Current Enzyme Inhibition - Volume 19, Issue 1, 2023

Background: Benzofurans, interesting heterocyclic compounds, are available abundantly in nature and show a wider range of pharmacological activities. Moreover, in recent years this moiety has been found to have strong antituberculosis potential. Considering the importance of this moiety in the field of medicinal chemistry, we have synthesized a few benzofuran derivatives. Methods: These derivatives were also characteriz Read More

Background: α-Amylase inhibitors are considered an important therapeutic target to control type 2 diabetes mellitus, reducing postprandial hyperglycemia. Medicinal plants are an important source with inhibitory activities of this enzyme but are little studied. Objective: The present study explored the α-amylase inhibition with extracts of 11 medicinal plants available in Saltillo, Mexico; the kinetic mechanism of inhibition of Read More

Backgound: Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease, clinically characterized by memory and cognitive dysfunction. AD affects about 35 million people worldwide today and is estimated to nearly double every 20 years. Cnidoscolus aconitifolius (Miller) I.M. Johnston has been reported in Nigerian ethnomedicine as a memory enhancer. There is a lack of scientific evidence to justify the cla Read More

Background: Aromatase is a catalytic enzyme involved in the biosynthesis of estrogen from androgen. It catalyzes the last rate-limiting/crucial critical step in estrogen biosynthesis. Following the success of the aromatase inhibitor, researchers are working on developing a small physiologically active molecule with fewer side effects and improved tolerance. Objectives: Inhibition of the aromatase enzyme, which pl Read More

Background: Gestational diabetes mellitus (GDM) is one of the prediabetes conditions in which high blood sugar levels and body weight increase during pregnancy. The underlying molecular and biochemical mechanisms of GDM have been poorly defined. Introduction: Aromatase enzyme activity is responsible for the conversion of androgens to estrogens and has a share in the regulation of body fat distribution and liver re Read More

Background: Breast cancer is currently the most diagnosed cancer worldwide. Neoplastic cells and components of the tumor microenvironment trigger enzymes and receptors to facilitate cancer advancement. Syringin, a natural phenylpropanoid glycoside, has been reported to possess anti-cancer activity and affinity with numerous druggable targets of breast carcinoma. Objectives: This work aims to evaluate the effects of s Read More

Background: Acute poisoning by Ethoprphos, an organophosphorus pesticide, leads to a veritable cholinergic syndrome whose diagnosis is based on the determination of cholinesterase activity. The treatment relies on the administration of atropine and pralidoxime to regenerate cholinesterases before their ageing. Case: We report a case of a two-year-old child, hospitalized for ethoprophos poisoning, with seizures associated with Read More