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image of Exploring the Multifaceted Potential of Kigelia africana: Journey from Ethnomedicine to Cosmeceutical

Abstract

Since ancient times, Indian or sausage trees have been utilized to heal a variety of human afflictions. Ethnobotanists have documented the traditional uses of , which include the management of skin conditions, cancer, and gynaecological problems. Scientists have been interested in assessing the bioactivity of plant components of . Numerous researchers have been most interested in its fruit and leaves due to their diverse pharmacological properties. has been used to develop items that are sold commercially, yet many of them lack complete standardization. It is necessary to carry out additional research, extract novel bioactive phytochemicals, standardize products, and scientifically confirm other traditional applications of ; despite numerous efforts by researchers to do so, many of these claims remain unsupported. The purpose of this review was to draw attention to 's undiscovered cosmetic potential.

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2024-11-04
2024-12-27
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References

  1. Nabatanzi A. M Nkadimeng S. Lall N. Kabasa J.D. J McGaw L. Ethnobotany, Phytochemistry and Pharmacological Activity of Kigelia africana (Lam.) Benth. (Bignoniaceae). Plants 2020 9 6 753 10.3390/plants9060753 32549404
    [Google Scholar]
  2. Tabuti J.R.S. Kukunda C.B. Kaweesi D. Kasilo O.M.J. Herbal medicine use in the districts of Nakapiripirit, Pallisa, Kanungu, and Mukono in Uganda. J. Ethnobiol. Ethnomed. 2012 8 1 35 10.1186/1746‑4269‑8‑35 22943789
    [Google Scholar]
  3. Chen S.L. Yu H. Luo H.M. Wu Q. Li C.F. Steinmetz A. Conservation and sustainable use of medicinal plants: problems, progress, and prospects. Chin. Med. 2016 11 1 37 10.1186/s13020‑016‑0108‑7 27478496
    [Google Scholar]
  4. Grace O.M. Light M.E. Lindsey K.L. Mulholland D.A. van Staden J. Jager A.K. Eloff J.N. Antibacterial activity and isolation of active compounds from fruit of the traditional African medicinal tree Kigelia africana. S. Afr. J. Bot. 2002 68 2 220 222 10.1016/S0254‑6299(15)30424‑5
    [Google Scholar]
  5. Priya B. Menkudale A. Gahlot M. Joshi P. Agarwal M. Pharmacognostical study, phytochemical analysis and phenolic content of Kigelia africana leaves. Int. J. Pharm. Pharm. Sci. 2013 5 163 166
    [Google Scholar]
  6. Chih-Cheng L. Lu-Te C. Yuan-Chen W. Yan-Hong T. Jia-Shang L. Boakye A. Glew R.H. Glew R.S. Polyphenol and Antioxidant Content of Kigelia africana Leaves from Ghana. Food 2012 6 1 5
    [Google Scholar]
  7. Singh A. Kumari S. Singh A.K. Singh N.K. Ethnopharmacology and pharmacology of Kigelia africana (Lam.). Benth. Int. J. Green Pharm. 2018 11 S23 S31
    [Google Scholar]
  8. Halder S. A Review on Kigelia africana. World J. Pharm. Res. 2017 6 389 411 10.20959/wjpr201711‑9633
    [Google Scholar]
  9. Dausdardt R. The changing geography of traditional medicine: urban herbalism on the Witwatersrand, SouthAfrica. Geography 1990 22 275 283
    [Google Scholar]
  10. van Wyk B.E. van Staden J. A review of ethnobotanical research in southern Africa. S. Afr. J. Bot. 2002 68 1 1 13 10.1016/S0254‑6299(15)30433‑6
    [Google Scholar]
  11. Dhungana B.R. Jyothi Y. Das K. Kigelia Pinnata: Exploration of Potential Medicinal Usage in Human Ailments. J. Pharm. Res. 2016 15 4 138 10.18579/jpcrkc/2016/15/4/108821
    [Google Scholar]
  12. Adam I.Y. Alhameed I.A. Kigelia africana fruits’ extracts anti hepato-toxic effects on male wistar rats liver destruction induced by CCL4. Asian J. Med. Sci. 2013 5 26 32
    [Google Scholar]
  13. Cragg G.M. Newman D.J. Medicinals for the millennia. Ann. N. Y. Acad. Sci. 2001 953a 1 3 25 10.1111/j.1749‑6632.2001.tb11356.x 11795420
    [Google Scholar]
  14. Sidjui S.L. Zeuko’o Menkem E. Marie R. Toghueo K. Olivier Noté O. Mahiou-Leddet V. Herbette G. Boyom F.F. Ollivier E. Folefoc G.N. SHORT REPORT Secondary metabolites from Jacaranda mimosifolia and Kigelia africana (bignoniaceae) and their anticandidal activity. Rec. Nat. Prod. 2014 83 307 311
    [Google Scholar]
  15. Burkill H.M. The Useful Plants of West Tropical Africa. Kew, UK Royal Botanic Gardens 1985 254 257
    [Google Scholar]
  16. Hussain T. Fatima K.F. Rafay M. Shabir S. Akram M. Bano S. Evaluation of antibacterial and antioxidant activity of leaves, fruit and bark of Kigelia africana. Pak. J. Bot. 2016 48 277 283
    [Google Scholar]
  17. Fitriyani D.P.S.G.S. Phytochemicals and cytotoxicity of sausage fruit (Kigelia africana) extract against breast cancer cells MCF-7 in vitro. J. Pharm. Res. 2018 12 288 292
    [Google Scholar]
  18. Olubunmi A. Olatunji A.G. Adeyemi O.S. Scott F.O. Antioxidant and antimicrobial activity of cuticular wax from Kigelia africana . FABAD J. Pharm. Sci. 2009 34 187 194
    [Google Scholar]
  19. Kakembo T. Sausage Tree Demystified. A Convert to Herbal Medicines Muses about the Sausage Tree Fruit in Kidepo Valley National Park. 2017
    [Google Scholar]
  20. Arkhipov A. Shalom J. Matthews B. Ian Edwin Cock I.E. Metabolomic profiling of Kigelia africana extracts with anti-cancer activity by high resolution tandem mass spectroscopy. Pharmacogn. Commun. 2014 4 10 32
    [Google Scholar]
  21. Sidjui L.S. Melong R. Leddet V.M. Herbette G. Tchinda A.T. Ollivier E. Folefoc G.N. Triterpenes and lignans from Kigelia africana. J. Appl. Pharm. Sci. 2015 5 1 6 10.7324/JAPS.2015.58.S1
    [Google Scholar]
  22. Jackson S.J. Houghton P.J. Retsas S. Photiou A. In vitro cytotoxicity of norviburtinal and isopinnatal from Kigelia pinnata against cancer cell lines. Planta Med. 2000 66 8 758 761 10.1055/s‑2000‑9778 11199138
    [Google Scholar]
  23. Patra A. Dey A.K. Kundu A.B. Saraswathy A. Purushothaman K.K. Shoreaphenol, a polyphenol from Shorea robusta. Phytochemistry 1992 31 7 2561 2562 10.1016/0031‑9422(92)83330‑2
    [Google Scholar]
  24. Zofou D. Kengne A.B.O. Tene M. Ngemenya M.N. Tane P. Titanji V.P.K. In vitro antiplasmodial activity and cytotoxicity of crude extracts and compounds from the stem bark of Kigelia africana (Lam.) Benth (Bignoniaceae). Parasitol. Res. 2011 108 6 1383 1390 10.1007/s00436‑011‑2363‑y 21487780
    [Google Scholar]
  25. Dorcas O. Moronkola D.O. Olaoluwa O.O. Oladosu I.A. Aboaba S.A. Aiyelaagbe O.O. Phytochemical and antimicrobial activities of extracts from six medicinal plants utilized as antimalarials in ethno-medicine. Pharmaceut. Chem. J. 2018 5 2 52 61
    [Google Scholar]
  26. Olatunji A.G. Olubunmi A. Comprehensive scientific demystification of Kigelia africana: A review. Afr. J. Pure Appl. Chem. 2009 3 158 16
    [Google Scholar]
  27. Atolani O. Olatunji G.A. Fabiyi O.A. Adeniji A.J. Ogbole O.O. Phytochemicals from Kigelia pinnata leaves show antioxidant and anticancer potential on human cancer cell line. J. Med. Food 2013 16 10 878 885 10.1089/jmf.2012.0249 24066943
    [Google Scholar]
  28. Moideen S.V.K. Houghton P.J. Rock P. Croft S.L. Aboagye-Nyame F. Activity of Extracts and Naphthoquinones from Kigelia pinnata Against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Planta Med. 1999 65 6 536 540 10.1055/s‑1999‑14011 10483374
    [Google Scholar]
  29. Iwu M.M. Obidoa O. Anazodo M. Biochemical mechanism of the antimalarial activity ofAzadirachta indica leaf extract. Pharmacol. Res. Commun. 1986 18 1 81 91 10.1016/0031‑6989(86)90161‑X 3081917
    [Google Scholar]
  30. Schleipeer M. Pharmaceutical or Cosmetic Preparation. Patent WO 2006/002443 A1, 2006.
  31. Patkar K. Herbal cosmetics in ancient India. Indian J. Plast. Surg. 2008 41 S 01 Suppl. 134 137 10.1055/s‑0039‑1700484 20174537
    [Google Scholar]
  32. Joshi B. Herbal Cosmetics: A Safe and Effective Approach. Available from:https://www.pharmatutor.org/articles/(accessed on 8-10-2024)
  33. Kuchekar B.S. Pharmaceutical Jurisprudence. Pragati Books Pvt. Ltd. 2008
    [Google Scholar]
  34. Kapoor V.P. Herbal cosmetics for skin and hair care. Nat. Prod. Radiance 2005 4 306 314
    [Google Scholar]
  35. Gediya S.K. Mistry R.B. Patel U.K. Blessy M. Jain H.N. Herbal plants: Used as a cosmetics. J Nat Prod Plant Resour 2011 1 24 32
    [Google Scholar]
  36. Bijauliya R.K. Alok S. Kumar M. Chanchal D.K. Yadav S. A comprehensive review on herbal cosmetics. Int. J. Pharm. Sci. Res. 2017 8 4930 4949
    [Google Scholar]
  37. Castanet J. Ortonne J.P. Pigmentary changes in aged and photoaged skin. Arch. Dermatol. 1997 133 10 1296 1299 10.1001/archderm.1997.03890460120015 9382570
    [Google Scholar]
  38. Chung J.H. Hanft V.N. Kang S. Aging and photoaging. J. Am. Acad. Dermatol. 2003 49 4 690 697 10.1067/S0190‑9622(03)02127‑3 14512918
    [Google Scholar]
  39. Rabe J.H. Mamelak A.J. McElgunn P.J.S. Morison W.L. Sauder D.N. Photoaging: Mechanisms and repair. J. Am. Acad. Dermatol. 2006 55 1 1 19 10.1016/j.jaad.2005.05.010 16781287
    [Google Scholar]
  40. Assanti G. Kaur R. Nizard S. Pollack-Blackwood E. Rafferty B. Priano C. Fernández Romero J.A. Koroch A.R. Biology, chemistry, and pharmacological activity of Kigelia africana (Bignoniaceae) and Garcinia kola (Clusiaceae) - a review. J Med Act Plants. 2022 11 1 1 21 38234457
    [Google Scholar]
  41. Glaser D.A. Anti-ageing products and cosmeceuticals. Facial Plast Surg. Clin N Am 2004 12 4 363 372 15261173
    [Google Scholar]
  42. Shivanand P. Nilam M. D.Viral, Herbs Play an Important Role in the Field of Cosmetics. Int. J. Pharm. Tech. Res. 2010 2 1 632 639
    [Google Scholar]
  43. Imran I.Z. Elusiyan C.A. Agbedahunsi J.M. Omisore N.O. Bioactivity-directed evaluation of fruit of Kigelia africana (Lam.) benth. Used in treatment of malaria in Iwo, Nigeria. J. Ethnopharmacol. 2021 268 113680 10.1016/j.jep.2020.113680 33301913
    [Google Scholar]
  44. Mortensen A. Skibsted L.H. Relative stability of carotenoid radical cations and homologue tocopheroxyl radicals: A real time kinetic study of antioxidant hierarchy. FEBS Lett. 1997 417 2 261 266 10.1016/s0014‑5793(97)01297‑0
    [Google Scholar]
  45. Shanbhag S. Nayak A. Narayan R. Nayak U.Y. Anti-aging and sunscreens: paradiam shift in cosmetics. Adv. Pharm. Bull. 2019 9 3 348 359 10.15171/apb.2019.042 31592127
    [Google Scholar]
  46. Truswell W.H. Prescription skin care products and skin rejuvenation. Facial Plast. Surg. Clin. North Am. 2020 28 1 59 65 10.1016/j.fsc.2019.09.005 31779942
    [Google Scholar]
  47. King B.J. The history and evolution of skin resurfacing. Lasers and light peels and abrasions—applications and techniques. Truswell W.H. New York Thieme Medical Publishers 2016 1
    [Google Scholar]
  48. Alves A. Sousa E. Kijjoa A. Pinto M. Marine-derived compounds with potential uses as cosmeceutical and nutricosmetics. Molecules 2020 25 11 2536 10.3390/molecules25112536 32486036
    [Google Scholar]
  49. Smit N. Vicanova J. Pavel S. The hunt for natural skin whitening agents. Int. J. Mol. Sci. 2009 10 12 5326 5349 10.3390/ijms10125326 20054473
    [Google Scholar]
  50. Chiu A. Kimball A.B. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br. J. Dermatol. 2003 149 4 681 691 10.1046/j.1365‑2133.2003.05540.x 14616358
    [Google Scholar]
  51. Charles Dorni A.I. Amalraj A. Gopi S. Varma K. Anjana S.N. Novel cosmeceuticals from plants—An industry guided review. J. Appl. Res. Med. Aromat. Plants 2017 7 1 26 10.1016/j.jarmap.2017.05.003
    [Google Scholar]
  52. Aburjai T. Natsheh F.M. Plants used in cosmetics. Phytother. Res. 2003 17 9 987 1000 10.1002/ptr.1363 14595575
    [Google Scholar]
  53. Song R. Wu Q. Yun Z. Zhao L. Advances in Antioxidative Bioactive Macromolecules. IOP Conf. Ser. Earth Environ. Sci. 2020 512 1 012094 10.1088/1755‑1315/512/1/012094
    [Google Scholar]
  54. Wölfle U. Seelinger G. Bauer G. Meinke M.C. Lademann J. Schempp C.M. Reactive molecule species and antioxidative mechanisms in normal skin and skin aging. Skin Pharmacol. Physiol. 2014 27 6 316 332 10.1159/000360092 24994069
    [Google Scholar]
  55. Ndiaye M.A. Nihal M. Wood G.S. Ahmad N. Skin, reactive oxygen species, and circadian clocks. Antioxid. Redox Signal. 2014 20 18 2982 2996 10.1089/ars.2013.5645 24111846
    [Google Scholar]
  56. Jadoon S. Karim S. Asad M.H.H.B. Akram M.R. Kalsoom Khan A. Malik A. Chen C. Murtaza G. Anti-aging potential of phytoextract loaded-pharmaceutical creams for human skin cell longevity. Oxid. Med. Cell. Longev. 2015 2015 1 17 10.1155/2015/709628 26448818
    [Google Scholar]
  57. Nishigori C. Hattori Y. Arima Y. Miyachi Y. Photoaging and oxidative stress. Exp. Dermatol. 2003 12 s2 Suppl. 2 18 21 10.1034/j.1600‑0625.12.s2.3.x 14756519
    [Google Scholar]
  58. Pham-Huy L.A. He H. Pham-Huyc C. Free radicals, antioxidants in disease and health. Int. J. Biomed. Sci. 2008 4 2 89 96 10.59566/IJBS.2008.4089 23675073
    [Google Scholar]
  59. Chandrasekaran A. Idelchik M.P.S. Melendez J.A. Redox control of senescence and age-related disease. Redox Biol. 2017 11 91 102 10.1016/j.redox.2016.11.005 27889642
    [Google Scholar]
  60. Lobo V. Patil A. Phatak A. Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev. 2010 4 8 118 126 10.4103/0973‑7847.70902 22228951
    [Google Scholar]
  61. Powers S.K. Ji L.L. Kavazis A.N. Jackson M.J. Reactive oxygen species: impact on skeletal muscle. Compr. Physiol. 2011 1 2 941 969 10.1002/cphy.c100054 23737208
    [Google Scholar]
  62. Venkataraman K. Khurana S. Tai T. Oxidative stress in aging--matters of the heart and mind. Int. J. Mol. Sci. 2013 14 9 17897 17925 10.3390/ijms140917897 24002027
    [Google Scholar]
  63. Genestra M. Oxyl radicals, redox-sensitive signalling cascades and antioxidants. Cell Signal 2007 19 9 1807 1819 10.1016/j.cellsig.2007.04.009
    [Google Scholar]
  64. Oliver R.F. Barker H. Cooke A. Grant R.A. Dermal collagen implants. Biomaterials 1982 3 1 38 40 10.1016/0142‑9612(82)90059‑X 7066465
    [Google Scholar]
  65. Li Y. Lei D. Swindell W.R. Xia W. Weng S. Fu J. Worthen C.A. Okubo T. Johnston A. Gudjonsson J.E. Voorhees J.J. Fisher G.J. Age-Associated Increase in Skin Fibroblast–Derived Prostaglandin E 2 Contributes to Reduced Collagen Levels in Elderly Human Skin. J. Invest. Dermatol. 2015 135 9 2181 2188 10.1038/jid.2015.157 25905589
    [Google Scholar]
  66. Fisher G.J. Datta S.C. Talwar H.S. Wang Z.Q. Varani J. Kang S. Voorhees J.J. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 1996 379 6563 335 339 10.1038/379335a0 8552187
    [Google Scholar]
  67. Fisher G.J. Wang Z. Datta S.C. Varani J. Kang S. Voorhees J.J. Pathophysiology of premature skin aging induced by ultraviolet light. N. Engl. J. Med. 1997 337 20 1419 1429 10.1056/NEJM199711133372003 9358139
    [Google Scholar]
  68. Flatt T. A new definition of aging? Front. Genet. 2012 3 148 10.3389/fgene.2012.00148 22936945
    [Google Scholar]
  69. Beckman K.B. Ames B.N. The free radical theory of aging matures. Physiol. Rev. 1998 78 2 547 581 10.1152/physrev.1998.78.2.547 9562038
    [Google Scholar]
  70. Pole A. Dimri M. Dimri G. Oxidative stress, cellular senescence and ageing. AIMS Mol. Sci. 2016 3 3 300 324 10.3934/molsci.2016.3.300
    [Google Scholar]
  71. Nworu C.S. Akah P.A. Anti-inflammatory medicinal plants and the molecular mechanisms underlying their activities. Afr. J. Tradit. Complement. Altern. Med. 2015 12 6 52 61 10.4314/ajtcam.v12i6.3S
    [Google Scholar]
  72. Atolani O. Olatunji A.G. Epicuticular Wax and Volatiles of Kigelia pinnata Leaf Extract. Ethnobotan Leafl. 2010 14 797 806
    [Google Scholar]
  73. Owolabi O.J. Omogbai E.K. Analgesic and anti- inflammatory Activities of Ethanolic Stem Bark Extract of Kigelia Africana (Bignoniacea). Afr. J. Biotechnol. 2007 6 5 582 585
    [Google Scholar]
  74. Emeka G. Emmanuel N. Victor N.S.I. Effect of Methanol Leaf and Fruit Extracts of Kigelia africana on Some Biochemical Parameters of Normal Albino Rats. World Appl. Sci. J. 2014 31 1689 1694
    [Google Scholar]
  75. Olalye M.T. Rocha J.B.T. Commonly used tropical medicinal plants exhibt distinct in vitro antioxidant activities against hepatotoxins in rat liver. Exp. Toxicol. Pathol. 2007 58 6 433 438 10.1016/j.etp.2007.01.002 17395447
    [Google Scholar]
  76. Changoer L. George Anastassov Topical cosmetic Prepration. Patent ES86052T3, 2021.
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