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image of A Comprehensive Review of the Phytochemicals, Nutritional Values, and Therapeutic Applications of Albizia lebbeck

Abstract

Plants have been a source of medicinal phytoconstituents since ancient times and the knowledge has passed through generations of medicinal use. Medicinal plants contain not one but an amalgamation of various Phyto-derived moieties that are therapeutically active. One such plant that has come into light for its various employabilities is Albizia lebbeck, more commonly known as Siris. It is mainly grown in the Indian subcontinent and nearby countries such as Myanmar, Sri Lanka, and eastern Pakistan. Various studies investigating the dynamics of siris have reported therapeutic actions such as anti-inflammatory, anti-cancer, antioxidant, neuroprotective, anti-diarrheal activity, and anti-diabetic activity. These activities can be attributed to various Phytochemicals such as alkaloids, flavonoids, terpenes, and saponins. However, apart from these well-reported actions, multiple other therapeutic uses are currently under investigation such as anti-hyperlipidaemic. In this review, we presented its different types of therapeutic uses, its various Phyto constituents, and its botanical classification.

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2024-12-02
2024-12-26

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References

  1. Jyothi M.V. Vl A.B. Wagh V.D. Rasheed A. Dayaramani R. Panigrahy U.P. Wal P. Gunjal S.D. Herbal interactions with cardiac medications: A comprehensive review of potential interactions between herbal drugs and commonly prescribed cardiac medications. Curr. Drug Saf. 2024 19 10.2174/0115748863289321240424063819 38726779
    [Google Scholar]
  2. Han Y. Sun H. Zhang A. Yan G. Wang X. Chinmedomics, a new strategy for evaluating the therapeutic efficacy of herbal medicines. Pharmacol. Ther. 2020 216 107680 10.1016/j.pharmthera.2020.107680 32956722
    [Google Scholar]
  3. Waseem A Jamal A Ahmad W Fazil M. Siras (Albizia lebbeck (L.) Benth.) and its medicinal uses in Unani medicine-a review. Cell. Med 2020 10 2
    [Google Scholar]
  4. Balkrishna A. Sakshi Chauhan M. Dabas A. Arya V. A Comprehensive Insight into the phytochemical, pharmacological potential, and traditional medicinal uses of Albizia lebbeck (L.) Benth. Evid. Based Complement. Alternat. Med. 2022 2022 1 19 10.1155/2022/5359669 35497931
    [Google Scholar]
  5. Avoseh O.N. Mtunzi F.M. Ogunwande I.A. Ascrizzi R. Guido F. Albizia lebbeck and Albizia zygia volatile oils exhibit anti-nociceptive and anti-inflammatory properties in pain models. J. Ethnopharmacol. 2021 268 113676 10.1016/j.jep.2020.113676 33301915
    [Google Scholar]
  6. Elshiekh YH Alagbash RE Ali RA Saad FO Musharaf M Musharaf M. Phytochemical constituents, antibacterial screening and antioxidant activity of Albizia lebbeck (L.) Benth (Seed). WJARR 2020 7 1 35 40
    [Google Scholar]
  7. Bobby MN Rani MH Wesely EG Pandian MR Comparative morpho-anatomical studies of Albizia lebbeck (L.) Benth and in vitro micro propagated plantlets. J. Med. Pharm. Allied Sci. 2024 13 6401 6407
    [Google Scholar]
  8. Latif A. Malik S.A. Saeed S. Zaka S.M. Sarwar Z.M. Ali M. Azhar M.F. Javaid M. Ishtiaq M. Naeem-Ullah U. Naoreen M. Khan K.A. Ghramh H.A. Shahzad M.A. Pollination biology of Albizia lebbeck (L.) Benth. (Fabaceae: Mimosoideae) with reference to insect floral visitors. Saudi J. Biol. Sci. 2019 26 7 1548 1552 10.1016/j.sjbs.2018.12.005 31762624
    [Google Scholar]
  9. Fakoya A. Adeleke B.S. Adegbehingbe K.T. Adejoro D.O. Jemilaiye T.A. Effect of fermentation on the nutrient and antinutrient contents of lebbeck (Albizia lebbeck) seeds. JETEAS 2018 9 5 227 233
    [Google Scholar]
  10. Ba Tuyen P. Huyen T.T. Hang D.T.T. Thi Van Anh P. A novel herbal medicine for dyslipidemia: Assessments in experimental models. Evid. Based Complement. Alternat. Med. 2021 2021 1 5 10.1155/2021/5529744 33976702
    [Google Scholar]
  11. Guo W.X. Lu X.G. Zhan L.B. Song Y. Chinese herbal medicine therapy for hyperlipidemic acute pancreatitis: A systematic review and meta-analysis of randomized controlled trials. Eur. Rev. Med. Pharmacol. Sci. 2023 27 6 2256 2276 37013744
    [Google Scholar]
  12. Obika O.I. Obika I.E. Pharmacognostic characters of Albizia lebbeck (L.) Benth. leaves: macroscopy, microscopy, and phytochemical analysis. Life Res. 2023 6 3 12 10.53388/LR20230012
    [Google Scholar]
  13. Sharma T. Rani C. Kumar D. Kumar H. Deep A. Phytochemical screening and traditional medicinal potential of Albizia Lebbeck (L.) Benth: An update. TMR Mod. Herb. Med. 2022 5 4 23 10.53388/MHM2022B0826001
    [Google Scholar]
  14. Missanjo E Maya C Kapira D Banda H Kamanga-Thole G Effect of seed size and pretreatment methods on germination of Albizia lebbeck International Scholarly Research Notices Wiley 2013
    [Google Scholar]
  15. El Khodary Y.A. Ayoub I.M. El-Ahmady S.H. Ibrahim N. Molecular and phytochemical variability among genus Albizia: A phylogenetic prospect for future breeding. Mol. Biol. Rep. 2021 48 3 2619 2628 10.1007/s11033‑021‑06316‑x 33792827
    [Google Scholar]
  16. Singab AN Bahgat D Al-Sayed E Eldahshan O Saponins from genus Albizia: Phytochemical and biological review. Med. Aroma. Plants. S 2015 3 001
    [Google Scholar]
  17. Abd El-Ghany A.E. Dora G. Abdallah R.H. Hassan W. El-Salam E.A. Phytochemical and biological study of Albizia lebbeck stem bark. J. Chem. Pharm. Res. 2015 7 29 43
    [Google Scholar]
  18. Chulet R. Pradhan P. Sarwan S.K. Mahesh J.K. Phytochemical screening and antimicrobial activity of Albizzia lebbeck. J. Chem. Pharm. Res. 2010 2 5 476 484
    [Google Scholar]
  19. Padamanabhan V. Ganapathy M. Evanjelene V.K. Preliminary phytochemical and anti-bacterial studies on flowers and pods of Albizia lebbeck (Benth). Int. J. Emerg. Technol. Adv. Eng. 2013 3 9 541 544
    [Google Scholar]
  20. Chitra P. Balasubramanian A. A study on chemical composition and nutritive value of albizia tree leaves as a livestock feed. Int. J. Sci. Environ. Technol. 2016 5 6 4638 4642
    [Google Scholar]
  21. Saha M. Rahman S.M. Rahman M.A. Analysis of fatty acids of the seeds and leaf of the Albizia lebbeck fruits. Int. J. Adv. Pharm. 2016 5 2 105 108
    [Google Scholar]
  22. Okoruwa M.I. Bamigboye F.O. Ikhimioya I. Dietary Albizia lebbeck leaf and millet sievate effects on digestibility, rumen environment and haematological indices of goats. Livest. Res. Rural Dev. 2022 35 9 79
    [Google Scholar]
  23. Praengam K. Muangnoi C. Charoenkiatkul S. Thiyajai P. Tuntipopipat S. Antioxidant and anti-inflammatory activity of aqueous fraction from Albizia lebbeck leaves. Int. Food Res. J. 2017 24 3
    [Google Scholar]
  24. Ekun O. Antioxidant Properties of Albizia lebbeck Seed Protein Hydrolysates. Int. j. appl. biol. 2022 6 2 101 114 10.20956/ijab.v6i2.21015
    [Google Scholar]
  25. Meshram G.G. Kumar A. Rizvi W. Tripathi C.D. Khan R.A. Evaluation of the anti-inflammatory activity of the aqueous and ethanolic extracts of the leaves of Albizzia lebbeck in rats. J. Tradit. Complement. Med. 2016 6 2 172 175 10.1016/j.jtcme.2014.11.038 27114941
    [Google Scholar]
  26. Wudil KN Analysis of some phytochemicals and minerals found in aqueous stem bark extract of Albizia Lebbeck.
    [Google Scholar]
  27. He Y. Wang Q. Ye Y. Liu Z. Sun H. The ethnopharmacology, phytochemistry, pharmacology and toxicology of genus Albizia: A review. J. Ethnopharmacol. 2020 257 112677 10.1016/j.jep.2020.112677 32278761
    [Google Scholar]
  28. Saleem U. Raza Z. Anwar F. Chaudary Z. Ahmad B. Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson’s disease. BMC Complement. Altern. Med. 2019 19 1 352 10.1186/s12906‑019‑2772‑5 31805998
    [Google Scholar]
  29. Hammad H. Lambrecht B.N. The basic immunology of asthma. Cell 2021 184 6 1469 1485 10.1016/j.cell.2021.02.016 33711259
    [Google Scholar]
  30. Chaudhary S. Gulati K. Rai N. Ray A. Anti-inflammatory and immunomodulatory effects of Albizia lebbeck in experimental model of bronchial asthma. Indian J. Chest Dis. Allied Sci. 2022 60 3 147 152 10.5005/ijcdas‑60‑3‑147
    [Google Scholar]
  31. Kaushik R. Subhose V. Londhe D. Prakash O. Antiasthmatic potential of shirisha (Albizia lebbeck (L.) benth). J. Drug Res. Ayurvedic. Sci. 2017 2 4 295 300 10.5005/jp‑journals‑10059‑0026
    [Google Scholar]
  32. Suman A. Prasad M. Antiinflammatory activity of Albizia lebbeck (L.) BENTH. J. Drug Deliv. Ther. 2019 9 4-s 1123 1128
    [Google Scholar]
  33. Cui W. Aouidate A. Wang S. Yu Q. Li Y. Yuan S. Discovering anti-cancer drugs via computational methods. Front. Pharmacol. 2020 11 733 10.3389/fphar.2020.00733 32508653
    [Google Scholar]
  34. Desai T.H. Joshi S.V. Anticancer activity of saponin isolated from Albizia lebbeck using various in vitro models. J. Ethnopharmacol. 2019 231 494 502 10.1016/j.jep.2018.11.004 30408535
    [Google Scholar]
  35. Kavitha C. Raja K.D. Rao S.K. Antitumor activity of Albizia lebbeck L. against Ehrlich ascites carcinoma in vivo and HeLa and A549 cell lines in vitro. J. Cancer Res. Ther. 2021 17 2 491 498 10.4103/jcrt.JCRT_454_19 34121697
    [Google Scholar]
  36. Malaikolundhan H. Mookkan G. Krishnamoorthi G. Matheswaran N. Alsawalha M. Veeraraghavan V.P. Krishna Mohan S. Di A. Anticarcinogenic effect of gold nanoparticles synthesized from Albizia lebbeck on HCT-116 colon cancer cell lines. Artif. Cells Nanomed. Biotechnol. 2020 48 1 1206 1213 10.1080/21691401.2020.1814313 33016139
    [Google Scholar]
  37. Shahidi F. Zhong Y. Measurement of antioxidant activity. J. Funct. Foods 2015 18 757 781 10.1016/j.jff.2015.01.047
    [Google Scholar]
  38. Padamanabhan V Ganapathy M Evanjelene VK Ayyavuv N Angamuthu J Invitro Antioxidant activity of Albizzia lebbeck (L) Benth. Int. J. Pharm. Med. 3 2 9 16
    [Google Scholar]
  39. khatoon M. Islam E. Islam R. Rahman A.A. Alam A.H.M.K. Khondkar P. Rashid M. Parvin S. Estimation of total phenol and in vitro antioxidant activity of Albizia procera leaves. BMC Res. Notes 2013 6 1 121 10.1186/1756‑0500‑6‑121 23531304
    [Google Scholar]
  40. Roglic G. WHO Global report on diabetes: A summary. Int. J. Noncommun. Dis. 2016 1 1 3 8 10.4103/2468‑8827.184853
    [Google Scholar]
  41. Jaiswal P. Kumar P. Alpha amylase inhibitory activity of different extract of bark of Albizia lebbeck (L.) benth. Int. J. Pharm. Pharm. Sci. 2017 9 8 119 122 10.22159/ijpps.2017v9i8.19411
    [Google Scholar]
  42. Ahmed D. Kumar V. Verma A. Gupta P.S. Kumar H. Dhingra V. Mishra V. Sharma M. Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats. BMC Complement. Med. Ther. 2014 14 1 243 10.1186/1472‑6882‑14‑243 25026962
    [Google Scholar]
  43. Ahmed D. Kumar V. Sharma M. Verma A. Target guided isolation, in-vitro antidiabetic, antioxidant activity and molecular docking studies of some flavonoids from Albizzia Lebbeck Benth. bark. BMC Complement. Altern. Med. 2014 14 1 155 10.1186/1472‑6882‑14‑155 24886138
    [Google Scholar]
  44. Samant S.S. Jagtap V.A. Kalangutkar P. Morye R. Gadekar A. Rane R. Desai S. Phytochemistry and therapeutic uses of Albizia lebbeck. Int. J. Herb. Med. 2023 11 5 22 26 10.22271/flora.2023.v11.i5a.884
    [Google Scholar]
  45. Phoraksa O. Chimkerd C. Thiyajai P. Judprasong K. Tuntipopipat S. Tencomnao T. Charoenkiatkul S. Muangnoi C. Sukprasansap M. Neuroprotective effects of Albizia lebbeck (L.) Benth. leaf extract against glutamate-induced endoplasmic reticulum stress and apoptosis in human microglial cells. Pharmaceuticals 2023 16 7 989 10.3390/ph16070989 37513900
    [Google Scholar]
  46. Vongthip W. Nilkhet S. Boonruang K. Sukprasansap M. Tencomnao T. Baek S.J. Neuroprotective mechanisms of luteolin in glutamate-induced oxidative stress and autophagy-mediated neuronal cell death. Sci. Rep. 2024 14 1 7707 10.1038/s41598‑024‑57824‑2 38565590
    [Google Scholar]
  47. Ayeni E.A. Gong Y. Yuan H. Hu Y. Bai X. Liao X. Medicinal plants for anti-neurodegenerative diseases in West Africa. J. Ethnopharmacol. 2022 285 114468 10.1016/j.jep.2021.114468 34390796
    [Google Scholar]
  48. Ayalew M. Bekele A. Mengistie M.G. Atnafie S.A. Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice. BMC Complement. Med. Ther. 2022 22 1 8 10.1186/s12906‑021‑03498‑6 34991582
    [Google Scholar]
  49. Srivastava V. Verma S. Panwar S. Deep P. Verma S. A brief review on phytopharmacological reports on Albizia procera. Asian J. Pharm. Pharmacol. 2020 6 2 144 149 10.31024/ajpp.2020.6.2.9
    [Google Scholar]
  50. Maroyi A. Treatment of diarrhoea using traditional medicines: Contemporary research in South Africa and Zimbabwe. Afr. J. Tradit. Complement. Altern. Med. 2016 13 6 5 10 10.21010/ajtcam.v13i6.2 28480353
    [Google Scholar]
  51. Tummers B. Green D.R. Caspase‐8: Regulating life and death. Immunol. Rev. 2017 277 1 76 89 10.1111/imr.12541 28462525
    [Google Scholar]
  52. Gupta R.S. Kachhawa J.B.S. Chaudhary R. Antispermatogenic, antiandrogenic activities of Albizia lebbeck (L.) Benth bark extract in male albino rats. Phytomedicine 2006 13 4 277 283 10.1016/j.phymed.2004.11.008 16492532
    [Google Scholar]
  53. Akintola O.O. Ogunbanjo O.R. Adeniran O.R. Abodunrin E.K. Ibode R.T. Remediation potential of Albizia lebbeck L. Benth. in chromium contaminated soil. J. For. Res. 2022 14 2 95 102
    [Google Scholar]
  54. Ozougwu O. Obimba K.C. Belonwu C.D. Unakalamba C.B. The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus. J. Physiol. Pathophysiol. 2013 4 4 46 57 10.5897/JPAP2013.0001
    [Google Scholar]
  55. Dello Russo C. Cappoli N. Coletta I. Mezzogori D. Paciello F. Pozzoli G. Navarra P. Battaglia A. The human microglial HMC3 cell line: Where do we stand? A systematic literature review. J. Neuroinflammation 2018 15 1 259 10.1186/s12974‑018‑1288‑0 30200996
    [Google Scholar]
  56. Patel M Chawla N Surani Z. Cancer Health of South Asians in the United States CRC Press 2017 47 69
    [Google Scholar]
  57. Abriham H. Paulos B. In vitro antioxidant and antibacterial activity of albizia lebbeck (L) benth stem bark. Sci. Technol. Arts Res. J. 2016 4 2 204 206 10.4314/star.v4i2.25
    [Google Scholar]
  58. Joshi A. Sengar N. Prasad S. Goel R. Singh A. Hemalatha S. Wound-healing potential of the root extract of Albizzia lebbeck. Planta Med. 2013 79 9 737 743 10.1055/s‑0032‑1328539 23677526
    [Google Scholar]
  59. VANI BK Phytochemical screening and biological studies on root bark of lebbek tree. Bulletin. Pharm. Med. Sci. 2014 2 1
    [Google Scholar]
  60. Sheyin Z Maimako J Shindang J Essien CU Bigwan EI Ede FR Antimicrobial activity of Albizia lebbeck leaf extract on some medically important bacteria. Int. J. Curr. Microbiol. Appl. Sci 2015 4 9 473 477
    [Google Scholar]
  61. Zumbroich TJ To Strengthen the teeth and harden the gums - Teeth blackening as medical practice in Asia, Micronesia and Melanesia Ethnobotany Research and Applications University of Hawaii at Manoa 2011 97 113
    [Google Scholar]
  62. Reyad-Ul-Ferdous M. Khan M.Z. Abdullah N. Nuri A. Evaluation of antimicrobial screening of barks and leaves extract of Albizia Lebbeck. World J. Pharm. Pharm. Sci. 2014 3 9 1478 1485
    [Google Scholar]
  63. Tomar VS Jawanjal VP A critical review on antitoxic formulations of Shirisha (Albizia lebbeck L.) WSRT major classics of Ayurveda. Pharm. Innov. 2019 8 149 154
    [Google Scholar]
  64. Kumar A. Saluja A.K. Shah U.D. Mayavanshi A.V. Pharmacological potential of Albizzia lebbeck: A review. Pharmacogn. Rev. 2007 1 1 171 174
    [Google Scholar]
  65. Kumar RP Ethno medicinal plants used for oral health care in India. Int. J. Herb. Med. 2014 2 1 81 87
    [Google Scholar]
  66. Gulati K Verma P Rai N Ray A Role of nutraceuticals in respiratory and allied diseases. Nutraceuticals Academic Press 2021 101 115 10.1016/B978‑0‑12‑821038‑3.00007‑0
    [Google Scholar]
  67. Mariod AA Mirghani ME Hussein IH Unconventional Oilseeds and Oil Sources 1st edElsevier 2017
    [Google Scholar]
  68. Warrier KC
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A Comprehensive Review of the Phytochemicals, Nutritional Values, and Therapeutic Applications of Albizia lebbeck
Bentham Science Publishers ; https://doi.org/10.2174/0115748855338072241122141859
/content/journals/cdth/10.2174/0115748855338072241122141859
/content/journals/cdth/10.2174/0115748855338072241122141859
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  • Article Type:     Review Article
Keywords: therapeutic actions ; Albizia lebbeck ; anti-hyperlipidemia ; phytochemicals ; nutrition

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