Current Cancer Therapy Reviews - Volume 12, Issue 1, 2016

With advances in diagnosis and treatment, breast cancer has become an increasingly survivable disease with a growing population of long-term survivors. As an essential component of breast conservation therapy, radiotherapy is a standard treatment for many women with stage I/II breast cancer. Cardiac radiation exposure has been associated with an increased risk of cardiovascular diseases. Among these are coronary ar Read More

Merkel cell carcinoma (MCC) is an aggressive cutaneous malignancy with neuroendocrine origin. The rarity of the tumor and variable clinical presentation make the diagnosis especially challenging. The tumor grows rapidly and lymph node metastasis occurs early in the disease course. The etiology is related to prior UV exposure, immunosuppression, and polyomavirus infection. The 2008 discovery of an infectious cause Read More

High grade serous (HGS) cancer of the ovary (OC) is a lethal malignancy with advanced stage disease remaining incurable. HGS OC is sensitive to platinum based chemotherapy with complete responses being frequent, but relapses are inevitable, with resistance invariably emerging. Deeper understanding of the pathogenesis of HGS OC with new sequencing techniques shows that aberrations in the BRCA pathway may play a Read More

Breast cancer is the most common malignancy in women worldwide and the most common cause of cancer mortality in women. Seventy percent of breast cancers overexpress the estrogen (ER) and/or the progesterone receptor (PgR) making anti-endocrine therapies the most commonly used worldwide for this disease. These therapies are of low toxicity and low cost since most of them are off-patent and therefore very valuabl Read More

Over the last decade, Antibody Drug Conjugates (ADCs) have gained a great success due to their documented clinical efficacy and manageable toxicity. Generally the word “drug” is associated with a chemotherapeutic drug, however “drug” can also be associated with other cytotoxic payloads such as radionuclides, termed more specifically, Antibody Radionuclide Conjugates (ARCs) for radioimmunotherapy (RIT). A lar Read More

Cancer is characterized as the second leading cause of death worldwide despite several therapies. In this regard, numerous researchers around the world are working on synthetic and natural products for the discovery of novel effective anticancer agents. Plants have been used in the treatment of various diseases and they have also shown tremendous potential in the treatment of cancer. This mini review has focused Read More