Current Cancer Therapy Reviews - Volume 14, Issue 1, 2018

Purpose: To explore the role of stereotactic body radiotherapy (SBRT) in the management of primary or metastatic liver cancer. Materials and Methods: A systematic search of the PubMed database was conducted to identify indications and patient selection criteria, technique and dose prescription, oncologic outcomes and side effects of stereotactic body radiotherapy (SBRT) for liver cancer. Results: The role for radioth Read More

Background: Stereotactic body radiotherapy (SBRT) is a recent addition to the armamentarium for treating clinically localized prostate cancer. SBRT is a special form of image-guided radiotherapy (IGRT) that involves the delivery of a small number of very high-dose fractions (e.g. 35 to 40 Gy, in 4 to 5 fractions). The slow-growing nature of prostate adenocarcinoma is thought to be associated to a low α[alpha]/β[beta] ratio of ~1.5, Read More

Background: Pancreatic cancer is a difficult malignancy to manage with little improvement in mortality rates over time. Local control remains a challenge. The objective of this review is to discuss patient selection and technical considerations for the safe utilization of stereotactic body radiotherapy (SBRT). Methods: An online search was completed to review available data. The current literature examining the use and d Read More

Introduction: The role of stereotactic radiosurgery is increasing in the management of brain and spine metastases. We review the data supporting its use. Methods: We used data to compile recommendations for indications, prescription dose and dose constraints, treatment outcomes, and toxicities. Results: Stereotactic radiosurgery is demonstrated to be effective and safe in the management of brain and spine metastases, Read More

Background: Stereotactic body radiotherapy (SBRT) or radiosurgery has emerged as a viable highly precise technique that delivers a hypofractionated radiotherapy regimen with a high biologic effective dose. In addition to patient convenience, this dose is thought to provide acceptable local control while keeping toxicity to a minimum due to the typical small target size. The aims of this paper are to review re Read More

Background: Colorectal cancer (CRC) also known as bowl cancer is still one of the leading causes of cancer related mortality worldwide. Generally tumor cells are protecting themselves by fibrin coat and it is resistant to fibrinolytic degradation. Such a coated tumor appears as ‘self’ to the immune system, and thus is not detected as a tumor by the immune system (i.e. natural killer cells). Hence, a potent proteolytic enzyme Read More