Current Drug Metabolism - Volume 18, Issue 12, 2017

Background: Salvia is the largest genus of family Lamiaceae and has nearly 1000 species. This genus produces several representative phytometabolites, e.g., diterpenoids and phenolic acids. The traditional uses in ethnomedicine and contemporary experimental studies have corroborated extensive therapeutic efficacy of Salvia plants. Drug metabolism and pharmacokinetic (DMPK) studies of Salvia natural pro Read More

Background: Salmonella enterica serovar typhimurium is the most important serotype of Salmonella transmitted from animals to humans in most parts of the world. They are associated with an estimated 1 million deaths annually. Quinolones, an important class of broad-spectrum antimicrobials, have been utilized as a treatment option for salmonellosis for over 40 years. Despite the number of available quinolone a Read More

Background: Cancer cells use several mechanisms to resist the cytotoxic effects of drugs, resulting in tumor progression and invasion. One such mechanism capitalizes on the body's natural defense against xenobiotics by increasing the rate of xenobiotic efflux and metabolic inactivation. Xenobiotic metabolism typically involves conversion of parent molecules to more soluble and easily excreted derivatives in reactions cat Read More

Background: Absorption, Distribution, Metabolism, Excretion (ADME) properties along with drug induced adverse effects are the major reasons for the late stage failure of drug candidates as well as the cause for the expensive withdrawal of many approved drugs from the market. Considering the adverse effects of drugs, metabolism factor has great importance in medicinal chemistry and clinical pharmacology because it influ Read More

Background: Metabolism of therapeutic agents in organism is extremely important from a point of view of drug discovery. Unfortunately, experimental estimation of phenomena related to metabolism is available for the limited number of substances. Under such circumstances, the development of computational method to predict endpoints related to metabolism of therapeutic agents becomes an attractive alternat Read More

Background: The study of the mechanisms of liver regeneration is quite an intriguing field that has been extensively modeled. Through the process of compensatory proliferation of the hepatocytes, the liver mass is restored after loss of up to two-thirds of the entire mass. Cyclic nucleotides are intracellular second messengers which are involved in the transduction of a diverse array of stimuli, mediating metabolic and growth re Read More

Background: Despite major advances in transplant medicine, antibody-mediated rejection (AMR) continues to have severe clinical implications and adversely affect graft survival. Therefore, the search for alternative drugs to treat AMR is widely pursued. The first-in-class proteasome inhibitor bortezomib (BZ) is a selective inhibitor of the 26S proteasome, which was initially approved for the treatment of malignant plasma cell d Read More

Background: Lysosomotropic molecules are taken up into lysosomes in vitro and in vivo. Many drugs approved for clinical medicine are lysosomotropic agents, characterized by promoting particular effects including cytoplasmic vacuolization, increase in number and size of lysosomes, inhibition of their enzymes and accumulation of undegraded material, leading mainly to phospholipidosis. Despite lysosomotr Read More