Current Drug Metabolism - Volume 18, Issue 11, 2017

Background: Recently, pharmaceutical research has focused on in vitro-in vivo correlation as a novel challenge, and in silico modeling has been an important component. As in silico models are highly representative of practical use, regulatory agencies such as the US Food and Drug Administration and European Medicines Agency have recognized and utilized in silico modeling as a useful tool; this allows pharmaceutic Read More

Background: Nanostructured material is a solid substance with at least one face is in the range of 1-100 nm. Manipulations in the characteristics and effects of nanostructures can invent new procedures and technologies, as the physical and chemical properties of nanomaterials are noticeably dissimilar from those of a single atom or its bulk phase. This difference in the properties is due to different spatial arrangeme Read More

Background: More than 60% of the active pharmaceutical ingredients, which are classified as Biopharmaceutics Classification System class II. The limited solubility of these drug may lead to low therapeutic effects. Methods: Nanoprecipitation presents some advantages because it is a straightforward method with low-cost equipment that is easy to scale up. Results: However, there are two technical issues of concern rel Read More

Background: Efficient colon-specific drug delivery has been demonstrated recently in the treatment of various diseases, including Crohn's disease, ulcerative colitis (inflammatory bowel disease), and colorectal cancer. Methods: Of all strategies, the conjugation of a model drug to a carrier (with or without spacers) has been recognized as promising for targeting the colon. Results: This is because the conjugation method releases l Read More

Background: Recently the decoration of graphene with metallic nanoparticles by a synchronized reduction of graphene oxide (GO) and synthesis of metallic nanoparticles has gained momentum. Metal-decorated carbon substrates, for example, carbon nanotubes and graphene oxide have been of interest to the scientific group all through the past three decades on account of different potential applications. The utilization of grap Read More

Background: The first-line TB antibiotic isoniazid (INH) serves as a central component of combined first-line anti-tuberculosis drug therapy. However, resistance to INH has hindered the functioning of this drug. Resistance is caused by several known and unknown mutations in genes/regions in Mycobacterium tuberculosis (M. tuberculosis), followed by selection of these mutants in the presence of the drug. INH r Read More

Background: The urge for the development and manufacture of new and effective antimicrobial agents is particularly demanding especially in the present scenario of emerging multiple drug resistant microorganisms. A promising initiative would be to converge nanotechnology to develop novel strategies for antimicrobial treatment. These distinct nano scale properties confer impressive antimicrobial capabilities to nanomaterials Read More

Background: Gold nanoparticles have been exploited for nanobiotechnology applications for the last two decades. New insights of the nanomaterials as promising agent for cancer diagnosis and therapy have just started to emerge. Due to the size- and shape-dependent optical, electrical and thermal properties, gold nanoparticles are being developed as diagnostic reagents, drug carriers, contrast agents, photot Read More