Current Bioactive Compounds - Online First

Background Paracetamol overdose can lead to severe liver damage due to the formation of toxic metabolites. Casimiora edulis, rich in polyphenols and flavonoids, and silymarin, a known liver protectant, may help mitigate this damage. Objective This study aims to characterize the main phytoconstituents of Casimiora edulis leaves and evaluate their hepatoprotective activity. Methods Leaves of Casimiora edulis were extr Read More

A complicated neural developmental condition, autism spectrum disorder (ASD) is marked by difficulties with social interaction, communication, and repetitive behaviours. There is increasing interest in complementary and alternative medicines, including medicinal plants, to treat the symptoms of ASD as incidence rates rise globally. This thorough analysis looks at the available data supporting a range of plant-based ASD control Read More

Introduction This study explores the therapeutic potential of Bixa orellana (B. orellana), focusing on its bioactive compounds and antioxidant effects. Phytochemical analysis combined with network pharmacology was employed to investigate its multi-targeted therapeutic potential against oxidative stress. Methods The antioxidant activity of B. orellana flower extract was determined using DPPH assays. High-performance thi Read More

Epilepsy, a prevalent neurological disorder, affects approximately 1% of the Indian population, presenting a significant challenge in clinical management. Noninvasive treatment options are actively being explored, with nose-to-brain drug delivery emerging as a promising approach for effective epilepsy control. This comprehensive review delves into the potential of intranasal nanotherapy, focusing on its applicability in Read More

Diabetes mellitus is a chronic metabolic disorder which occurs due to deficiency of insulin or resistance to insulin receptor. There are naturally occurring compounds found in various plants, foods, and herbs that have potent anti-diabetic properties. They help to control blood sugar levels by increasing insulin sensitivity and stimulating glucose absorption in cells. Diosmin, a flavonoid glycoside found primarily in citrus fruits, has Read More

Background The use of plant extracts in the biosynthesis of nanoparticles has garnered attention in recent years due to the rapid, ecological, and economical production protocol. The current study aimed to biosynthesize silver nanoparticles (AgNPs) of Hypochaeris radicata L. extract. Methods These nanoparticles were characterized by UV-Vis, Fourier Transform Infrared Spectroscopy (FTIR), and X-Ray Diffraction (XRD) to deter Read More

Cancer is a highly fatal disease that is typified by aberrant cells proliferating out of control. The properties of acquired cells, including as genomic instability and mutations, cellular death evasion, and proliferative signaling sustenance, are evidenced by the hallmarks of cancer and contribute to the establishment of malignant tumors. A protein called poly(ADP-ribose) polymerase-1 (PARP1) is essential for both cell survival and DN Read More

The traditional use of medicinal plants holds a wealth of ancient wisdom that inspires modern research. Piper betle, generally recognized as betel leaf, is valued in traditional medicine systems across various cultures for its diverse health benefits. The betel leaves have several significant uses as antioxidant, anti-inflammatory, and antiapoptotic activity which help in neuroprotection. Many phytochemicals are present in the bete Read More

Background Inflammation, a crucial defense mechanism of the immune system, seeks to safeguard and restore tissue equilibrium in response to tissue damage or infection by pathogens. Key indicators of inflammation include redness, discomfort, swelling, warmth, and impaired function. However, unmanaged inflammation can lead to serious health issues. Objective The aim of this research work is to perform docking stu Read More

This article offers in-depth information on the pharmacological effects, historical background, and chemical makeup of capsaicin, the primary ingredient in chili peppers. Capsaicin was first discovered in Mexico about 5000 BC, and it has since changed from being a culinary spice to a substance with substantial medicinal potential. It covers the chemical characteristics of capsaicin, how it activates the sympathetic nerv Read More

Background Bioactive compounds were isolated, characterized, but their efficacy, potency and mechanism of action to treat/prevent several diseases yet to defined. The present review provides the insight on the activity of nature derived bioactive compounds therapeutic potential against communicable and non-communicable disease by using in silico approaches such as structure-based virtual screening, ligand-based virt Read More

The impact of naturally occurring flavonoids on human health and illnesses is crucial, as they are closely linked to dietary components and human health. Flavonoids may be able to shield people against disease in both in vitro and in vivo research settings. The flavonoid chrysin has demonstrated several intriguing pharmacological properties, including immune modulation, anti-cancer, anti-diabetic, antidepressant, a Read More

Background Tetrazole-based compounds are of significant interest due to their potential pharmacological applications. The current study focuses on the synthesis and analysis of such a compound. Objective This research aims to synthesize the title compound N-(3-methyl-1-phenyl-2-(1H-tetrazol-1-yl) butyl) acetamide, analyze its crystal structure, perform computational studies, and evaluate its potential pharmacological activities Read More

Withania somnifera (L.) Dunal (W. somnifera) is an herb commonly known by its English name Winter Cherry, and Ashwagandha in Hindi. It has been used as a traditional Rasayana herb for a long time. It is a rich reservoir of bioactive compounds known as withanolides, namely, withaferin-A and withanolide-D. Its current research covers many aspects of human health, which include anti-stress, anti-tumor, 9immuno-modulato Read More

Bakuchiol, a meroterpene natural product found in various plants, exhibits diverse biological activities, notably anticancer properties. Researchers have synthesized numerous analogs targeting different positions, such as alcoholic OH, ethenyl, and isopropylidene groups within bakuchiol, aiming to enlighten potent therapeutic agents with enhanced pharmaceutical characteristics. The review aims to focus on the extensive potenti Read More

Aim Present study deals to access the antidepressant activity of Etlingera elatior leaves extract in rodent. Background Etlingera elatior is a species of herbaceous perennial plant in the family Zingiberaceae; native to Indonesia, Thailand, Malaysia and New Guinea. Depression is one of the most common mental disorders affecting humans, pathological basis of which is not fully understood. The current antidepressant drugs have Read More

Background Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. To develop more effective anti-CRC drugs, this research evaluated the impact of synthesized liposomal daunorubicin on HTC116 colon cancer cell line. Methods Liposomal daunorubicin (LDNR) was synthesized by the thin layer hydration method and size was determined by dynamic light diffraction (DLS). MTT assay was u Read More