Combinatorial Chemistry & High Throughput Screening - Volume 13, Issue 8, 2010

Analytical chemistry is one of the oldest scientific disciplines. The development of chemistry itself has progressed significantly by analytical findings over several centuries. In recent times, analytical chemistry has stimulated not only chemistry but many fields of science, technology and society. Conversely, analytical chemistry itself has always been heavily influenced by fields like environmental protection, biology, and medicine. Read More

A biomimetic sensor is proposed as a promising new analytical method for determination of captopril in different classes of samples. The sensor was prepared by modifying a carbon paste electrode with iron (II) phthalocyanine bis(pyridine) [FePc(dipy)] complex. Amperometric measurements in a batch analytical mode were first carried out in order to optimize the sensor response. An applied potential lower than 0.2 V vs Ag|Ag Read More

Colorimetric and atomic absorption spectrometric methods have been developed for the determination of mucolytic drug Ambroxol. These procedures depend upon the reaction of iron(III) metal ion with the drug in the presence of thiocyanate ion to form stable ion-pair complex which is extractable in chloroform. The red-colored complex was determined either colorimetrically at 510 nm or by indirect atomic absorption s Read More

A novel oral controlled delivery system for benzydamine hydrochloride (BN) was developed and optimized. Hydrophilic matrix tablets of BN were prepared by using hydroxypropylmethylcellulose (HPMC) and chitosan as polymer substance to achieve required sustained release profile. The matrix tablets were prepared by both direct compression and wet granulation method. The influence of matrix forming agents and bina Read More

Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10-10 and 10-7 mol/L and be Read More

The anodic voltammetric behavior and electroanalytical determination of rosiglitazone were studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques on a glassy carbon electrode. The oxidation of rosiglitazone was irreversible and exhibited diffusion controlled process depending on pH. Different parameters were tested to optimize the conditions for the determination of the oxidation Read More

This paper is the first report describing the characterization of local diatomite of Caldiran-Van region (Eastern Anatolia, Turkey). Special attention was paid to the ability of its electroanalytical performance at modified electrodes and to the potential application of diatomite-modified electrode. For this purpose, the determination of Naratriptan which is a novel oral triptan (5-hydroxytryptamine receptor agonist) in migraine treat Read More

This review is focused on the use of the electrochemical techniques, voltammetry and polarography, as well as biosensors, for the study of drug stability. In addition, this review also details the study of drug metabolism by electrochemistry and mass spectrometry. This is used as a tool to mimic drug metabolism and because it is a purely instrumental method, may have advantages over, or be complementary to, the existi Read More

This review article has gathered different types of electrode modification with a brief introduction given to explain several phenomena occurring at chemically modified electrodes and the mechanism of detection, followed by some interesting applications of chemically modified electrodes (CMEs) in pharmaceutical analysis, emphasizing on the biosensors and CNT-based chemical sensors.

For many years mercury electrodes were commonly used in stripping voltammetry for determination of organic compounds, owing to their high sensitivity, reproducibility and renewability. However, because of the toxicity of mercury, alternative (less toxic) electrode materials are searched. The review describes recent results regarding adsorptive stripping voltammetric determination of trace concentration of biologically acti Read More

In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the Read More

Sibel A. Ozkan studied at Ankara University, from where she received her Pharmacy degree in 1985. She obtained her Master's (1988) and PhD (1994) degrees in the same university, Analytical Chemistry Department. She has become full professor 2003. She has been involved in several analytical chemistry projects related to electroanalytical chemistry and separation techniques on drug active compounds and DNA-Drug Read More