Current Enzyme Inhibition - Current Issue

Rho kinase (ROCK) enzymes are increasingly recognized for their central role in the pathogenesis of metabolic syndrome (MetS), a cluster of conditions that includes insulin resistance, hypertension, obesity, and dyslipidemia. ROCKs are serine/threonine kinases involved in the regulation of various cellular functions, including smooth muscle contraction, actin cytoskeleton organization, and gene expression. These enzymes ar Read More

BackgroundThe green synthesis of gold nanoparticles (AuNPs) using natural materials has gained significant attention in recent years due to their eco-friendliness and potential applications in various fields.MethodsThe present study aimed at the green synthesis and anti-hyperpigmentation potential of gold nanoparticles (AuNPs) using a methanolic extract of Bauhinia vahlii. Furthermore, the green synthesis of the AuNPs was Read More

BackgroundPyrroles are biologically active scaffolds that can have a number of different effects. They also have unique pharmacophores inside their ring system that make it easier to make molecules that are more active. Significantly, in the past ten years, research has been conducted on the anti-bacterial properties, with a particular emphasis on drug-resistant Gram-positive and Gram-negative pathogens such as mycoba Read More

BackgroundDiabetes prevalence is progressively rising everywhere, particularly in developing countries. Lichens have evolved into a rich source of innovative bioactive chemicals with their anti-oxidant capabilities, widening the scope of well-documented and effective diabetes treatment.ObjectiveThe main objectives of this study were to perform in vitro alpha-amylase, alpha-glucosidase inhibition analysis, and Read More

BackgroundThe present study highlights the comparative therapeutic efficacy of the newly synthesized drug 17-Oximino-5-androsten-3β-yl 4-aminobenzoate (17a-aza steroid) and finasteride for the treatment of experimentally induced prostate carcinogenesis in rats. Considering the inhibitory activity of the oximes to 5α-reductase and the role of the ester group in augmenting the anti-androgenic property, we decided Read More

AimA 2D QSAR study of acyl-coenzyme A (CoA): cholesterol acyltransferase (ACAT) inhibitors revealed that electronic, topological, and steric properties are important structural features required for activity against ACAT.BackgroundIn order to interpret the evidence encrypted by the molecular structure of the compounds, a standard physicochemical descriptors-centered, and Quantitative Structure-Activity Relationshi Read More

AimThe present study aimed to explore the hepatorenal efficacy of ethanolic and hydroalcoholic extract against Gentamicin and Cisplatin-induced toxicity in experimental rats.BackgroundThe current research focuses on the characterization and evaluation of the hepatorenal efficacy of P. granatum extracts on cellular and tissue models, particularly in terms of its restorative actions following cytotoxic damage induced by G Read More