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Volume 21, Issue 1
  • ISSN: 1573-4072
  • E-ISSN: 1875-6646

Abstract

Environmental pollutants pose a serious risk to human health and are involved in the emergence of many diseases and disorders. In recent years, the research for efficient defence against these pollutants has focused much interest. Natural flavonoid apigenin in various fruits and vegetables has shown great defence against environmental toxins. This review aims to summarize the current knowledge regarding the protective effect of apigenin against environmental pollutants and its underlying mechanisms. The study starts by summarizing the main industrial chemicals, environmental pollutants, water contaminants, and the health hazards they provide. The article discusses apigenin's bioactive attributes and focuses on its anti-inflammatory, detoxifying, and antioxidant activities. Previous studies have shown that apigenin supplementation can reduce oxidative stress, inflammation, DNA damage, and organ toxicity from pollutants. The molecular processes behind apigenin's anti-inflammatory effects are explored, including its interactions with important signaling networks. Additional research is required to assess its ideal dosage, bioavailability, and potential interactions with other drugs. Moreover, more human studies are required to evaluate the long-term advantages and safety of apigenin supplementation as a defence against the harmful health consequences of environmental contaminants.

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2024-03-05
2025-01-17

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The Role of Apigenin in Alleviating the Impact of Environmental Pollutants
Curr. Bioact. Compd. 21, E050324227673 (2025); https://doi.org/10.2174/0115734072296125240221061200
/content/journals/cbc/10.2174/0115734072296125240221061200
/content/journals/cbc/10.2174/0115734072296125240221061200
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  • Article Type:     Review Article
Keyword(s): Apigenin; detoxification; environmental pollutants; inflammation; oxidative stress; protection

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