Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents) - Volume 14, Issue 2, 2016

Anticoagulation therapy is indicated for management of various clinical conditions to prevent adverse events and introduction of direct oral anticoagulants (DOACs) has ushered in a new era in anticoagulation therapy. Major advantages of DOACS include fewer drug interactions and that they do not need periodic monitoring. Several patients who were not on anticoagulation before due to older age, polypharmacy/drug int Read More

Vitamin D deficiency is common in metropolitan cities of India and worldwide due to faulty life style. The prevalence of vitamin D deficiency has tremendously increased in India despite the fact that it is located between 8.4° and 37.6° north latitude and majority of the Indian population exposed to ample sunlight throughout the year. From published data regarding vitamin D deficiency in India estimated prevalence of vit Read More

Pressure sores are a major complication in the bed-ridden older patient. In this report, we present the case of platelet rich plasma (PRP) application for the treatment of a pressure sore in an 88-year-old female affected by transfusion-dependent chronic inflammatory disease anemia associated with the congenital and inherited condition of thalassemic trait carrier. A weekly application schedule was planned athome, given the pa Read More

Statins are the most widely prescribed drugs to reduce serum low density lipoprotein cholesterol (LDL-C) by inhibiting 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase. LDL-C reduction is associated with a decreased risk of atherosclerotic cardiovascular disease (ASCVD), including cardiovascular disease (CVD) and stroke. Statins reduce LDL-C by 30 to 40%, and the combination with other lipid-lowering agents such Read More

Cancer-associated thrombosis (CAT) accounts for about 20% of all thrombosis worldwide. It is the second leading cause of death in cancer patients. The risk of venous thromboembolism (VTE) is 4 -7 times higher and the risk of recurrent VTE three times higher in the cancer patients, compared to the non-cancer patients. The survival of cancer patients with VTE is lower than that of patients without VTE. In the last two decades, t Read More

Hypovitaminosis D is a worldwide clinical problem, affecting populations in numerous ways. Several factors seem to affect vitamin D metabolism, including the suggestion that therapy with the lipid lowering HMG-CoA inhibitors might modulate vitamin D levels. However, the relationship between statins intake and serum levels of vitamin D is still controversial. The present work aimed to add new insights on the association Read More

Back ground: One of the most prevailing diseases that required effective drug as therapeutic purposes is cardiac related illness includes myocardial infarction Current scenario makes enzyme to raises their sector towards therapeutic as effective active component for such diseases. Objectives: The main aim of the study was to isolate, screen, characterize and produce an extracellular thrombolytic protease from marine actinom Read More

Background: There are data indicating that several azonine-derivatives may exert effects on some biological systems; however, there is very low information on the biological activity induced by these compounds on left ventricular pressure. Objective: The aim of this study was to synthesize and evaluate the biological activity of new triazoninederivative on left ventricular pressure. Material and Methods: The first stage involve Read More

Background: Non-traditional risk factors including low levels of magnesium and high levels of uric acid have been associated with central obesity and cardiovascular disease. Objective: To determine the association between waist circumference (WC) and non-traditional risk factors such as magnesium, phosphorus, and uric acid in indigenous children living at high altitudes. Methods: A total of 354 (166 M) indigenous school c Read More