Current Drug Therapy - Volume 12, Issue 2, 2017

Background: Ezetimibe is an inhibitor of the intestinal absorption of cholesterol. There are different cholesterol transporters in small intestine and one of the most important is Niemann-Pick C1L1 protein (NPC1L1), who is the therapeutic target of ezetimibe. When we talk about cholesterol gallstones disease, we deal with a public health problem, whose pharmacological treatment is limited. Ursodeoxycholic acid is used to di Read More

Background: Swine influenza is a seasonal health threat due to global outbreak of H1N1 pandemic in 2009 leading to death of millions of people because of antigenic drift of the dangerous influenza A viral strains. Scarcity of specific chemotherapeutics emphasizes the priority of drug design and discovery of new anti-influenza leads having less toxicity and resistant to the dynamic viral strains. Objective: The present review is Read More

Background: The resistant to current therapy against tuberculosis is tremendously increasing, novel potential anti-tubercular compounds should be developed at the urge. The presently reported analogues act by binding to the kat-G gene present in Mycobacterium tuberculosis which converts them into active form, thereby inhibiting inhA mediated mycolic acid synthesis. Objective: To establish structure activity relationship, ide Read More

Objective: The aim of present study is to develop and explore efficiency of 5.0G EDA PAMAM dendrimers as long-duration drug release carriers for the treatment of tuberculosis. Method: Rifampicin (RIF) was selected as a major drug for incorporation into PAMAM dendrimers based on its anti-tubercular activity and hydrophobic nature. Further polyethylene glycol (PEGylated) PAMAM dendrimers were evaluated for their hemoly Read More

Background: Ceftriaxone belongs to the third-generation β-lactam antibiotics and it is useful for the treatment of a number of infectious diseases caused by both aerobic and anaerobic Gram-positive and Gram-negative bacteria. Phenylalanine is an essential aromatic amino acid of human being, from which dopamine and norepinephrine neurotransmitters are being synthesized. In the present study, we examined their com Read More

Background: The damage of synapses and neurons leads to the cognitive impairment and this is the root cause of progression of Alzheimer's disease. The nematode Caenorhabditis elegans is widely used as an in vivo model to study the synaptic transmission because of the relatively modest worm nervous system, which is like mammals. Objective: The aim of this work is to assess the effectiveness of resveratrol-loade Read More

Background: The anti-anginal agent ivabradine hydrochloride acts by selective and specific inhibition of the cardiac pacemaker current. The oral bioavailability of ivabradine is approximately 40% because of first-pass effect in liver and intestines. Objective: The present study targets QbD abetted formulation and in vivo evaluation of transdermal patch to avoid limitations allied with oral administration. Method: Transdermal Read More