Current Enzyme Inhibition - Volume 11, Issue 1, 2015

The central nervous system (CNS) is composed of numerous neural cells such as neurons and glias that have wide cell surface and numerous processes covered with plasma membranes. As the plasma membrane is enriched in cholesterol, the CNS composed of numerous neural cells with wide plasma membrane is a cholesterol- rich organ. Because inhibition of cholesterol supply induces cell death into neurons, the CNS is Read More

Accurate measurement of the quantitative aspects of enzyme-catalysed reactions is critical for a deeper understanding of their mechanisms, for their exploitation in biotechnology and for targeting enzymes by drug-like molecules. It is important to move beyond basic enzyme kinetics as encapsulated in the Michaelis-Menten equation. The type and magnitude of inhibition should be determined. Since the majority of enzy Read More

The new 3,4-dimethoxybenzoate complex of Cu(II) with nicotinamide was synthesized and characterized by elemental analysis, FT-IR spectroscopic study, UV-Vis spectrophotometry and mass spectrometry. The thermal behavior of the complex was studied by simultaneous TG, DTG and DTA methods in static air atmosphere. The infrared spectral characteristics of the complex is also discussed. In this complex, all ligands are c Read More

Cimetidine is a histamine H2-receptor antagonist which is used in gastrointestinal diseases. Although this drug is designed for H2 receptor, it can also attach to other enzymes. Alkaline phosphatase (ALP) is an important enzyme used for obtaining inorganic phosphate from organic phosphorylated substrate in microorganisms. In this study, effect of cimetidine on the ALP of Escherichia coli and Saccharomyces cerevi Read More

Nearly all antibiotics are ineffective to the antibiotic-resistant bacteria New Delhi metallo-beta -lactamase-1(NDM-1), one of the most important reasons is that antibiotics can be hydrolyzed by NDM-1 in these bacteria. Up to date, Many compounds, including captopril, are found to possess NDM-1 inhibition activity. Herein we report that some cysteine derivatives or homocysteine derivatives can inhibit the NDM-1 protein, an Read More

The present study was carried out to screen microalgae for anticholinesterases. Acetylcholinesterase and butyrylcholinesterase were collected from human RBC ghost and sera respectively. Different algal species were collected from different study area and they were screened, isolated and cultivated with essential media. Crude extracts of the selected microalgae were fractionated by sequential extraction using various orga Read More

The steroid derivative EM-1913 is a non-estrogenic inhibitor of steroid sulfatase (STS), an enzyme involved in the biosynthesis of estrogens and androgens. As an approach to treat estrogen-dependent diseases such as breast cancer, we want to test EM-1913 in an estrogen-dependent breast cancer tumor model in vivo. Ovariectomized nude mice were inoculated with estrogen-sensitive human breast cancer MCF-7 cells and st Read More