Current Bioactive Compounds - Volume 12, Issue 2, 2016

The aim of the current research work was to formulate, optimize and assess micronized Silver sulfadiazine (mSSD) topical gel containing Aloe vera gel (AV-gel) for the healing effect on second degree burn wounds induced in Albino Wistar rats. Concentration of Carbopol 940, gelling agent, was selected based on observation of optimum spreadability and consistency. Second-degree burn wounds were developed on the posterior Read More

The principle of this method was to screen the pharmacological activity of ten prepared polyphyto formulations by using highthroughput screening method for their antihyperlipidemic activity. The study was performed in three stages using single animal, two animals and three animals in a group. The data produced with single animal is compared with the average data shown by two and three experimental animals and furt Read More

Formulations were prepared containing Bergenia ligulata, Didymocarpus pedicellata, Dolichos biflorus, Boerhaavia diffusa, Crataeva nurvala and Ocimum sanctum in different ratios and coded as F1, F2 and F3. In vivo urolithiatic activities of the prepared formulations (i.e. F1:20, F1:40, F1:60, F2:20, F2:40, F2:60, F3:20, F3:40 and F3:60) were performed in rats using ethylene glycol induced urolithiasis model. It was observed tha Read More

Secoiridoid glycosides comprise a group of important phyto-components from members of Gentianaceae. They possess significant antipyretic, anti-inflammatory, antidiabetic and hypolipedimic activities. This study is designed for the development of an effective method for extraction of a bioactive secoiridoid glycoside namely swertiamarin, from the whole plant of Enicostema littorale Blume. The conditions for its ultrasoun Read More

A highly sensitive ultra-high pressure liquid chromatography (UHPLC-MS/MS) method for estimation of paclitaxel in rat plasma has been validated. The chromatographic separation was achieved using isocratic mobile phase, consisting of acetonitrile–2mM ammonium acetate (70:30 v/v; 0.25 mL min-1). Docetaxel was used as an internal standard and tert-butyl methyl ether (TBME) as organic solvent for the liquid-liquid extraction. Read More

Over the years, natural products have the dominant status in the discovery of new effective therapeutic agents, but from 1990's, onward pharma-industry showed paradigm shift towards synthetic drugs. However, the strategic shift of the research and development (R) of major pharmaceutical organizations away from synthetic agents that interfere to interact with single targets for therapeutic effect reverse to the discovery of Read More

α-phellandrene antiedematogenic effect (α-Phel) was evaluated in carrageenan, histamine, prostaglandin and substance P induced paw edema and croton oil, TPA and arachidonic acid induced ear edemain mice. Experimental protocols were approved by Ethical Committee for Animal Experimentation (CEEA/UFPI, Protocol Nº 010/2011). α-Phel (100 and 200 mg.kg-1, p.o.) reduced carrageenan and prostaglandina (40.9 Read More

In this study, anti-inflammatory, wound healing and anti-ulcerogenic properties of chitosan were evaluated ‘in vivo’ using wistar rats and swiss adult mice and the anti-proliferative activity was tested ‘in vitro’. The tested chitosans displayed no anti-proliferative or anti-inflammatory properties. The cytotoxic activity of chitosan was found to be non-existent towards eight tumoral cell lines and no significant differences were found in t Read More

Heliotropium ellipticum is an herbaceous annual plant; and its resinous exudate is known for various types of therapeutic effects. The recent study was carried out to investigate the presence of flavonoids and their screening for anti-inflammatory and antimicrobial activities. The carrageenan and CFA-induced paw oedema models were adopted for the assessment of anti-inflammatory activity of dichloromethane fraction and is Read More