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Comparative in Vitro Metabolic Profile Study of Five Cathinone Derivatives
Authors: Zexuan Li, Sufang Xiang, Tian Zheng, Guoping Wu and Liang WuAvailable online: 17 March 2025More LessBackground Cathinone derivatives as new psychoactive substances have attracted worldwide attention in recent years. They have strong excitatory effects on the human central nervous system, which is extremely abusive and harmful. As they are easy to be structurally modified, and rapidly metabolized and excreted after taken, clarifying their metabolic profile is of significant importance to provide useful information for thei Read More
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A Review on Drug-Metabolizing Enzymes, Transporters, and Gut Microbiota on Pharmacokinetics in High-Altitude Environment
Authors: Fangfang Qiu, Yuemei Sun, Wenbin Li and Rong WangAvailable online: 11 February 2025More LessThe most significant feature of the high-altitude environment is hypoxia, which affects the activity and expression of drug-metabolizing enzymes and transporters, leading to changes in pharmacokinetic parameters. Notably, gut microbiota is a hidden organ in the body. High-altitude hypoxia will change the composition and quantity of gut microbiota, affect drug metabolism, and change the bioavailability of drugs. This will pro Read More
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Exploring Drug-Drug Interactions between Losartan and Carbamazepine: A Pharmacokinetic and Pharmacodynamic Study
Authors: Shruthi A Sundargowda and Sunil Kumar KadiriAvailable online: 23 January 2025More LessBackground Hypertension, which affects 1.28 billion people globally aged 30 to 79, is characterized by continuously high blood pressure (140/90 or more) and raises the risk of premature death. Losartan, an angiotensin receptor blocker (ARB), is suggested for patients under the age of 55 who cannot take ACE inhibitors as a first treatment option. Epilepsy, a chronic neurological illness marked by repeated seizures, affects more Read More
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