111622
     [Google Scholar]
  14. AbukannaA.M.A. AlanaziR.F.A. AlruwailiF.S. AlayyashiA.Z.M. AlanziF. VitaminD. Vitamin D deficiency as a risk factor for diabetes and poor glycemic control in Saudi Arabia: A systematic review.Cureus20231511e4857710.7759/cureus.4857738073984
     [Google Scholar]
  15. KimM.S. LeeJ.S. ChungS.J. SohY. Association between vitamin D and short-term functional outcomes in acute ischemic stroke.Nutrients20231523495710.3390/nu1523495738068815
     [Google Scholar]
  16. LiuJ. TianC. TangY. GengB. Associations of the serum vitamin D with mortality in postmenopausal women.Clin. Nutr.202443121121710.1016/j.clnu.2023.11.04138086258
     [Google Scholar]
  17. ChenC.W. HanY.Y. HwangJ.S. RizzoM. YamashitaS. HsuS.H. SuT.C. Association between adequate serum 25(OH)D levels and atherogenic dyslipidemia in young adults.J. Atheroscler. Thromb.202331552453910.5551/jat.6452338057082
     [Google Scholar]
  18. AagaardK Møllegaard JepsenJR SevelstedA High-dose vitamin D3 supplementation in pregnancy and risk of neurodevelopmental disorders in the children at age 10: A randomized clinical trial.Am J Clin Nutr2024119236237010.1016/j.ajcnut.2023.12.002
     [Google Scholar]
  19. MassaA Isasi-FusterA RequenaC Manrique-SilvaE KumarR NagoreE Nodular type but not vitamin D Levels increases the risk of second primary cancers in melanoma patients: An observational study of 663 patients.Actas Dermosifiliogr20241152T143T14910.1016/j.ad.2023.10.038
     [Google Scholar]
  20. ArnqvistH.J. LeandersonP. SpångeusA. Vitamin D status in longstanding type 1 diabetes and controls. Association with upper extremity impairments.Ups. J. Med. Sci.202312810.48101/ujms.v128.988838084202
     [Google Scholar]
  21. BoggessK.A. EspinolaJ.A. MossK. BeckJ. OffenbacherS. CamargoC.A.Jr Vitamin D status and periodontal disease among pregnant women.J. Periodontol.201182219520010.1902/jop.2010.10038420809861
     [Google Scholar]
  22. HaugenM. BrantsæterA.L. TrogstadL. AlexanderJ. RothC. MagnusP. MeltzerH.M. Vitamin D supplementation and reduced risk of preeclampsia in nulliparous women.Epidemiology200920572072610.1097/EDE.0b013e3181a70f0819451820
     [Google Scholar]
  23. MaghbooliZ. Hossein-nezhadA. KarimiF. ShafaeiA.R. LarijaniB. Correlation between vitamin D 3 deficiency and insulin resistance in pregnancy.Diabetes Metab. Res. Rev.2008241273210.1002/dmrr.73717607661
     [Google Scholar]
  24. BodnarL.M. CatovJ.M. ZmudaJ.M. CooperM.E. ParrottM.S. RobertsJ.M. MarazitaM.L. SimhanH.N. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women.J. Nutr.20101405999100610.3945/jn.109.11963620200114
     [Google Scholar]
  25. ViljakainenH.T. KorhonenT. HytinanttiT. LaitinenE.K.A. AnderssonS. MäkitieO. Lamberg-AllardtC. Maternal vitamin D status affects bone growth in early childhood—a prospective cohort study.Osteoporos. Int.201122388389110.1007/s00198‑010‑1499‑421153404
     [Google Scholar]
  26. BelderbosM.E. HoubenM.L. WilbrinkB. LentjesE. BloemenE.M. KimpenJ.L.L. RoversM. BontL. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis.Pediatrics20111276e1513e152010.1542/peds.2010‑305421555499
     [Google Scholar]
  27. Díaz-LópezA Paz-GranielI Alonso-SanzR Marqués BalderoC Mateos GilC Arija ValV. Vitamin D deficiency in primary health care users at risk in Spain.Nutr Hosp20213851058106710.20960/nh.03565
     [Google Scholar]
  28. Díaz-RizzoloD.A. KostovB. GomisR. Sisó-AlmirallA. Paradoxical suboptimal vitamin D levels in a Mediterranean area: A population-based study.Sci. Rep.20221211964510.1038/s41598‑022‑23416‑136385623
     [Google Scholar]
  29. SouberbielleJ.C. MassartC. Brailly-TabardS. CavalierE. ChansonP. Prevalence and determinants of vitamin D deficiency in healthy French adults: The VARIETE study.Endocrine201653254355010.1007/s12020‑016‑0960‑327106800
     [Google Scholar]
  30. GaleazziT. QuattriniS. PjetrajD. GattiS. MonachesiC. FranceschiniE. MarinelliL. CatassiG.N. LionettiE. CatassiC. Vitamin D status in healthy Italian school-age children: A single-center cross-sectional study.Ital. J. Pediatr.20234912710.1186/s13052‑023‑01422‑x36814347
     [Google Scholar]
  31. MorsilliO. GuerrieroR. PalmieriL. Lo NoceC. ZellerT. BlankenbergS. Di LonardoA. VannucchiS. GabbianelliM. DonfrancescoC. Vitamin D status in a rural italian population.Reports202151110.3390/reports5010001
     [Google Scholar]
  32. CapuanoR. MarcheseF. SicaR. CapuanoE. ManiliaM. IannoneA.G. D’AmbrosioA. BiseccoA. TedeschiG. GalloA. CapuanoV. Epidemiologic data of vitamin D deficiency and its implication in cardio-cerebrovascular risk in a Southern Italian Population.J. Nutr. Metab.202120211810.1155/2021/555022234211785
     [Google Scholar]
  33. ChallaA. NtourntoufiA. CholevasV. BitsoriM. GalanakisE. AndronikouS. Breastfeeding and vitamin D status in Greece during the first 6 months of life.Eur. J. Pediatr.20051641272472910.1007/s00431‑005‑1757‑116143866
     [Google Scholar]
  34. LapatsanisD. MoulasA. CholevasV. SoukakosP. PapadopoulouZ.L. ChallaA. VitaminD. Vitamin D: A necessity for children and adolescents in Greece.Calcif. Tissue Int.200577634835510.1007/s00223‑004‑0096‑y16362463
     [Google Scholar]
  35. XydaS.E. KotsaK. DoumasA. PapanastasiouE. GaryfallosA.A. SamoutisG. Could the majority of the greek and cypriot population be Vitamin D deficient?Nutrients20221418377810.3390/nu1418377836145154
     [Google Scholar]
  36. BouloukakiI. MarkakisM. PateliR. LyronisI. SchizaS. TsiligianniI. Vitamin D levels in primary care patients: Correlations with clinical, seasonal, and quality-of-life parameters.Fam. Pract.202239467868410.1093/fampra/cmac01235325110
     [Google Scholar]
  37. MehtaS. MugusiF.M. SpiegelmanD. VillamorE. FinkelsteinJ.L. HertzmarkE. GiovannucciE.L. MsamangaG.I. FawziW.W. Vitamin D status and its association with morbidity including wasting and opportunistic illnesses in HIV-infected women in Tanzania.AIDS Patient Care STDS2011251057958510.1089/apc.2011.018221916603
     [Google Scholar]
  38. SzepZ. GuaraldiG. ShahS.S. Lo ReV.III RatcliffeS.J. OrlandoG. CarliF. RossiR. RochiraV. TebasP. Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection.AIDS201125452552910.1097/QAD.0b013e328342fdfd21178753
     [Google Scholar]
  39. HilemanC.O. OvertonE.T. McComseyG.A. Vitamin D and bone loss in HIV.Curr. Opin. HIV AIDS201611327728410.1097/COH.000000000000027226890209
     [Google Scholar]
  40. NguyenH.S. Van TranK. ChenS.Y. TamK.W. A systematic review and meta-analysis of randomized controlled trials of the effects of vitamin D supplementation on children and young adults with HIV infection.J. Nutr.2023153113814710.1016/j.tjnut.2022.10.00836913447
     [Google Scholar]
  41. ViardJP SouberbielleJC KirkO Vitamin D and clinical disease progression in HIV infection: Results from the EuroSIDA study.AIDS20112510130515
     [Google Scholar]
  42. Jiménez-SousaM.Á. MartínezI. MedranoL.M. Fernández-RodríguezA. ResinoS. Vitamin D in human immunodeficiency virus infection: Influence on immunity and disease.Front. Immunol.2018945810.3389/fimmu.2018.0045829593721
     [Google Scholar]
  43. ShepherdL. SouberbielleJ.C. BastardJ.P. FellahiS. CapeauJ. ReekieJ. ReissP. BlaxhultA. BickelM. LeenC. KirkO. LundgrenJ.D. MocroftA. ViardJ.P. Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons.J. Infect. Dis.2014210223424310.1093/infdis/jiu07424493824
     [Google Scholar]
  44. VermaP. ShrivastavaA. SiddiquiS.A. YadavR.K. SinghM.V. TripathiA. MauryaM. MishraN. Effect of vitamin D supplementation on CD4 count in HIV-infected children and adolescents in North India: A non-randomized comparative study.J. Trop. Pediatr.2022685fmac06610.1093/tropej/fmac06635944184
     [Google Scholar]
  45. LeeS. LeeJ.E. LeeS.O. SimY.K. LeeS.H. Influence of vitamin D deficiency on the development of opportunistic infection in people living with HIV/AIDS (PWHAs).J. Am. Coll. Nutr.202140654555010.1080/07315724.2020.180504332790581
     [Google Scholar]
  46. CalzaL. BorderiM. GranozziB. MalossoP. PancaldiL. BonI. ReM.C. Vitamin D insufficiency is associated with subclinical atherosclerosis in HIV-1-infected patients on combination antiretroviral therapy.HIV Res. Clin. Pract.201920613113910.1080/25787489.2020.172474932065065
     [Google Scholar]
  47. CheruL.T. SaylorC.F. FitchK.V. LoobyS.E. LuM. HoffmannU. StanleyT.L. LoJ. Low vitamin D is associated with coronary atherosclerosis in women with HIV.Antivir. Ther.201924750551210.3851/IMP333631742564
     [Google Scholar]
  48. WelzT. ChildsK. IbrahimF. PoultonM. TaylorC.B. MonizC.F. PostF.A. Efavirenz is associated with severe vitamin D deficiency and increased alkaline phosphatase.AIDS201024121923192810.1097/QAD.0b013e32833c328120588161
     [Google Scholar]
  49. NylénH. HabtewoldA. MakonnenE. YimerG. BertilssonL. BurhenneJ. DiczfalusyU. AklilluE. Prevalence and risk factors for efavirenz-based antiretroviral treatment–associated severe vitamin D deficiency.Medicine (Baltimore)20169534e463110.1097/MD.000000000000463127559961
     [Google Scholar]
  50. HaversF.P. DetrickB. CardosoS.W. BerendesS. LamaJ.R. SugandhavesaP. MwelaseN.H. CampbellT.B. GuptaA. Change in vitamin d levels occurs early after antiretroviral therapy initiation and depends on treatment regimen in resource-limited settings.PLoS One201494e9516410.1371/journal.pone.009516424752177
     [Google Scholar]
  51. LegeaiC. VigourouxC. SouberbielleJ.C. BouchaudO. BoufassaF. BastardJ.P. CarlierR. CapeauJ. GoujardC. MeyerL. ViardJ.P. Associations between 25-hydroxyvitamin D and immunologic, metabolic, inflammatory markers in treatment-naive HIV-infected persons: The ANRS CO9 «COPANA» cohort study.PLoS One201389e7486810.1371/journal.pone.007486824058636
     [Google Scholar]
  52. DaoC.N. PatelP. OvertonE.T. RhameF. PalsS.L. JohnsonC. BushT. BrooksJ.T. Low vitamin D among HIV-infected adults: Prevalence of and risk factors for low vitamin D Levels in a cohort of HIV-infected adults and comparison to prevalence among adults in the US general population.Clin. Infect. Dis.201152339640510.1093/cid/ciq15821217186
     [Google Scholar]
  53. VisuthranukulJ. PhansueaP. BuranakityanonP. LerdrungrojP. YamasmithE. Prevalence and risk factors of vitamin D deficiency among living with HIV adults receiving antiretroviral treatment in tropical area: Cross-sectional study.Heliyon202399e1953710.1016/j.heliyon.2023.e1953737809448
     [Google Scholar]
  54. WangY. HuangX. WuY. LiA. TianY. RenM. LiZ. ZhangT. WuH. WangW. Increased risk of vitamin D deficiency among HIV-infected individuals: A systematic review and meta-analysis.Front. Nutr.2021872203210.3389/fnut.2021.72203234490331
     [Google Scholar]
  55. KanwalW. RehmanA. High prevalence of vitamin D deficiency in HIV-infected individuals in comparison with the general population across Punjab province, Pakistan.Saudi J. Biol. Sci.202330110348410.1016/j.sjbs.2022.10348436387030
     [Google Scholar]
  56. HavensP.L. TamhaneA. StephensenC.B. SchusterG.U. GordonC.M. LiuN. WilsonC.M. HosekS.G. AndersonP.L. KapogiannisB.G. MulliganK. Short communication: Association of vitamin D Insufficiency and protective tenofovir diphosphate concentrations with bone toxicity in adolescent boys and young men using tenofovir disoproxil fumarate/emtricitabine for HIV pre-exposure prophylaxis.AIDS Res. Hum. Retroviruses201935212312810.1089/aid.2018.009630280906
     [Google Scholar]
  57. CalzaL. di PietroG. ColangeliV. BorderiM. ZaghiI. MalossoP. BonI. ReM.C. VialeP. Factors associated with vitamin D deficiency in HIV-1 infected patients on combination antiretroviral therapy: A case-control study.New Microbiol.201942314514931305932
     [Google Scholar]
  58. MikułaT. SapułaM. SuchaczM.M. KozłowskaJ. KrankowskaD. StańczakW. Wiercińska-DrapałoA. Risk factors of hypovitaminosis D in HIV-infected patients on suppressive antiretroviral therapy.AIDS Res. Hum. Retroviruses202036867668010.1089/aid.2019.002032408752
     [Google Scholar]
  59. ArpadiS.M. ShiauS. StrehlauR. PatelF. MbeteN. McMahonD.J. KaufmanJ.J. CoovadiaA. KuhnL. YinM.T. Efavirenz is associated with higher bone mass in South African children with HIV.AIDS201630162459246710.1097/QAD.000000000000120427427876
     [Google Scholar]
  60. SchneiderE. WhitmoreS. GlynnK.M. DominguezK. MitschA. McKennaM.T. Revised surveillance case definitions for HIV infection among adults, adolescents, and children aged <18 months and for HIV infection and AIDS among children aged 18 months to <13 years-United States, 2008.MMWR Recomm. Rep.200857RR-1011219052530
     [Google Scholar]
  61. TheodorouM. SerstéT. Van GossumM. DewitS. Factors associated with vitamin D deficiency in a population of 2044 HIV-infected patients.Clin. Nutr.201433227427910.1016/j.clnu.2013.04.01823680190
     [Google Scholar]
  62. CerveroM. AgudJ.L. García-LacalleC. AlcázarV. TorresR. JusdadoJ.J. Moreno GuillénS. Prevalence of vitamin D deficiency and its related risk factor in a Spanish cohort of adult HIV-infected patients: Effects of antiretroviral therapy.AIDS Res. Hum. Retroviruses201228996397110.1089/aid.2011.024422242918
     [Google Scholar]
  63. CrutchleyRD GatheJJr MayberryC TrieuA AbughoshS GareyKW Risk factors for vitamin D deficiency in HIV-infected patients in the south central United States.AIDS Res. Hum. Retroviruses20122854549
     [Google Scholar]
  64. AzizM LivakB. Burke-MillerJ. FrenchA.L. GlesbyM.J. SharmaA. YoungM VillacresM.C. TienPC GolubET CohenPC moazMH AdeyemiOM Vitamin D insufficiency may impair CD4 recovery among Women's Interagency HIV Study participants with advanced disease on HAART.AIDS2013274573810.1371/journal.pone.022287831550271
     [Google Scholar]
  65. EzeamamaA.E. GuwatuddeD. WangM. BagendaD. KyeyuneR. SudfeldC. ManabeY.C. FawziW.W. Vitamin-D deficiency impairs CD4+T-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: A longitudinal study.Clin. Nutr.20163551110111710.1016/j.clnu.2015.08.00726371397
     [Google Scholar]
  66. KimJ.H. GandhiV. PsevdosG.Jr EspinozaF. ParkJ. SharpV. Evaluation of vitamin D levels among HIV-infected patients in New York City.AIDS Res. Hum. Retroviruses201228323524110.1089/aid.2011.004021644847
     [Google Scholar]
  67. NugmanovaZ. PatelN. AkhmetovaG.M. KurmangalievaG.S. AbdumananovaM.K. AkanovA.A. KovtunenkoN.G. McNuttL.A. Relationship between vitamin D and human immunodeficiency virus (HIV) viral load among HIV-infected patients in Kazakhstan.J. Infect. Dev. Ctries.20159111277128310.3855/jidc.680826623638
     [Google Scholar]
  68. FlauzinoT. SimaoA.N.C. de AlmeidaE.R.D. MorimotoH.K. OliveiraS.R. AlfieriD.F. UedaL.T. DichiI. ReicheE.M.V. Association between vitamin D status, oxidative stress biomarkers and viral load in Human Immunodeficiency Virus Type 1 infection.Curr. HIV Res.201715533634428990534
     [Google Scholar]
  69. Lozano-RosA. Martínez-GinésM.L. García-DomínguezJ.M. Salvador-MartínS. Goicochea-BriceñoH. CuelloJ.P. Meldaña-RiveraA. Higueras-HernándezY. Sanjurjo-SáezM. Álvarez-Sala-WaltherL.A. López-FernándezL.A. Changes in the expression of TGF-beta regulatory pathway genes induced by vitamin D in patients with relapsing-remitting multiple sclerosis.Int. J. Mol. Sci.202324191444710.3390/ijms24191444737833895
     [Google Scholar]
  70. GunvilleC. MouraniP. GindeA. The role of vitamin D in prevention and treatment of infection.Inflamm. Allergy Drug Targets201312423924510.2174/1871528111312999004623782205
     [Google Scholar]
  71. AdamsJ.S. HewisonM. Unexpected actions of vitamin D: New perspectives on the regulation of innate and adaptive immunity.Nat. Clin. Pract. Endocrinol. Metab.200842809010.1038/ncpendmet071618212810
     [Google Scholar]
  72. EdfeldtK. LiuP.T. ChunR. FabriM. SchenkM. WheelwrightM. KeeganC. KrutzikS.R. AdamsJ.S. HewisonM. ModlinR.L. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism.Proc. Natl. Acad. Sci. USA201010752225932259810.1073/pnas.101162410821149724
     [Google Scholar]
  73. SudfeldC.R. GiovannucciE.L. IsanakaS. AboudS. MugusiF.M. WangM. ChalamillaG. FawziW.W. Vitamin D status and incidence of pulmonary tuberculosis, opportunistic infections, and wasting among HIV-infected Tanzanian adults initiating antiretroviral therapy.J. Infect. Dis.2013207337838510.1093/infdis/jis69323162137
     [Google Scholar]
  74. ManionM. HullsiekK.H. WilsonE.M.P. RhameF. KojicE. GibsonD. HammerJ. PatelP. BrooksJ.T. BakerJ.V. SeretiI. Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons.PLoS One2017125e017551710.1371/journal.pone.017551728464004
     [Google Scholar]
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Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study
Current HIV Research 22, 240 (2024); https://doi.org/10.2174/011570162X302844240605104855
/content/journals/chr/10.2174/011570162X302844240605104855
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  • Article Type:     Research Article
Keyword(s): HIV; hypovitaminosis D; immunodeficiency; pneumocystis jiroveci pneumonia; vitamin D; wasting syndrome
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