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Current Cardiology Reviews - Online First
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Assessment of Left Ventricular Shape Index and Eccentricity Index as Promising Parameters for Detection of Left Ventricular Remodeling in Cardiovascular Events
Available online: 17 March 2025More LessLeft ventricular remodeling (LVR) refers to the changes in the size, shape, and function of the left ventricle, influenced by mechanical, neurohormonal, and genetic factors. These changes are directly linked to an increased risk of major adverse cardiac events (MACEs). Various parameters are used to assess cardiac geometry across different imaging modalities, with echocardiography being the most commonly Read More
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Trends in Readmissions Rates and Mortality after Cardiac Resynchronization Therapy in Patients with Nonischemic Cardiomyopathy
Available online: 03 March 2025More LessIntroduction Advances in cardiac implanted electronic devices (CIED) have significantly improved outcomes for patients with heart failure. However, there is a bereft of recent real-world data on the relative effectiveness of cardiac resynchronization therapy with pacing and defibrillator (CRT-D) and continuous resynchronization therapy with pacing (CRT-P) in patients with nonischemic cardiomyopathy (NICM). We hypothesized th Read More
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Non-Bacterial Thrombotic Endocarditis in Lung Cancer: A Systematic Review
Available online: 11 February 2025More LessIntroduction Nonbacterial Thrombotic Endocarditis (NBTE) is a rare condition characterized by aseptic vegetations of the heart valves, predisposing to valvular dysfunction and end-organ infarction. Lung Cancer (LC) is amongst the most common malignancies associated with NBTE. Methods PubMed/MEDLINE was searched from database inception until January 2024, pairing “Non-Bacterial Thrombotic Endocarditis (NBTE) and Read More
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The Impact of Novel Lipid-Lowering Agents on Cardiovascular Risk Reduction: A Systematic Review and Meta-Analysis
Available online: 11 February 2025More LessIntroduction Reducing the risk of atherosclerotic cardiovascular disease is the aim of lipid-lowering therapy (ASCVD). It is commonly acknowledged that low-density lipoprotein (LDL) is a major cause of ASCVD. Several online databases and search engines, such as PubMed and the Cochrane Library, were used to conduct a thorough search. Method This study included RCTs assessing the effect of PCSK9 inhibitors on cardiovas Read More
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The Role of Red Blood Cells in Cholesterol Accumulation and Atherosclerotic Plaque Instability: A Perspective on Atherosclerosis
Authors: Reza Mohebbati and Mohammad Amin Momeni MoghaddamAvailable online: 11 February 2025More LessAtherosclerosis stands as the primary cause of CVD, characterized by the accumulation of cholesterol deposits within macrophages in medium and large arteries. This deposition promotes the proliferation of specific cell types within the arterial wall, gradually narrowing the vessel lumen and impeding blood flow. Intra-plaque hemorrhages are recognized as critical events in atherosclerotic plaques, leading to the deposition of Read More
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Effects of Physical Exercise and the Use of Doxorubicin on Cardiac Function in Rodents: A Systematic Review and Meta-Analysis
Available online: 10 February 2025More LessBackground Anthracycline-based chemotherapy, such as Doxorubicin (DOX), often induces cardiotoxicity in cancer patients, which compromises their health and quality of life. Objective This study aimed to verify the effects of exercise concomitant with prolonged administration of DOX on improving cardiotoxicity. Methods: A systematic literature search in MedLine, PubMed, Web of Science, and Scopus databases was perfo Read More
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The Use of Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) for Acute High Risk Pulmonary Embolism: A Systematic Review
Authors: Rohit Munagala, Humail Patel, Pranav Sathe, Avneet Singh and Mangala NarasimhanAvailable online: 10 February 2025More LessIntroduction Pulmonary embolism (PE) associated with hemodynamic compromise, termed high-risk or massive acute PE (MAPE), is associated with increased morbidity and mortality. Despite advancements in procedural techniques and an increase in the availability of advanced therapies, the outcomes associated with high-risk PE remain poor. Here, we review the literature surrounding the use of Veno-arterial Extracorporeal Read More
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Leptin Resistance and Cardiometabolic Disorders: Bridging Molecular Pathways, Genetic Variants, and Therapeutic Innovation
Authors: Prashanjit Roy, Rishi kant, Amandeep kaur, Hardik Kumar and Ranjeet KumarAvailable online: 07 February 2025More LessLeptin, a hormone produced by fat cells, is crucial for regulating energy equilibrium, managing body mass, and influencing metabolic and cardiovascular well-being. Leptin decreases appetite, boosts energy usage, and has a significant impact on glucose metabolism by primarily activating the JAK2/STAT3 signaling pathway in the hypothalamus. Obesity leads to the development of leptin resistance, which is marke Read More
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Pharmacogenomics and its Role in Cardiovascular Diseases: A Narrative Literature Review
Available online: 31 January 2025More LessPharmacogenomics has transformed the way we approach the treatment of the most common diseases worldwide, especially cardiovascular. In this article, we highlight the main categories of drugs involved in major cardiovascular diseases (CVD), related genetic variability and their effects on metabolism in each case of contrastive operability. This not only explains disparities in treatment outcomes but also unfolds customis Read More
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Evaluation of the Effect of Virgin Rice Bran Oil (VRBO) on Doxorubicin-Induced Cardiotoxicity in Wistar Rats
Authors: S. Prema, Rakesh Verma, Amritesh Nagarwal, Meenakshi Bharkatiya, Madhuri Baghel, Ladli Kishore, Pranay Wal and Amin GasmiAvailable online: 28 January 2025More LessObjective The usage of doxorubicin (DOX), an antineoplastic drug that is frequently used for the cure of cancer, is restricted to maximal doses due to its cardiac toxicity. Reactive oxygen species produced by DOX result in lipid peroxidation and organ failure, ultimately resulting in cardiomyopathy. Due to its high polyphenol content, virgin rice bran oil (VRBO) is a diet nutritional supplement with a strong antioxidant. Read More
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Exploring the Involvement of New Members of the Interleukin Family in Cardiovascular Disease
Available online: 21 January 2025More LessCardiovascular diseases remain a significant reason for illness and death globally. Although certain interleukins have been extensively researched about cardiovascular disease (CVD), new findings have identified unique members of the interleukin family that could potentially play a role in cardiovascular well-being and ailments. This review discusses the current understanding of the role of these recently identified interleuki Read More
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A New Mechanism of Supraventricular Tachycardia: Gene Mutation
Authors: Jie Gao, Rong Luo and Xiaoping LiAvailable online: 20 January 2025More LessBackground Supraventricular tachycardia (SVT) is very common in daily clinical practice, especially in the emergency department, with rapid onset and urgent management. The review highlights the recent genetic predispositions and mechanisms in SVT. Methods Through analysis of epidemiology, familial clustering, and gene mutations of the relevant literature,the review elucidates the genetic properties and potentia Read More
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