Current Enzyme Inhibition - Volume 17, Issue 1, 2021

Background: Bacterial manganese superoxide dismutase (MnSOD) occurs as a dimer, which is responsible for its activity and stability. Therefore, increasing the dimeric strength would increase the stability of the enzyme while maintaining its activity. Objective: An N73F substitution was introduced to strengthen interactions between the monomers at the dimer interface. This substitution would introduce a π-stacking inter Read More

Background: For the past 70 years, the focus of research is on the search for poisons and toxins found in venomous and poisonous organisms, purely directed towards the pharmacological properties of the toxins. In the research of finding novel compounds in pharmaceutical research, the identified source was the piscine venom. Objective: The Scorpaenidae family was considered the most venomous of all. The toxins isolat Read More

Introduction: 5α-reductase inhibitors have been proven useful for the treatment of prostate diseases, which can be due to the unregulated activity of 5α-reductase enzyme. This study was focused on determining the activity of four different derivatives of 17β-phenyl carbamoyl-androst-4-en-3-one 1–4 as inhibitors of 5α-reductase (5RD5A), to improve the effects of current drugs. Methods: In vitro effect of compounds 1-4 on the Read More

Background: The Spectrophotometric method is one of the most suitable analytical techniques for testing the activity of enzymes under the influence of various factors. Methods: The effect of H1-antihistamines of loratadine and calcium ions on enzyme catalase under in vitro conditions was investigated in this paper. Results and Discussion: It has been shown that loratadine is a partial inhibitor of catalase, but this effect is Read More

Introduction: Prostate cancer (Pc) is the most frequent neoplasia in men and the second cause of death in Brazil. Objective: To analyze the interactions and biologicals responses of Pc oxidative stress and prostatespecific antigen (PSA), E-cadherin and MMP-13. Demonstrate whether the increase of the amount of the form of E-cadherin found in the plasma of Pc patients, correlates with decrease of the PSA. Methods: Sam Read More

Background: Phyllanthus fraternus Webster Linn (family, Euphorbiaceae) is used as a traditional medication for the treatment of various disorders and has therapeutic implications. Objective: This study intends to investigate the anxiolytic potential of Phyllanthus fraternus standardized extract and prediction of the probable role of its marker phytoconstituents. Methods: We tested the standardized hydro-ethanolic extract of Phyl Read More

Background: Curcumin, a providential spice, has its role in protecting the brain from neurodegeneration. Despite its ubiquitous role, it is not exploited alone due to its hampered bioavailability. By restraining the intestinal and liver enzymatic metabolism, one can boost the bioavailability of curcumin and promotes reabsorption of the curcumin. Diclofenac inhibits uridine 5'-diphosphoglucuronosyltransferase enzymes specific Read More

Background: Lymphatic filariasis, regularly known as elephantiasis, is a dismissed tropical malady. A filarial parasite causes the disease when it is transmitted to humans through mosquitoes. The World Health Organization distinguished that this is one of the subsequent driving reasons for lasting and long haul inability. Inaccessibility of immunization and medication opposition of a large portion of the ebb and flow hostile to f Read More

Background: Oxidative stress is caused due to the overproduction of the reactive oxygen species (ROS) and the disturbance developed in the antioxidant potential of biochemical processes. ROS mostly form in the brain due to the high consumption of oxygen and the insufficiency of endogenous antioxidant resistance mechanisms. Cytochrome P450 2E1 has an excessive percentage of NADPH oxidase activity, which c Read More