Current Enzyme Inhibition - Volume 13, Issue 3, 2017

Background: Inhibition of Dipeptidyl peptidase IV (DPP IV) enzyme is an attractive and appropriate target for the treatment of type 2 diabetes. In order to discover for potent DPP IV inhibitors a chemoinformatics studies were performed on fifty nine trifluorophenyl β-aminoamide derivatives using Sybyl X 2.1.1. Methods: The comparative molecular field analysis (CoMFA), comparative molecular similarity index analysis (CoMSI Read More

Background: The glyoxylate shunt of fatty acid metabolism is critical to the survival of Mycobacterium tuberculosis (Mtb) during the dormant stage. The two enzymes of glyoxylate shunt pathway, isocitrate lyase (ICL) and malate synthase (MS), have been identified to be involved in Mtb persistence and become the attractive targets to intervene with the pathway. Methods: In order to search novel MS inhibitors, molecular Read More

Background: The glycolytic pathway plays an important role in tumor cells. Triosephosphate isomerase (TIM) catalyzes the reversible isomerization of D-glyceraldehyde-3-phosphate (GAP) to dihydroxyacetone phosphate (DHAP) in the glycolysis. Proteomics of a human prostate adenocarcinoma cell line revealed the presence of the G233D TIM variant, a new allelic type whose biochemical properties have not been reported [1]. O Read More

Background: Type 2 diabetes (T2D) is a swiftly growing disease which affects human health seriously around the world. So far, nine DPP-4 inhibitors have been launched on the markets for patients with T2D. The aminomethyl biaryl derivatives, with a novel structure scaffold, have been proved as potential DPP-4 inhibitors. Our team focused on the modification of aminomethyl biaryl derivatives through the pharmacophore model. Read More

Background: Biosurfactants are natural extracellular products that are produced by several microorganisms. These compounds are highly developed during recent years for industrial, medical, and environmental applications. Although, the majority of microbial biosurfactants were originated from bacterial species, some studies have shown that Rhodotorula muciliginosa and Candida rugosa are fungal sources for bi Read More

Introduction: Broad spectrums of antibiotics are widely used in the treatment of bacterial infections, particularly causing Staphylococcus aureus. These drugs have high acute renal injury (AKI) potency due to an increase in nitric oxide level. In this study, potency of nitric oxide synthase inhibition of some antibiotics was investigated according to vancomycin which was used as a reference antibiotic in renal injury. Methods Read More

Background: Pyrazolo[3,4-d]pyrimidine compounds are reported to exhibit various pharmacological activities including antitubercular. The mycobacterium trifunctional enzyme_mtTFE is a vital constituent of β-oxidation pathway for lipid metabolism of tubercle bacillus. Method: In this article, the quantum polarized ligand docking of some pyrazolo[3,4-d]pyrimidine molecules have been conducted within the active site o Read More

Abstract: Background: Present world is badly affected by AIDS. The chief causative agent for AIDS is HIV. The essential milk proteins; bovine lactoferrin (bLF) and human lactoferrin (hLF) are known to obstruct the interaction between HIV gp120 and DC-SIGN protein after sexual transmission. Earlier several research studies have been performed to document the active participation of gp120 protein and lactoferri Read More

Background: Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) is one of the proangiogenic factors that promotes endothelial cell proliferation, migration, differentiation, tube formation and thus helps in the angiogenesis and progression of cancers. Considering the VEGFR-2 as a prominent target for angiogenesis inhibition, the present study was focused to a potent phytochemical shikonin as potential lead mole Read More