Current Enzyme Inhibition - Volume 19, Issue 3, 2023

Enzyme inhibitors are an important therapeutic agent in drug discovery, as they can be used to manipulate biochemical pathways to treat a wide range of diseases. Current strategies for enzyme inhibition involve the use of small molecule inhibitors, natural products, or peptide-based inhibitors. These inhibitors can be used to target and modulate the activity of enzymes, which in turn can affect the progression of a par Read More

Cytochrome P450 enzymes are the main drug-metabolizing enzyme, and their activity is influenced by numerous factors, including several plants’ constituents. Herbal products mediated induction or inhibition of cytochrome P450 leads to a change in drug metabolism and consequently, drug bioavailability, safety, therapeutic efficacy, and herb-drug interaction. Since herbal preparations are commonly used either alone or con Read More

Background: Enhanced aldose reductase activity results in increased accumulation of sorbitol. Therefore, inhibition of aldose reductase is an effective strategy to prevent or delay certain diabetic complications. Methods: Various extracts of the leaves of B. orellanawere tested for their inhibitory activity on the aldose reductase. Ethyl acetate extract that showed maximum inhibition was further fractionated and the inhibi Read More

Background: Inhibition of certain specific glutathione S-transferase isozymes is associated with the efficacy of chemotherapy in the treatment of cancer patients. Objective: We aimed to determine whether ascorbic acid, which can be used as a drug and antioxidant food supplement, is a glutathione S-transferase isozyme inhibitor. Methods: For this purpose, glutathione S-transferase was first purified from human erythroc Read More

Background: The growing occurrence of complications associated with diabetes calls for the unending exploration of natural products for more efficient therapeutic substances. The polyol pathway is a foundational scheme involved in the development of diabetic complications. Retarding the activities of enzymes in the polyol pathway is, therefore, a potent method of managing these complications. Objective: This work assess Read More

Background: Oxidative stress is implicated in many neurodegenerative disorders, such as Alzheimer’s disease. As an alternative, Punica granatumpeels are widely used in the treatment of several ailments. To date, this is the first study on the anti-acetyl/butyrylcholinesterase effects of diethyl ether extract from Algerian pomegranate peels. Objective: This research aimed to evaluate the content of total phenolics, flavon Read More

Background: The primary goal of researchers interested in the field of oncology continues to be the development of a new anti-cancer medicine with minimal side effects. Due to their minimal toxicity and impressive performance, natural source-mediated anti-cancer treatments are attracting a lot of attention. Objective: The purpose of the current work was to extract and purify resveratrol from local Leguminosae, such as pea Read More