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- Volume 5, Issue 4, 2009
Current Enzyme Inhibition - Volume 5, Issue 4, 2009
Volume 5, Issue 4, 2009
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Cardiac and Renal Nitric Oxide in the Adaptation to Hypovolemic Shock
Authors: Andrea L. Fellet, Alberto Boveris, Cristina T. Arranz and Ana M. BalaszczukEvidence is mounting that NO plays a role in the cardiovascular and renal adaptation to the hemorrhagic shock secondary to major blood loss. Recently, we reported cardiac and renal NO-dependent protective mechanisms activated by the hypovolemic state that include stimulation of NO synthase (NOS) expression and activity. In the heart, an increase in endothelial NOS is an early response to regulate cardiac function aft Read More
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Impaired Expression and Function of Signaling Pathway Enzymes by Anthocyanins: Role on Cancer Prevention and Progression
Anthocyanins (Greek antos, flower and kyanos, blue) are part of a widespread group of plant constituents, collectively known as flavonoids, which occur in the western diet at relatively high concentrations and own a variety of pharmacological properties which make them potential anti-inflammatory and cancer agents. Besides their ability to scavenge reactive oxygen species, anthocyanins exhibit anticancer effects thro Read More
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Breast Cancer Chemoprevention: Current Perspectives
Authors: Takeru Oyama, Yumiko Yasui and Takuji TanakaThe increasing knowledge regarding breast cancer carcinogenesis has provided possible opportunities to prevent breast cancer. This paper reviews the issues related to breast cancer chemoprevention including the identification of high-risk groups, biomarkers and potential chemopreventive agents. Trials with tamoxifen have clearly shown that the risk of developing estrogen receptor (ER)-positive breast cancer can be reduce Read More
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Inhibition of Flaviviridae Replication Complex: Assays to Investigate the Modulating Effect of Potential Compounds
By Andrea BaierApproximately up to 200 million new cases of infections caused by viruses of the Flaviviridae family, like hepatitis C virus (HCV), West-Nile virus (WNV), dengue virus (DENV) and Japanese encephalitis virus (JEV) are registered annually. Up to date, there is no effective antiviral therapy directed against Flaviviridae viruses. For the replication of all viruses the intact function of nonstructural proteins is necessary. The blockade of th Read More
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Controlling the Flow of Energy: Inhibition and Stimulation of the Creatine Transporter
Authors: Maurizio Balestrino, Carlo Gandolfo and Luisa PerassoCreatine in its free and phosphorylated form plays an essential role for maintenance and distribution of ATP levels in tissues with high and fluctuating energy demands such as muscle, brain and heart. Alterations in the creatine concentration in these tissues produce marked functional changes. Creatine concentration is largely determined by a specific creatine transporter, a member of the Na+ dependent transporters Read More
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Inhibitions of Positive-Sense (ss) RNA Viruses RNA-Dependent RNA Polymerases
Authors: Kajohn Boonrod and Gabriele KrczalViral infection in animals and plants is a serious problem worldwide. It causes dramatic losses in health and economy. Many approaches to combat with viral infectious diseases have been intensively investigated. Measures taken against viral infections can either aim for protecting from viral infection or eliminating the viruses after infection. RNA dependent RNA polymerase (RdRp) is a key enzyme for viral replication and foun Read More
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Volumes & issues
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Volume 20 (2024)
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Volume 19 (2023)
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Volume 18 (2022)
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Volume 17 (2021)
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Volume 16 (2020)
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Volume 15 (2019)
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Volume 14 (2018)
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Volume 13 (2017)
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Volume 12 (2016)
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Volume 11 (2015)
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Volume 10 (2014)
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Volume 9 (2013)
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Volume 8 (2012)
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Volume 7 (2011)
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Volume 6 (2010)
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Volume 5 (2009)
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Volume 4 (2008)
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Volume 3 (2007)
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Volume 2 (2006)
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Volume 1 (2005)
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