Current Bioactive Compounds - Volume 12, Issue 1, 2016

This review is a brief but comprehensive overview on the multi-target profile of oleocanthal, an extra-virgin olive oil (EVOO) phenol corresponding to the (-)-decarboxymethylligstroside aglycone, speculating about its potential in the prevention and/or treatment of various diseases, such as neurodegeneration, inflammation and cancer.

The effect of a prickly pear peel extract on cholesterol excretion and plasma and hepatic cholesterol levels in hamsters with induced hypercholesterolemia was investigated. Female and male hamsters were fed for 5 weeks with experimental diets: NC, normal cholesterol diet; HC, hypocholesterolemic diet; HCOp, HC with prickly pear peel extract and HCPh, HC with phytosterols. Male and females hamsters fed HCO Read More

Chemical stability of anthocyanins in aqueous solutions has been one of the major drawbacks for health applications. Complexation of anthocyanins formed by aqueous extracts of dried cobs of Zea mays L. ceritina Kulesh. (CC) and blue petals of Clitoria ternatea L. (CT) was challenged by thermal accelerated stability testing of total anthocyanins by pH differential method, with in vitro antiinflammatory and anti-candida scr Read More

Objective: The current study was planned to analyze the effects of the aqueous extract of Cynodon dactylon (AECD) in a rat model of Streptozotocin (STZ) induced-diabetes and nitric oxide (NO)-deficient hypertension. Materials and Methods: Diabetes was induced by a single dose of STZ (55 mg/kg, i.p., in 0.1M citrate buffer, pH 4.5). To induce the NO-deficient hypertension, rats were treated with the Nitric Oxide sy Read More

Medicinal plants are rich sources for drug discovery. Occurrence of Diabetes mellitus is increasing because of changes in human lifestyle. So, design or discovery of new and more effective and safer drugs is needed. At the present study, the enzyme inhibitory effects of methanol extracts of selected Lamiaceae species (Salvia syriaca L., Teucrium polium L., Phlomis olivieri Benth., Nepeta ispahanica Boiss., Scutellaria tomen Read More

This paper describes a study of the content of total phenolic contents, the antioxidant capacity and the cyclic voltammetry of Zilla macroptera aqueous extract. The results demonstrate that the content of total phenolics was 89±2.46 μg of Gallic acid equivalence per 1 mg of extract and the content of total flavonoids was 12.99±0.67 μg of Quercetin equivalency per 1 mg of extract. Four methods ‘‘in vitro’’ were used to evalu Read More

Background: Andrographolide, a labdone diterpene extracted from Andrographis paniculata possesses various medicinal properties and has been used in treatment of number of chronic diseases, in humans. Objectives: Evaluation of the effects of andrographolide on COX-2 enzyme (in silico and in vitro studies). Materials and Methods: The interactions of andrographolide with COX-2 protein were evaluated (in silico) by molecu Read More

This study investigates the chemical composition and the biological activities of the essential oils of Vitex agnus-castus. The essential oils from the dry leaves, flowers and seeds of Vitex agnus- castus L., were obtained by hydro-distillation, and their volatile constituents were identified by GC/MS. Antioxidant activity of the samples was determined by DPPH method. Antifungal and antibacterial activities were tested using three fung Read More