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Synthetic Overview of FDA-Approved Dipeptidyl Peptidase-4 Inhibitors (DPP-4I)
Authors: Chandani S. Gori and Yogesh T. NaliaparaAvailable online: 25 February 2025More LessDiabetes mellitus continues to be a major health concern worldwide, contributing significantly to annual mortality and morbidity. Among all types of diabetes mellitus, type 2 diabetes mellitus is a pervasive health condition that affects people worldwide. Recently, various classes of drugs have been proposed for the management of T2DM. Dipeptidyl peptidase-4 inhibitors or gliptins are a class of oral medications for T2DM that t Read More
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Design of Novel Acat Inhibitors as Potent Anti-Hyperlipidemic Agents Using Chemometric Approaches
Authors: Shagufta Khan, Sarvesh Paliwal, Smita Jain and Pragya SharmaAvailable online: 02 December 2024More LessAim A 2D QSAR study of acyl-coenzyme A (CoA): cholesterol acyltransferase (ACAT) inhibitors revealed that electronic, topological, and steric properties are important structural features required for activity against ACAT. Background In order to interpret the evidence encrypted by the molecular structure of the compounds, a standard physicochemical descriptors-centered, and Quantitative Structure-Activity Relationshi Read More
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Exploring the Role of Rho Kinase Enzyme in the Management of Metabolic Syndrome
Authors: Smita Jain and Ajita PaliwalAvailable online: 07 November 2024More LessRho kinase [ROCK] enzymes are increasingly recognized for their central role in the pathogenesis of metabolic syndrome [MetS], a cluster of conditions that includes insulin resistance, hypertension, obesity, and dyslipidemia. ROCKs are serine/threonine kinases involved in the regulation of various cellular functions, including smooth muscle contraction, actin cytoskeleton organization, and gene expression. These enzymes ar Read More
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In vitro and In Silico Molecular Modeling Studies of Newly Synthesized Pyrrole Derivatives for their Antimicrobial and Anticancer Properties
Authors: Saurabh Bhardwaj, Shikha Sharma and Anurag AgrawalAvailable online: 22 October 2024More LessBackground Pyrroles are biologically active scaffolds that can have a number of different effects. They also have unique pharmacophores inside their ring system that make it easier to make molecules that are more active. Significantly, in the past ten years, research has been conducted on the anti-bacterial properties, with a particular emphasis on drug-resistant Gram-positive and Gram-negative pathogens such as mycoba Read More
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Eco-friendly Synthesis of Gold Nanoparticles of Methanolic Extract of Bauhinia vahlii Leaves and Evaluation of Tyrosinase Inhibitory Activity
Authors: Pritipadma Panda, Abhisek Pal, Priyanka Dash, Biswakanth Kar, Goutam Rath and Goutam GhoshAvailable online: 21 October 2024More LessBackground The green synthesis of gold nanoparticles (AuNPs) using natural materials has gained significant attention in recent years due to their eco-friendliness and potential applications in various fields. Methods The present study aimed at the green synthesis and anti-hyperpigmentation potential of gold nanoparticles (AuNPs) using a methanolic extract of Bauhinia vahlii. Furthermore, the green synthesis of the AuNPs was Read More
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