Current Cancer Therapy Reviews - Volume 13, Issue 1, 2017

Background: Over expression of epidermal growth factor receptor (EGFR) has been found to play a vital role in cancer of lung and pancreas. Therapies that target EGFR-mediated signalling are the latest keystone for treating these two types of cancer. Methodology: Erlotinib is an EGFR tyrosine kinase inhibitor, a promising anticancer agent either alone or as combination therapy for the treatment of both lung and pancr Read More

Background: Cancer is one of the most dreadful diseases all over the world that can cause death. Cancer could be treated with different methods such as surgery, chemotherapy or radiotherapy. Methodology: In this review study, various techniques in cancer treatment especially radiotherapy modalities including three dimensional radiation therapy, intensity modulated radiation therapy, image guided radiation therapy, intra o Read More

Background: Multi Drug Resistance (MDR) is one of the main hindrances in the successful treatment of cancer by natural agents. Most of the natural anticancer drugs are effluxed by the P-glycoprotein resulting in the failure of cancer chemotherapy. Phenothiazines and related drugs are one of the first drugs investigated for the reversal of MDR. Exhaustive studies have been done to develop potent phenothiazines analogu Read More

Background: Angiogenesis stands as a symbol for the development of tumor as well as its metastasis. In this review, we discuss the various components that induce and enhance angiogenesis along with its several inhibitors in neuroblastoma. Angiogenesis is vital for tumor development and migration and it is dependent on the creation of angiogenic elements by tumor cell lines. Methodology: Neuroblastoma (NB) is a gen Read More

Background: Significant shortcomings have been displayed in conventional chemotherapeutics delivery which possesses some genuine side effects including harm of the immunity and different organs with quickly multiplying cells because of nonparticular focus on the absence of dissolvability and powerlessness to enter the tumor core bringing about debilitated treatment with diminished dosage and with low survival rate. Rapi Read More