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Volume 21, Issue 2
  • ISSN: 1573-3947
  • E-ISSN: 1875-6301

Abstract

Background

Thunb. (Asteraceae) is a commonly used medicinal plant for gastric and appetite-associated complications in traditional Chinese medicine. The rhizome of has been widely used for the treatment of human complications. Atractylodin has anti-angiogenic, anti-cancer, anti-inflammatory, anti-microbial, anti-pyretic and anti-hypertensive potential in medicine. Nano-formulations of atractylodin were also prepared in the scientific field to enhance its water solubility and efficacy in cholangiocarcinoma.

Methods

Health-beneficial aspects of atractylodin in medicine have been investigated in the present work through collected scientific information on atractylodin from different literature databases. Scientific data on atractylodin has been collected from Google, Science Direct, Scopus, and PubMed. Further, detailed pharmacological activities and analytical aspects of atractylodin were discussed in this paper in order to know its biological potential in medicine. Analytical techniques of atractylodin were also discussed in the present work for separation, isolation, and identification of atractylodin.

Results

Scientific data analysis signified the biological importance of Thunb. and its active phytochemical atractylodin in medicine. Scientific data signified the presence of atractylodin in and . Atractylodin has a significant biological effect on cholangiocarcinoma, hepatocellular carcinoma, breast cancer, lung cancer, cancer anorexia-cachexia syndrome, colitis, rheumatoid arthritis, respiratory complications, GIT complications, hepatic complications, atopic dermatitis, aging process, neurodegenerative disease, calcified aortic valve disease, hypertension, pulmonary fibrosis, body temperature, olfactory neurons, podocyte hypermotility and toxicity. Further, its anti-nociceptive, anti-fibrotic, anti-angiogenic, anti-virulence, anti-bacterial, insecticidal, lipase inhibitory potential, immunomodulatory, and positive inotropic effects were also discussed in the present paper. Analytical techniques for the separation, isolation and identification of atractylodin in different samples were also discussed in the present work.

Conclusion

The present work's scientific data signified the biological importance of atractylodin in medicine.

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2025-04-19

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/content/journals/cctr/10.2174/0115733947265189231129105327
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Biological Potential and Therapeutic Effectiveness of a Polyethylene Alkyne Class Phytochemical ‘Atractylodin’ in Medicine for the Treatment of Cancer and other Human Complications
Curr Cancer Ther Rev 21, 154 (2025); https://doi.org/10.2174/0115733947265189231129105327
/content/journals/cctr/10.2174/0115733947265189231129105327
/content/journals/cctr/10.2174/0115733947265189231129105327
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  • Article Type:     Review Article
Keyword(s): analytical; Atractylodes lancea; Atractylodin; cancer; medicine; pharmacological

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