Current Enzyme Inhibition - Volume 14, Issue 3, 2018

Background: With the increase of resistance rates among many pathogenic bacterial species, this led to a huge public health problem; the ongoing need for the development of new antibiotics that target new pathways is obvious. As such, the MetAP is an attractive target for the development of new antimicrobials, because it is involved in the protein processing in bacteria. Objective: To screen the potential MetAP of Mycobacteriu Read More

Background: Some of chemical syntheses are attractive because of their pharmacological application in the drug industry. Materials and Methods: In this study, water soluble peripherally and non-peripherally tetra substituted novel zinc (II) phthalocyanines, which were tagged as ZnPC, investigated against the inhibition of urease and hyaluronidase (HYA). In addition to enzyme inhibitory activities, antioxidant activity of sy Read More

Background: Diabetes mellitus is the most common disease in the world. One of the approaches therapy used to treat diabetes is inhibition of α -glucosidase activity by natural inhibitors from the plant. Objective: Our work comes to highlight, in vitro, the effect of phenolic extracts of some Algerian Saharan Atlas medicinal plants on the activity of α-glucosidase. Methods: The ethyl acetate extracts were prepared from hydro Read More

Background: The renin-angiotensin system (RAS) is a critical contributing factor to obesity and related diseases. Several studies have shown the relationship of obesity with cyclooxygenase-2. Objectives: Based on these facts, we aimed to investigate the celecoxib oral administration (a selective anti-inflammatory inhibitor of cyclooxygenase-2 (ICOX-2)) effects, in mice fed a high-fat diet by assessing the renin-angiotensin Read More

Introduction: Sarcandra glabra has been used in traditional medicine to improve mental efficiency and to reduce stress. Volatile oil, phenolic acids, polysaccharide, terpenoids, saponins and flavonoids are bioactive compounds present in Sarcandra glabra. Materials and Methods: In this paper, we evaluated the antioxidant capacity and acetylcholinesterase (AChE) inhibitory activity in vitro of different fractions of Sarcandra glabr Read More

Background: Cleome arabica belongs to the family of Capparaceae. It has attracted a great deal of attention in recent years for its pharmaceutical potentials due to its antioxidant, antihypercholisterolemic, anti-cancer and chemoprotective activities for the treatment of a number of diseases. Objective: The main study was to evaluate the α-amylase inhibitory and antioxidant activities of extracts from Cleome arabica collected Read More

Introduction: This study investigated the in vitro inhibition properties of newly synthesized coumarin derivates (C1-C5) against human carbonic anhdyrase I (hCA-I) and jack bean urease. Activities were expressed as IC50 (mg/mL), the concentration reducing 50% of the enzymes. The IC50 values for hCA-I ranged 5.20 μM from 12.10 μM, with compound C3 exhibiting the highest activity. The inhibition values for urease range Read More