Current Enzyme Inhibition - Current Issue

The aim is to systematize data from literature sources on the study of changes in the activity of HMGR enzymes and lipid metabolism under the influence of cyclic lactones, identify among them new potential inhibitors of HMGR and formulate hypotheses about the details of the mechanism of action of the enzyme in relation to the product - mevalonolactone.

In this modern era, the environment is being contaminated with toxic pollutants as a result of anthropogenic activities. To overcome the harmful effects of pollutants, scientists have developed ideas and technologies. Biotechnology provides a green approach for decontaminating the environment, i.e., bioremediation. Several organisms have been explored for their enzymes. Enzymes belonging to various classes are u Read More

Memory loss or dementia is the key symptom of Alzheimer's disease (AD). In AD, significant interference in a progressive manner is observed in memory, behaviour, and cognitive abilities that affect the daily life of a person. At present, more than 50 million people are affected worldwide with Alzheimer's disease. Urgent attention is needed for the symptomatic regulation and management of this disease. The significant pharm Read More

Background Alzheimer’s disease (AD), a progressive neurodegenerative disease for which there is no effective cure is among the leading causes of death worldwide. Objectives To investigate the potential anti-AD activity of berberine (BBR). Methods In silico assessment included molecular docking and ADMET prediction. BBR’s in vitro inhibitory activity of the target selected from docking results was assessed via colorimetric Read More