Skip to content
2000
Volume 13, Issue 8
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

A biomimetic sensor is proposed as a promising new analytical method for determination of captopril in different classes of samples. The sensor was prepared by modifying a carbon paste electrode with iron (II) phthalocyanine bis(pyridine) [FePc(dipy)] complex. Amperometric measurements in a batch analytical mode were first carried out in order to optimize the sensor response. An applied potential lower than 0.2 V vs Ag|AgCl in 0.1 mol L-1 of TRIS buffer at pH 8.0 provided the best response, with a linear range of 2.5 x 10-5 to 1.7 x 10-4 mol L-1. A detailed investigation of the selectivity of the sensor, employing seventeen other drugs, was also performed. Recovery studies were carried out using biological and environment samples in order to evaluate the sensor's potential for use with these sample classes. Finally, the performance of the biomimetic sensor was optimized in a flow injection (FIA) system using a wall jet electrochemical cell. Under optimized flow conditions, a broad linear response range, from 5.0 x 10-4 to 2.5 x 10-2 mol L-1, was obtained for captopril, with a sensitivity of 210 ± 1 μA L mol-1.

Loading

Article metrics loading...

/content/journals/cchts/10.2174/138620710791920392
2010-09-01
2025-06-27
Loading full text...

Full text loading...

/content/journals/cchts/10.2174/138620710791920392
Loading

  • Article Type:
    Research Article
Keyword(s): biomimetic sensor; captopril; FIA analysis; Iron phthalocyanine
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test