Current Bioinformatics - Volume 20, Issue 2, 2025

Peptidomics is the study of total peptides that describe the functions, structures, and interactions of peptides within living organisms. It comprises bioactive peptides derived naturally or synthetically designed that exhibit various therapeutic properties against microbial infections, cancer progression, inflammation, etc. With the current state of the art, Bioinformatics tools and techniques help analyse large peptidomics dat Read More

Recent evidence demonstrated the fundamental role of miRNAs as disease biomarkers and their role in disease progression and pathology. Identifying disease related miRNAs using computational approaches has become one of the trending topics in health informatics. Many biological databases and online tools were developed for uncovering novel disease-related miRNAs. Hence, a brief overview regarding the disease Read More

BackgroundOne of the most prevalent epigenetic alterations in all three kingdoms of life is 5mC, which plays a part in a wide range of biological functions. Although in-vitro techniques are more effective in detecting epigenetic alterations, they are time and cost-intensive. Artificial intelligence-based in silico approaches have been used to overcome these obstacles.AimThis study aimed to develop a ML-based predictor for the d Read More

IntroductionBreast Cancer (BC) is a significant cause of high mortality amongst women globally and probably will remain a disease posing challenges about its detectability. Advancements in medical imaging technology have improved the accuracy and efficiency of breast cancer classification. However, tumor features' complexity and imaging data variability still pose challenges.MethodsThis study proposes the En Read More

BackgroundCircular RNAs (circRNAs) play important regulatory roles in the progression of gastric cancer (GC), but the exact mechanisms governing their regulation remain incompletely understood. Prior studies typically used back-spliced junctions (BSJs) to represent a range of circRNA isoforms, overlooking the prevalence of alternative splicing (AS) events within circRNAs, which could lead to unreliable or even incorrect conclusio Read More

BackgroundCleft lip and palate are two of the most common craniofacial congenital malformations in humans. It influences tens of millions of patients worldwide. The hazards of this disease are multifaceted, extending beyond the obvious facial malformation to encompass physiological functions, oral health, psychological well-being, and social aspects.ObjectiveThe primary objective of our study is to demonstrate the im Read More