Current Bioactive Compounds - Volume 12, Issue 4, 2016

Background: The most important investigations since the first publication on opiorphin, in 2006, are summarized in this review. Opiorphin is a human endogenous pentapeptide (Gln-Arg-Phe-Ser-Arg) which inhibits both the Neutral EndoPeptidase (NEP) and aminopeptidase N (AP-N), protecting enkephalins from degradation by these ectopeptidases, thus activating endogenous enkephalin-related opioid pathways. Obje Read More

Background: This review elaborates the updated synthetic approaches of a known group of dihydropyrimidinones/thiones and their reactions. Also an updated literature overview on the biologically active dihydropyrimidinone analogs is provided. Methods: The data written in this review was taken from the peer reviewed national and international literature and a deductive qualitative content analysis methodology was used to Read More

An HPLC-coulometric electrode array detection (CEAD) based method for the determination of protocatechuic acid, chlorogenic acid, rutin (quercetin-3-O-rutinoside), nicotiflorin (kaempferol-3-Orutinoside) and quercetin in elderberry juice was developed. Sample work up for the determination of phenolic acids included solid phase extraction (SPE). For the analysis of flavonoids, simple dilution and centrifugation st Read More

Functional beverage from fermented beet-root (Beta vulgaris) using a coculture of Lactobacillus acidophilus and Lactobacillus plantarum was investigated. The juice was fermented for 24 and 48 h and the samples were analyzed for their physio-chemical changes, cell viability and preservation efficiency. A pH drop was observed for four days in both 24 and 48 h fermented samples, after which the pH increased till t Read More

Gymnema sylvestre R.Br. is an important medicinal plant traditionally used as an antidiabetic agent. Excessive use of the plant has resulted in its mass depletion from the natural habitat. In the present work, flavonoids were identified from the plant parts and callus culture. Different colored callus was obtained using various concentrations of hormones. The flavonoids (quercetin and kaempferol) were identified using chromat Read More

Strawberry fruits have a high antioxidant capacity that it is associated with the content of polyphenolic compounds and, specifically, anthocyanins. A potential source of these compounds is the strawberry pulp processing industry, which produces a large quantity of agro-industrial waste in its production chain. The anthocyanins were extracted using ethanol acidified with hydrochloric, tartaric, citric, lactic, and phosphoric acids, Read More

Background: Searching for well-organized organic synthesis approach that can be authenticated for the rapid generation of complex organic molecules from simple and readily accessible starting materials are in a vogue in the recent epochs. Recently, the developments of green protocols which are environmentally benign and without pollution have received substantial levels of consideration, owing to the increasing tenden Read More

Background: In the expanding field of anticancer drugs, HDAC inhibitors are playing an increasingly important role. To date, four/five HDAC inhibitors have been approved by FDA. All these compounds fit the widely accepted HDAC inhibitors pharmacophore model characterized by a cap group, a linker chain and a zinc binding group (ZBG), able to bind the Zn2+ ion in a pocket of the HDAC active site. Romidepsin, a natural Read More

Background: A quantitative and reliable relationship between in vitro drug release and in vivo absorption is desirable for rational development and optimization of extended release (ER) dosage forms. This article describes the development and validation of an in vitro - in vivo correlation (IVIVC) for ER tablets of Lamotrigine. Methods: Two prototype extended release tablets of lamotrigine were formulated. Predictive in vitro dissol Read More

Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, hemorrhoids and diarrhea. Methods: In this study, antibacterial, antioxidant, toxicity, acetylcholinesterase and μ- glucosidase inhibitory activities of several extracts of S. santolinifolia were evaluated. T Read More