Current Enzyme Inhibition - Volume 19, Issue 2, 2023

Background: Cancer is the abnormal growth of cells in the body due to an imbalance in the normal apoptotic pathways. The abnormality in the cancer cells makes them malignant. Various types of treatment, including chemotherapy, radiation therapy, targeted therapy, and immunotherapy (IMT), are used for cancer. Mesenchymal-epithelial transition factor (c-Met) belongs to the tyrosine kinase receptor family and is overex Read More

Introduction: Overexpression of tyrosinase in humans causes an increase in melanin production in the skin, which can result in hyperpigmentation consequences such as freckles, melasma, age spots, and melanoma. Free radicals also play a significant role in the increase of the biosynthesis of melanin. Tyrosinase inhibitors capable of inhibiting the biosynthesis of melanin are currently used in various hyperpigmentation and cos Read More

Introduction: Oxidative stress plays a critical role in the pathological process of Alzheimer’s disease (AD). There is a growing interest in natural anti-oxidants and cholinesterase inhibitors from medicinal plants that may aid in the prevention of oxidative injury and treatment of AD. Considering this, Athamanta sicula L. is found to be an important medicinal plant. Aims: The aim of the current study was to investigate the total phe Read More

Introduction: Oxidative stress plays a major role in developing diabetes complications; therefore, it is possible to use natural antioxidants as therapeutic agents for diabetes. Aims: This study aimed to find an important source of phenolics from Athamanta sicula L. (A. sicula) and confirm that this plant could be a significant source of medically important natural compounds by confirming its antioxidant, α-amylase and α-gl Read More

Background: Diabetes type II is one of the most serious metabolic diseases in the world attracting the attention of many researchers who predict that diabetes will be one of the top major causes of disability or death in the coming few decades. To tackle this disease several classes of synthetic molecules were developed to target certain enzymes that are involved in sugar metabolism. Herbal extracts targeting diabetes have wit Read More

Background: Emerging data indicate that BCHE, a gene encoding the enzyme butyrylcholinesterase, is a negative prognostic marker in MYCN-amplified neuroblastoma. Levels of butyrylcholinesterase in children newly diagnosed with neuroblastoma are proportional to MYCN amplification and the response to therapy. To better understand the functions of butyrylcholinesterase in neuroblastoma, we examine interactions of t Read More

Background: Around ten novel pyrazoline and pyrazolidine derivatives were designed and synthesized by the condensation of piperine, hydrazine hydrate, phenylhydrazine, aromatic carboxylic acid, and ethanol. Methods: The synthesized compounds (2, 3, 4a-d, and 5a-d) were characterized by FTIR, 1HNMR, mass spectral, and elemental analysis. Pharmacokinetic, physicochemical, drug-likeness, and medicinal chemistry frien Read More

Background: Calamintha nepeta is a plant from the Lamiaceae family that is known for its traditional use to treat diabetes among Algerian populations. However, till now, there has been no research work to confirm this activity. Objectives: This work aimed to evaluate the amylase inhibitory activity of essential oils and phenolic compounds from both methanolic and aqueous extracts of Algerian Calamintha nepeta ( Read More

Background: Rhanterium adpressum is an endemic and desert plant found in Algerian Sahara, it is used by the local population in cheese production and folk medicine as an antidiuretic and antimicrobial. Objective: This study aimed to analyse the phytochemical composition of Rhanterium adpressum extracts by GC-MS and assess their inhibitory potential on α-amylase and α-glucosidase enzymes linked to diabe Read More

Background: Clinical studies have already revealed the ubiquitous neuroprotective role of curcumin in neuronal deterioration, but it cannot be used alone due to its truncated bioavailability. Currently, many such approaches are functional, which overcome this issue either by increasing the solubility or absorption. These approaches carry a costlier treatment. One more tactic is present but less focused i.e., by limiting the inte Read More