Current Drug Therapy - Volume 8, Issue 2, 2013

Objective: To assess the efficacy of inhaled, repeat doses (28 days) of the glucocorticoid agonist GW870086. Methods: This was a randomised, placebo-controlled, parallel group study in subjects with persistent asthma (n=135) who received GW870086 (2, 3, or 4 mg, once-daily) or placebo. Results: Improvements in forced expiratory volume in one second (FEV1) were seen following all three doses of GW870086 relative to pl Read More

Aim and Methods: We conducted two studies in healthy male subjects to assess the effect on serum cortisol levels of the novel inhaled corticosteroid GW870086, dosed at 6 mg, 12 mg and 15 mg/day (dry powder inhaler; NCT00549497) for 3 days and 5 mg and 8.75 mg/day (nebules; NCT01160003) for 14 days. Results: In the 3-Day Study, the greatest suppression of serum cortisol weighted mean (0-24 hour) Read More

Tuberculosis is a neglected disease caused by Mycobacterium tuberculosis. Some evidence suggests its existence since thousands of years and today it still represents a public health problem. Current treatment presents serious problems such as adverse effects, high cost, long term, besides the emergence of resistant strains. Therefore the search for new antimicrobials is still in need. In this work we reviewed tuberculosis tre Read More

Inflammatory bowel disease (IBD), commonly known as Crohn’s disease and ulcerative colitis, is a frequently occurring disease in Gastroenterology, which is characterized by a chronic intestinal inflammatory ailment. The therapy of IBD is dominated by the administration of anti-inflammatory and immune-modulating drugs, which suppress the intestinal inflammation and thus improve disease-related symptoms. The enhanced i Read More

Delivery of hydrophobic drugs via buccal route is a challenging approach. Isradipine (IDP) is a highly hydrophobic drug and is practically insoluble in water. Though the log p value of Isradipine permits the drug to pass through buccal membrane, the amount of drug delivered is low. The aim of present investigation is to develop buccal tablets containing Isradipine complexed with a β-cyclodextrin. Differential scanning calorimetr Read More

We summarize the alterations of classical neurotransmitters and neuropeptides, including their specific subreceptors, involved in schizophrenia. The essential susceptibility genes in schizophrenia and their coherence to neurotransmitter alterations are highlighted. In this sense, dopamine and serotonin hyperactivity in the mesolimbic system and the hippocampus is due to a reduced presynaptic inhibition carried out by GABA a Read More