Current Drug Therapy - Volume 13, Issue 1, 2018

Brain targeting has always been challenging due to the presence of various physiological barriers resulting in low bioavailability via the oral and parenteral route. Altering the integrity of these barriers so as to permit the drugs to enter into the brain could severely damage the Central Nervous System by also allowing the entrance of toxic substances, bacteria and viruses into the brain. This problem can be tackled by d Read More

Background: Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and causing significant disability in many patients. Neuro-Myelitis Optica Spectrum Disorder (NMOSD) is a rare disorder that was considered a subtype of MS but is now recognized as a distinct demyelinating disorder that affects Read More

Objective: This research work aimed to develop bucco-adhesive patches, which release curcumin in the oral cavity for an extended duration thereby assisting in the cure of oral thrush (candidiasis). Fluconazole containing patches were also developed in order to compare the effectiveness of curcumin patches against Candida albicans. Method: After suitable preformulation studies, five formulations of curcumin were prepar Read More

Background: Tuberculosis is a threat to humankind due to the development of resistance against the existing drugs, so new drugs are an absolute necessity. Neuroleptic phenothiazines were reported for antitubercular activity, but the associated antipsychotic effect restricted their antitubercular use. Objective: Novel mycobacterial ATP synthase inhibitors having structural similarity with phenothiazines were designe Read More

Background: Monensin is a broad spectrum polyether antibiotic produced by Streptomyces cinnamonensis. It is widely used as veterinary medicine in the treatment of coccidiosis. Objective: The goal of this study was to assess the antimalarial efficacy of monensin in liposomal form in combination with potent antimalarial drugs like chloroquine, piperaquine, or FR900098 in free form under in vitro and in vivo condition. Read More

Background: Hydrochlorothiazide (HCTZ) is a thiazide diuretic and also possesses an anti-hypertensive effect. It is BCS class IV drug with very poor aqueous solubility and permeability. Objective: The objective of the present work was to enhance the solubility and permeability of hydrochlorothiazide via self microemulsifying drug delivery system (SMEDDS) and to optimize gastro-retentive floating delivery for Solid- Read More

Background: Colorectal cancer is a major public health problem in the developed world. Capsaicin, a spicy component of hot pepper that preferentially induces certain cancer cells to undergo apoptosis including colon cancer cells. Objective: The aim of the present investigation was to entrap nanoemulsome containing capsaicin in gellan gum hydrogel beads and further coated with Eudragit S100 for site specific deliver Read More