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Volume 22, Issue 5
  • ISSN: 1570-162X
  • E-ISSN: 1873-4251

Abstract

Background

COVID-19 has inevitably influenced health systems. HIV testing rates have been reduced, and access to antiretroviral treatment has been scaled down. We evaluated the impact of COVID-19 on the management of people living with HIV (PLWH) in Türkiye.

Methods

We conducted a cross-sectional study in three tertiary care hospitals. We compared the baseline characteristics at the first visit and viral suppression rates at the 24th week of new HIV diagnoses during the pandemic with those during the previous two years. To observe the effect of the pandemic on people living with HIV who were already in care, we compared the metabolic and clinical parameters like weight, blood pressure, blood lipid levels, fasting glucose levels, and liver and renal function tests, of the same people before and during the pandemic.

Results

The first group included 380 cases (127 diagnosed during the pandemic and 253 diagnosed during the previous year). The demographic characteristics were similar. The newly diagnosed PLWH during the pandemic had significantly higher baseline HIV RNA levels (=0.005), a lower number of clinical visits (=0.0005), and a lower number of cases with undetectable viral loads at 24 weeks of treatment (=0.0005) than those diagnosed during the pre-pandemic period.

The second group included 261 individuals with a mean follow-up duration of 24.7 (SD± 3.5; min- max 12-144) months. The comparison of laboratory parameters revealed that in the post-pandemic period, virologic suppression was maintained at 90.1%, body mass index (=0,0001), total cholesterol (=0,0001), and LDL levels (=0,0001) increased significantly, and creatinine levels decreased significantly (=0,0001).

Conclusion

Our study showed that COVID-19 deteriorated the HIV management of PLHIV. Strengthening the medical infrastructure of basic services for PLWH is critical for future crises.

© 2024 Bentham Science Publishers
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2024-08-19
2025-01-10

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References

  1. Center for Systems Science and Engineering (CSSE) at Johns Hopkins University2020Available from: https://gisanddata.maps.arcgis.com/apps/dashboards/bda7594740fd40299423467b48e9ecf6 (accessed on 30-7-2024)
  2. JiangT. LiuC. ZhangJ. HuangX. XuJ. Impact of the COVID-19 pandemic on the UNAIDS Six 95% HIV control targets.Front. Med. (Lausanne)20229981805410.3389/fmed.2022.818054 35252256
     [Google Scholar]
  3. DarcisG. VairaD. MoutschenM. Impact of coronavirus pandemic and containment measures on HIV diagnosis.Epidemiol. Infect.2020148148e18510.1017/S0950268820001867 32829742
     [Google Scholar]
  4. RaoA. RucinskiK. JarrettB.A. Perceived interruptions to HIV prevention and treatment services associated with COVID-19 for gay, bisexual, and other men who have sex with men in 20 countries. JAIDS.J. Acquir. Immune Defic. Syndr.202187164465110.1097/QAI.0000000000002620 33443963
     [Google Scholar]
  5. WenlockR.D. ShillingfordC. MearJ. ChurchillD. VeraJ.H. DeanG. The impact of COVID‐19 on HIV testing in the UK’s first Fast‐Track HIV city.HIV Med.202223779079610.1111/hiv.13235 35094467
     [Google Scholar]
  6. MitchellH.D. VilaplanaT.G. MandalS. Effects of COVID-19 pandemic response on service provision for sexually transmitted infections, HIV, and Viral Hepatitis, England.Emerg. Infect. Dis.202228373974210.3201/eid2803.211998 35202537
     [Google Scholar]
  7. Van BeckhovenD. SerrienB. MontourcyM. Impact of COVID-19 on the Belgian HIV epidemic: slowdown of HIV transmission and testing and adaptation of care.BMC Infect. Dis.202222190110.1186/s12879‑022‑07879‑1 36463126
     [Google Scholar]
  8. HensleyK.S. JordansC.C.E. van KampenJ.J.A. Significant impact of coronavirus disease 2019 (COVID-19) on human immunodeficiency virus (HIV) care in hospitals affecting the first pillar of the HIV care continuum.Clin. Infect. Dis.202274352152410.1093/cid/ciab445 33993276
     [Google Scholar]
  9. SimõesD. StengaardA.R. CombsL. RabenD. Impact of the COVID-19 pandemic on testing services for HIV, viral hepatitis and sexually transmitted infections in the WHO European Region, March to August 2020.Euro Surveill.20202547200194310.2807/1560‑7917.ES.2020.25.47.2001943 33243354
     [Google Scholar]
  10. KaraosmanogluH.K. MeteB. GunduzA. Changing characteristics of patients living with HIV/AIDS after the COVID-19 pandemic in turkey.Curr. HIV Res.202220323624110.2174/1570162X20666220303103805 35240974
     [Google Scholar]
  11. UNAIDS2020Available from: https://www.unaids.org/en/resources/documents/2020/global-aids-report (accessed on 30-7-2024)
  12. UNAIDS 2022 Global AIDS Update 20222022Available from: https://reliefweb.int/report/world/danger-unaids-global-aids-update-2022-enru?gad_source=1gclid=CjwKCAjwnqK1BhBvEiwAi7o0X_9JRySA5l3qTd5fDK8ryHnJoqsBu2XVowUOiNLSlvE8y3onGfsTgxoCVrMQAvD_BwE (accessed on 15-7-2024)
  13. Ministry of Health, republic of turkey (MoH-TR)COVID-19 web page of the Republic of Turkey, Ministry of Health.2020Available from: https://covid19.saglik.gov.tr/TR-66301/covid-19-rehberi. html (accessed on 30-7-2024)
  14. PetersenE. Gökengi̇nD. SARS-CoV-2 epidemiology and control, different scenarios for Turkey.Turk. J. Med. Sci.202050SI-150951410.3906/sag‑2003‑260 32283894
     [Google Scholar]
  15. Public health department of ministry of health2022Available from: https://hsgm.saglik.gov.tr/tr/bulasicihastaliklar/hiv-aids/hiv-aids-liste/hiv-aids-istatislik.htm (accessed on 15-7-2024)
  16. WiessingL. SypsaV. AbagiuA.O. Impact of COVID-19 & response measures on HIV-HCV prevention services and social determinants in people who inject drugs in 13 sites with recent HIV outbreaks in europe, North America and Israel.AIDS Behav.20232741140115310.1007/s10461‑022‑03851‑x 36367613
     [Google Scholar]
  17. Niedźwiedzka-StadnikM. Nowakowska-RadziwonkaE. Marzec-BogusławskaA. HIV infections and AIDS in Poland in 2020.Przegl. Epidemiol.202276340242010.32394/pe.76.38 36524902
     [Google Scholar]
  18. Mäki-KoivistoV. SinikumpuS.P. JokelainenJ. Aho-LaukkanenE. JunttilaI.S. HuilajaL. Impact of COVID-19 pandemic on the incidence of sexually transmitted infections in northern finland in 2019 to 2022.Acta Derm. Venereol.2022102adv0079510.2340/actadv.v102.3401 36200507
     [Google Scholar]
  19. Niedźwiedzka-StadnikM. Nowakowska-RadziwonkaE. RosińskaM. Marzec-BogusławskaA. Changes in HIV testing trends in Poland during COVID-19 pandemic.Przegl. Epidemiol.202276225526610.32394/pe.76.25 36218184
     [Google Scholar]
  20. Toller ErausquinJ. TanR.K.J. UhlichM. the international sexual health and reproductive health during COVID-19 (I-SHARE) study: A multicountry analysis of adults from 30 countries prior to and during the initial coronavirus disease 2019 Wave.Clin. Infect. Dis.2022751e991e99910.1093/cid/ciac102 35136960
     [Google Scholar]
  21. LoghinI.I. VâţăA. MihaiI.F. Profile of newly diagnosed patients with HIV infection in north-eastern romania.Medicina (Kaunas)202359344010.3390/medicina59030440 36984440
     [Google Scholar]
  22. ReyniersT. RotsaertA. ThunissenE. Reduced sexual contacts with non-steady partners and less PrEP use among MSM in Belgium during the first weeks of the COVID-19 lockdown: results of an online survey.Sex. Transm. Infect.202197641441910.1136/sextrans‑2020‑054756 33172917
     [Google Scholar]
  23. HyndmanI. NugentD. WhitlockG.G. McOwanA. GiromettiN. COVID-19 restrictions and changing sexual behaviours in HIV-negative MSM at high risk of HIV infection in London, UK.Sex. Transm. Infect.202197752152410.1136/sextrans‑2020‑054768 33462118
     [Google Scholar]
  24. JacobL. SmithL. ButlerL. Challenges in the practice of sexual medicine in the time of COVID-19 in the United Kingdom.J. Sex. Med.20201771229123610.1016/j.jsxm.2020.05.001 32411271
     [Google Scholar]
  25. NadarzynskiT. NutlandW. SambaP. BayleyJ. WitzelT.C. The impact of first UK-wide lockdown (march–june 2020) on sexual behaviors in men and gender diverse people who have sex with men during the COVID-19 pandemic: A Cross-Sectional Survey.Arch. Sex. Behav.202352261762710.1007/s10508‑022‑02458‑6 36344786
     [Google Scholar]
  26. VanbaelenT. RotsaertA. JacobsB.K.M. Why do HIV pre-exposure prophylaxis users discontinue pre-exposure prophylaxis care? a mixed methods survey in a pre-exposure prophylaxis clinic in belgium.AIDS Patient Care STDS202236415916710.1089/apc.2021.0197 35438524
     [Google Scholar]
  27. PampatiS. EmrickK. SieglerA.J. JonesJ. Changes in sexual behavior, PrEP adherence, and access to sexual health services because of the COVID-19 pandemic among a cohort of PrEP-using MSM in the South.J. Acquir. Immune Defic. Syndr.202187163964310.1097/QAI.0000000000002640 33512848
     [Google Scholar]
  28. TrentM. PerinJ. YusufH. Understanding perceived risks and sexual behavior among adolescents and young adults during the COVID-19 Pandemic.J. Adolesc. Health202372581581810.1016/j.jadohealth.2022.11.249 36669959
     [Google Scholar]
  29. UhrmacherM. Skaletz-RorowskiA. NambiarS. HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: Results from a prospective observational study in Germany.Front. Public Health20221093020810.3389/fpubh.2022.930208 36091531
     [Google Scholar]
  30. HamusondeK. NiccaD. GünthardH.F. Triggers of change in sexual behavior among people with HIV: The swiss U = U statement and COVID-19 compared.J. Infect. Dis.2023227340741110.1093/infdis/jiac459 36408629
     [Google Scholar]
  31. KortenV GökenginD FincanciM Outcomes of initial antiretroviral treatment (ART) among recently diagnosed HIV patients in HIV‐TR cohort, 2011–2012J Int AIDS Soc2014174S3)(Suppl. 31967810.7448/IAS.17.4.19678 25397428
     [Google Scholar]
  32. ErdincF.S. DokuzoguzB. UnalS. Temporal trends in the epidemiology of HIV in Turkey.Curr. HIV Res.202018425826610.2174/1570162X18666200427223823 32342820
     [Google Scholar]
  33. MeteB. GunduzA. BolukcuS. HIV care in Istanbul, Turkey: How far is it from the UNAIDS 90–90–90 targets?Int. J. STD AIDS201930131298130310.1177/0956462419866342 31726930
     [Google Scholar]
  34. KaraosmanogluH.K. How does the COVID-19 pandemic affect the target 90-90-90?Curr. HIV Res.202119210310510.2174/1570162XMTExbODUl1 33243126
     [Google Scholar]
  35. SevgiD.Y. DemirbasN.D. Genc YamanI. Evaluation of the late presentation and associated factors of people living with HIV in Turkey.J. Med. Virol.2023955e2878110.1002/jmv.28781 37212337
     [Google Scholar]
  36. KowalskaJ.D. Skrzat-KlapaczyńskaA. BursaD. HIV care in times of the COVID-19 crisis — Where are we now in Central and Eastern Europe?Int. J. Infect. Dis.20209631131410.1016/j.ijid.2020.05.013 32413608
     [Google Scholar]
  37. Kuman TunçelÖ. PullukçuH. ErdemH.A. KurtaranB. TaşbakanS.E. Işikgöz TaşbakanM. COVID-19-related anxiety in people living with HIV: an online cross-sectional study.Turk. J. Med. Sci.20205081792180010.3906/sag‑2006‑140 32777899
     [Google Scholar]
  38. ErgenP. GörmezA. AnkaralıH. AydınÖ. Betül BaysalN. ÇağY. Anxiety and depression among people living with HIV during the COVID-19 pandemic: A Face-to-Face Survey from Turkey.Psychiatr. Danub.202335110311110.24869/psyd.2023.103 37060600
     [Google Scholar]
  39. KıllıN.E. BakırÇ.N. CanbazA.A. Resilience during the COVID-19 pandemic among people living with HIV: A cross-sectional study.Int. J. STD AIDS202334745746710.1177/09564624231156202 36820627
     [Google Scholar]
  40. PapadopoulosA. ThomasK. ProtopapasK. HIV treatment strategies across Central, Eastern and Southeastern Europe: New times, old problems.HIV Med.202324446247010.1111/hiv.13416 36196025
     [Google Scholar]
  41. HousseinM. InkayaA.Ç. BalciC. Frailty and sarcopenia among Turkish people aged 40 and above living with HIV.HIV Med.202223101061106810.1111/hiv.13311 35437886
     [Google Scholar]
  42. AlpE. BozkurtI. DoğanayM. Epidemiological and clinical characteristics of HIV/AIDS patients followed-up in Cappadocia region: 18 years experience.Mikrobiyol. Bul.2011451125136 21341167
     [Google Scholar]
  43. KortenV. GökenginD. ErenG. Trends and factors associated with modification or discontinuation of the initial antiretroviral regimen during the first year of treatment in the Turkish HIV-TR Cohort, 2011–2017.AIDS Res. Ther.2021181410.1186/s12981‑020‑00328‑6 33422112
     [Google Scholar]
  44. EACS Guidelines2023Available from: https://www.eacsociety.org/guidelines/eacs-guidelines/ (accessed on 30-7-2024)
  45. ShahS. HillA. Risks of metabolic syndrome and diabetes with integrase inhibitor-based therapy.Curr. Opin. Infect. Dis.2021341162410.1097/QCO.0000000000000695 33278177
     [Google Scholar]
  46. Turkish Statistical institute2023Available from: https://www.tuik.gov.tr/ (accessed on 30-7-2024)
  47. SezginO. AkpinarH. ÖzerB. TörünerM. BalK. BorS. The abdominal ultrasonography results of cappadocia cohort study of turkey reveals high prevalence of fatty liver.Turk. J. Gastroenterol.202334665266410.5152/tjg.2023.23067 37303246
     [Google Scholar]
  48. ShiA. DengJ. MaJ. Prevalence and risk factors of metabolic dysfunction-associated fatty liver disease with renal insufficiency in overweight/obese adults.Obes. Facts2023166548558Epub ahead of print10.1159/000533626 37640023
     [Google Scholar]
  49. XiaoJ. NgC.H. ChanK.E. Hepatic, Extra-hepatic outcomes and causes of mortality in NAFLD – An umbrella overview of systematic review of meta-analysis.J. Clin. Exp. Hepatol.202313465666510.1016/j.jceh.2022.11.006 37440949
     [Google Scholar]
  50. LoS.W.K. MuschialliL. FernandezT. SmithC. PeppaD. BurnsF. Investigation into the psychological impact of the COVID-19 pandemic for people living with HIV.Int. J. STD AIDS20233411777784Epub ahead of print10.1177/09564624231179275 37269326
     [Google Scholar]
  51. HongC. QueirozA. HoskinJ. The impact of the COVID‐19 pandemic on mental health, associated factors and coping strategies in people living with HIV: a scoping review.J. Int. AIDS Soc.2023263e2606010.1002/jia2.26060 36912238
     [Google Scholar]
  52. FocàE. FornariC. ArsuffiS. Psychological and emotional impact of COVID-19 pandemic on people living with chronic disease: HIV and cancer.AIDS Behav.20222692920293010.1007/s10461‑022‑03638‑0 35249178
     [Google Scholar]
  53. RidgwayJ.P. SchmittJ. FriedmanE. HIV care continuum and COVID-19 outcomes among people living with HIV during the COVID-19 pandemic, Chicago, IL.AIDS Behav.202024102770277210.1007/s10461‑020‑02905‑2 32382823
     [Google Scholar]
  54. FadulN. ReganN. KaddouraL. SwindellsS. A midwestern academic HIV clinic operation during the COVID-19 pandemic: implementation strategy and preliminary outcomes.J. Int. Assoc. Provid. AIDS Care20212010.1177/23259582211041423 34476989
     [Google Scholar]
  55. Skrzat-KlapaczyńskaA. KowalskaJ.D. AfoninaL. The management of HIV care services in central and eastern europe: Data from the euroguidelines in central and eastern europe network group.Int. J. Environ. Res. Public Health20221913759510.3390/ijerph19137595 35805250
     [Google Scholar]
  56. Nemeth BlažićT. BogdanićN. NolaI.A. Kosanović LičinaM.L. Delaš AždajićM. Digital technology and HIV, HCV and STI voluntary counselling and testing: good practice example from Croatia.Cent. Eur. J. Public Health202230210711010.21101/cejph.a7237 35876599
     [Google Scholar]
/content/journals/chr/10.2174/011570162X310343240812055718
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Impact of the COVID-19 Pandemic on People Newly Diagnosed with HIV and those Already in -care in Türkiye
Current HIV Research 22, 290 (2024); https://doi.org/10.2174/011570162X310343240812055718
/content/journals/chr/10.2174/011570162X310343240812055718
/content/journals/chr/10.2174/011570162X310343240812055718
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  • Article Type:     Research Article
Keyword(s): antiretroviral treatment; COVID-19; healthcare system; HIV care; metabolic changes; people living with HIV
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