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Volume 20, Issue 2
  • ISSN: 1574-8936
  • E-ISSN: 2212-392X

Abstract

Background

Cleft lip and palate are two of the most common craniofacial congenital malformations in humans. It influences tens of millions of patients worldwide. The hazards of this disease are multifaceted, extending beyond the obvious facial malformation to encompass physiological functions, oral health, psychological well-being, and social aspects.

Objective

The primary objective of our study is to demonstrate the importance of imaging in detecting cleft lip and palate. By observing the morphological and structural abnormalities involving the lip and palate through imaging methods, this study aims to establish imaging as the primary diagnostic approach for this disease.

Methods

In this work, we proposed a novel model to analyze unilateral complete cleft lip and palate after velopharyngeal closure and non-left lip and palate patients from the Department of Stomatology of Xuzhou First People's Hospital, Conical Beam CT (CBCT) images in silicon. In order to demonstrate the generalization, the simulated dataset was constructed using the random disturbance factor, which is from the actual dataset. We extracted several raw features from CBCT images in detail. Then, we proposed a novel feature reconstruction method, including six types of reconstructed factors, to reconstruct the existing features. Then, the reconstructed features weretrained with machine learning algorithms. Finally, the testing and independent data model was utilized to analyze the performance of this work.

Results

By comparing different operator features, the min operator, max operator, average operator, and all operators can achieve good performances in both the testing set and the independent set.

Conclusion

With the different operator features, the majority of classification models, including Gradient Boosting, Hist Gradient Boosting, Multilayer Perceptron, lightGBM, and broadened learning, classification algorithms can get the well-performances in the selected reconstructed feature operators.

© 2025 Bentham Science Publishers
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2024-10-09
2025-04-21

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References

  1. Akarsu-GuvenB. KarakayaJ. OzgurF. AksuM. Upper airway features of unilateral cleft lip and palate patients in different growth stages.Angle Orthod.201989457558210.2319/022518‑155.130694706
     [Google Scholar]
  2. MosseyP.A. LittleJ. MungerR.G. DixonM.J. ShawW.C. Cleft lip and palate.Lancet200937497031773178510.1016/S0140‑6736(09)60695‑419747722
     [Google Scholar]
  3. Yatabe-IoshidaM.S. CamposL.D. YaeduR.Y. Trindade-SuedamI.K. Upper airway 3D changes of patients with cleft lip and palate after orthognathic surgery.Cleft Palate Craniofac. J.201956331432010.1177/105566561877862229846086
     [Google Scholar]
  4. VieiraA.R. Unraveling human cleft lip and palate research.J. Dent. Res.200887211912510.1177/15440591080870020218218836
     [Google Scholar]
  5. DixonM.J. MarazitaM.L. BeatyT.H. MurrayJ.C. Cleft lip and palate: Understanding genetic and environmental influences.Nat. Rev. Genet.201112316717810.1038/nrg293321331089
     [Google Scholar]
  6. RoyA.A. RtshiladzeM.A. StevensK. PhillipsJ. Orthognathic surgery for patients with cleft lip and palate.Clin. Plast. Surg.201946215717110.1016/j.cps.2018.11.00230851748
     [Google Scholar]
  7. YilmazH.N. ÖzbilenE.O. ÜstünT. The prevalence of cleft lip and palate patients: A single-center experience for 17 years.Turk. J. Orthod.201932313914410.5152/TurkJOrthod.2019.1809431565688
     [Google Scholar]
  8. PaiB.C.J. HungY.T. WangR.S.H. LoL.J. Outcome of patients with complete unilateral cleft lip and palate: 20-year follow-up of a treatment protocol.Plast. Reconstr. Surg.20191432359e367e10.1097/PRS.000000000000521630531628
     [Google Scholar]
  9. YatesD. AllareddyV. CaplinJ. YadavS. MarkiewiczM.R. An overview of timeline of interventions in the continuum of cleft lip and palate care.Oral Maxillofac. Surg. Clin. North Am.202032217718610.1016/j.coms.2020.01.00132115348
     [Google Scholar]
  10. SalgadoK.R. WendtA.R. Fernandes FagundesN.C. MaiaL.C. NormandoD. LeãoP.B. Early or delayed palatoplasty in complete unilateral cleft lip and palate patients? A systematic review of the effects on maxillary growth.J. Craniomaxillofac. Surg.201947111690169810.1016/j.jcms.2019.06.01731677987
     [Google Scholar]
  11. BittermannG.K.P. van EsR.J.J. de RuiterA.P. BittermannA.J.N. KooleR. RosenbergA.J.W.P. Retrospective analysis of clinical outcomes in bilateral cleft lip and palate patients after secondary alveolar bone grafting and premaxilla osteotomy, using a new dento-maxillary scoring system.J. Craniomaxillofac. Surg.202149211011710.1016/j.jcms.2020.12.00633357967
     [Google Scholar]
  12. KapadiaH. OlsonD. TseR. SusarlaS.M. Nasoalveolar molding for unilateral and bilateral cleft lip repair.Oral Maxillofac. Surg. Clin. North Am.202032219720410.1016/j.coms.2020.01.00832165093
     [Google Scholar]
  13. Swibel RosenthalL.H. WalshK. ThompsonD.M. Velopharyngeal incompetence: Role in paediatric swallowing deficits.Curr. Opin. Otolaryngol. Head Neck Surg.201826635636610.1097/MOO.000000000000049430300209
     [Google Scholar]
  14. Al-NamankanyA. AlhubaishiA. Effects of cleft lip and palate on children’s psychological health: A systematic review.J. Taibah Univ. Med. Sci.201813431131810.1016/j.jtumed.2018.04.00731435341
     [Google Scholar]
  15. KaraM. CalisM. KaraI. Kulak KayikciM.E. GunaydinR.O. OzgurF. Comparison of speech outcomes using type 2b intravelar veloplasty or furlow double-opposing Z plasty for soft palate repair of patients with unilateral cleft lip and palate.J. Craniomaxillofac. Surg.202149321522210.1016/j.jcms.2021.01.00333485752
     [Google Scholar]
  16. Al-FahdawiM.A. El-KassabyM.A. FaridM.M. El-FotouhM.A. Cone beam computed tomography analysis of oropharyngeal airway in preadolescent nonsyndromic bilateral and unilateral cleft lip and palate patients.Cleft Palate Craniofac. J.201855688389010.1597/15‑32227427930
     [Google Scholar]
  17. Hardin-JonesM. JonesD.L. DolezalR.C. Opinions of speech-language pathologists regarding speech management for children with cleft lip and palate.Cleft Palate Craniofac. J.2020571556410.1177/105566561985700031220929
     [Google Scholar]
  18. KimE. KimY.J. JiZ. KangJ.M. WiriantoM. PaudelK.R. SmithJ.A. OnoK. KimJ.A. Eckel-MahanK. ZhouX. LeeH.K. YooJ.Y. YooS.H. ChenZ. ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer.Cell Death Dis.202213437410.1038/s41419‑022‑04826‑535440077
     [Google Scholar]
  19. PotemraH.M.K. LinJ. BertrandA.A. De LeonF.S. AlfordJ.A. HuA.C. WilsonL. LeeJ.C. Long-term effect of multiple operations on psychosocial function in teenage cleft lip and palate patients.Plast. Reconstr. Surg.2020146161e68e10.1097/PRS.000000000000690532590656
     [Google Scholar]
  20. WorleyM.L. PatelK.G. KilpatrickL.A. Cleft lip and palate.Clin. Perinatol.201845466167810.1016/j.clp.2018.07.00630396411
     [Google Scholar]
  21. ZaluzecR.M. RodbyK.A. BradfordP.S. DanielsonK.K. PatelP.K. RosenbergJ. Delay in cleft lip and palate surgical repair: An institutional review on cleft health disparities in an urban population.J. Craniofac. Surg.20193082328233110.1097/SCS.000000000000574031306388
     [Google Scholar]
  22. JiZ. ZhaoW. LinH.K. ZhouX. Systematically understanding the immunity leading to CRPC progression.PLOS Comput. Biol.2019159e100734410.1371/journal.pcbi.100734431504033
     [Google Scholar]
  23. ReiserE. Andlin-SobockiA. ManiM. HolmströmM. Initial size of cleft does not correlate with size and function of nasal airway in adults with unilateral cleft lip and palate.J. Plast. Surg. Hand Surg.201145312913510.3109/2000656X.2011.57683921682609
     [Google Scholar]
  24. Mink van der MolenA.B. JanssenK. SpeckenT.F.J.M.C. StubenitskyB.M. The modified Honig velopharyngoplasty – A new technique to treat hypernasality by palatal lenghtening.J. Plast. Reconstr. Aesthet. Surg.200962564664910.1016/j.bjps.2007.12.02318249165
     [Google Scholar]
  25. ZhaoX. LiH. LyuS. ZhaiJ. JiZ. ZhangZ. ZhangX. LiuZ. WangH. XuJ. FanH. KouJ. LiL. LangR. HeQ. Single-cell transcriptomics reveals heterogeneous progression and EGFR activation in pancreatic adenosquamous carcinoma.Int. J. Biol. Sci.202117102590260510.7150/ijbs.5888634326696
     [Google Scholar]
  26. RoseE. StaatsR. ThissenU. OttenJ.E. SchmelzeisenR. JonasI. Sleep-related obstructive disordered breathing in cleft palate patients after palatoplasty.Plast. Reconstr. Surg.2002110239239610.1097/00006534‑200208000‑0000212142649
     [Google Scholar]
  27. O’connorB.P. SPSS and SAS programs for determining the number of components using parallel analysis and Velicer’s MAP test.Behav. Res. Methods Instrum. Comput.200032339640210.3758/BF0320080711029811
     [Google Scholar]
  28. ChangC.S. WallaceC.G. HsiaoY.C. HsiehY.J. WangY.C. ChenN.H. LiaoY.F. LiouE.J.W. ChenP.K.T. ChenJ.P. ChenY.R. Airway changes after cleft orthognathic surgery evaluated by three-dimensional computed tomography and overnight polysomnographic study.Sci. Rep.2017711226010.1038/s41598‑017‑12251‑428947808
     [Google Scholar]
  29. BaoW. CuiQ. ChenB. YangB. Phage_UniR_LGBM: Phage virion proteins classification with UniRep features and LightGBM model.Comput. Math. Methods Med.2022202211810.1155/2022/947068335465015
     [Google Scholar]
  30. SobralD.S. FallerG.J. CollaresM.V.M. Respiratory polysomnographic findings in patients treated primarily for unilateral cleft lip and palate.Cleft Palate Craniofac. J.201855228729110.1177/105566561772653829351040
     [Google Scholar]
  31. SilvestreJ. TahiriY. PaligaJ.T. TaylorJ.A. Screening for obstructive sleep apnea in children with syndromic cleft lip and/or palate.J. Plast. Reconstr. Aesthet. Surg.201467111475148010.1016/j.bjps.2014.07.02625130290
     [Google Scholar]
  32. ZimmermanJ.N. VoraS.R. PliskaB.T. Reliability of upper airway assessment using CBCT.Eur. J. Orthod.201941110110810.1093/ejo/cjy05830184085
     [Google Scholar]
  33. GurgelM.L. JuniorC.C. CevidanesL.H.S. de Barros SilvaP.G. CarvalhoF.S.R. KuritaL.M. CunhaT.C.A. Dal FabbroC. CostaF.W.G. Methodological parameters for upper airway assessment by cone-beam computed tomography in adults with obstructive sleep apnea: A systematic review of the literature and meta-analysis.Sleep Breath.202327113010.1007/s11325‑022‑02582‑635190957
     [Google Scholar]
  34. AprianiA. PrimartiR.S. KasimA. OscandarF. Assessment of nasopharynx area and level of severity posterior crossbite on children with cleft lips and palate post-palatoplasty.Padjadjaran J Dent202032214214810.24198/pjd.vol32no2.17951
     [Google Scholar]
  35. AbdelkarimA.Z. KhalifaA.R. MaligroJ. WongC. LozanoffN. FarrellM. FarrellJ. LozanoffS. Automated identification of anatomical anomalies in the hyoid region of cleft lip and palate patients.Trans Res Anat20212310010310.1016/j.tria.2020.100103
     [Google Scholar]
  36. AstaniS.A. YilmazH.N. NevzatogluS. DemirkayaA.A. AcarZ.A. Evaluation of airway volume in cleft lip and palate following nasoalveolar molding.J. Craniofac. Surg.20182982143214710.1097/SCS.000000000000468129944553
     [Google Scholar]
  37. ErtaşÜ. AtaolM. Evaluation of nasal airway volume of operated unilateral cleft lip and palate patients compared with skeletal Class III individuals.Cleft Palate Craniofac. J.2019561152010.1177/105566561877402429738291
     [Google Scholar]
  38. MehtaS. BajajK. NagpalE. SharmaS. MittalK. JharwalV. Assessment of the relationship between adenoid tissue and mandibular prognathism: A cephalometric study.J Mahatma Gandhi Univ Med Sci Technol20183251
     [Google Scholar]
  39. AbualigahL. SheikhanA. IkotunA.M. ZitarR.A. AlsoudA.R. Al-ShourbajiI. HussienA.G. JiaH. Particle swarm optimization algorithm: Review and applications. In: Metaheuristic Optimization Algorithms2024114
     [Google Scholar]
  40. Al-ShourbajiI. KachareP. FadlelseedS. JabbariA. HussienA.G. Al-SaqqarF. AbualigahL. AlameenA. Artificial ecosystem-based optimization with dwarf mongoose optimization for feature selection and global optimization problems.Int J Comput Intell Syst202316110210.1007/s44196‑023‑00279‑6
     [Google Scholar]
  41. NassehI. Al-RawiW. Cone beam computed tomography.Dent. Clin. North Am.201862336139110.1016/j.cden.2018.03.00229903556
     [Google Scholar]
  42. BaoW. YangB. Protein acetylation sites with complex-valued polynomial model.Front. Comput. Sci.202418318390410.1007/s11704‑023‑2640‑9
     [Google Scholar]
/content/journals/cbio/10.2174/0115748936330499240909082529
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CLPr_in_ML: Cleft Lip and Palate Reconstructed Features with Machine Learning
Curr Bioinform 20, 179 (2025); https://doi.org/10.2174/0115748936330499240909082529
/content/journals/cbio/10.2174/0115748936330499240909082529
/content/journals/cbio/10.2174/0115748936330499240909082529
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  • Article Type:     Research Article
Keyword(s): classification; Cleft lip; conical beam CT; craniofacial congenital; machine learning; palate; random disturbance factor; reconstructed features

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