Current Analytical Chemistry - Volume 14, Issue 6, 2018

Background: Iodide (I-) is a vital micronutrient and its essential roles have been approved in a number of neurological activities. Therefore, there is a growing interest in developing reliable sensitive quantitative methodologies for the determination of the amount of I- in edible salt samples. Methods: First, 2heDTC was synthesized by the mixing of equivalent amounts of pure C2H7NO and CS2 in the presence of NH4OH under Read More

Background: Manganese, Mn, is an essential element that is present in steels, and determines steel's mechanical properties. Traditionally, atomic absorption and X-ray photoelectron spectroscopic methods were used for Mn analysis and complicated instrument operations, sometimes of high cost, are associated, and spectrophotometry/colorimetry is another tool for Mn analysis with simple operations. Nowadays, smartphone Read More

Background: This study was designed to develop a reliable method for simultaneous quantitation of Citalopram (CIT) and its main active metabolite, Desmethylcitalopram (DCIT), in saliva of patients undergoing treatment with CIT. Methods: To compare two procedures of saliva purification, Solid-Phase (SPE) and Liquid-Liquid (LLE) extractions, saliva samples obtained from healthy volunteers were spiked with adequate quantities o Read More

Background: Dietary supplements are products that aim to complement the diet of healthy individuals, and may show nutritional, metabolic and physiological effects. The consumption of dietary supplements is increasing every year all over the world and has been accompanied by an increased frequency of adulteration of these products with synthetic pharmaceuticals. Analytical methods that allow testing for the pres Read More

Method: A modified quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction method followed by a simple isocratic reversed-phase high-performance liquid chromatography was applied to the simultaneous analysis of Sodium Benzoate (SB) and Potassium Sorbate (PS) preservatives in some dairy products was developed. Results: At first, comparison of the obtained results using original unbuffered and Read More

Background: Substance P and CGRP are neuropeptides that belong to the thachykinin and calcitonin family, respectively. They play an important role in neuropathic pain development and regulation. Methods: In this study, simultaneous analysis of Substance P and CGRP in rat brainstem tissue was conducted by using LC-ESI-MS/MS method. A gradient mobile phase was used with a Zorbax C8 150x2.1 mm, a particle size of 3.5 μ Read More

Background: Excessive active oxygen will suppress the antioxidant defense system, resulting in a series of negative effects. Antioxidant substances in the diet can protect important biological molecules by mitigating the harm caused by oxidative stress and reducing the occurrence of chronic diseases related to aging. Therefore, simple, reliable and rapid detection methods for screening potential antioxidants in the diet have b Read More

Background: Overuse of antibiotics has become a serious ecological problem worldwide. It is necessary to monitor and control the pollution of antibiotics. Kanamycin is a representative antibiotic and has widely been used to treat a wide variety of infections. Although different methods have been established for kanamycin detection, it is still of great significance to develop new sensing approach to kanamycin monitoring. Met Read More

Background: In order to combat neurocysticercosis, effective and novel Fixed Dose Drug Combinations (FDC) of combination dosage regimens have been always under trial; with Albendazole (ABZ) and Praziquantel (PZQ) combination being one of them. Such outcome is basically dependent on the pharmacokinetic profiling of their metabolites such as Albendazole Sulphoxide (ABZSO, active), Albendazole Sulphone (ABZSO2, inac Read More

Background: PBDEs consist of synthetic chemicals frequently employed to help reducing or avoiding flame spread in a fire. As reactive flame retardants, they are covalently bound to the polymeric matrix of various domestic products. These compounds have drawn attention due to their large-scale production and use, and numerous papers have reported their presence as well as persistence in water, soil, sediment and a Read More

Background: Tricyclic Antidepressants (TCAs) can be used for the treatment of depression, psychiatric disorders and insomnia. They are used extensively in all the countries especially in the developed countries and therefore, can enter the aquatic environment mainly through the human excretion. These drugs cannot be completely removed or degraded during the sewage treatment process and their concentrations in th Read More

Background: Regorafenib is a multikinase inhibitor, indicated for the treatment of metastatic colorectal cancer and locally advanced, unresectable or metastatic gastrointestinal stromal tumor. Objective: A simple and fast, validated bioanalytical method is required for pre-clinical or clinical safety and efficacy investigations and possible pharmacokinetic interaction of regorafenib. Method: Regorafenib and sorafenib were elut Read More

Background: Among different metal oxides, ferrites play an important role in many fields such as transformers, gas sensors and energy storage and conversion. The magnetic properties of Coferrites are due to the cation distribution among octahedral and tetrahedral sites. Such distribution can be controlled by the preparation method which in its turn depends on the particle size and morphology. Among different synthesis te Read More

Background: The feasibility of applying methods or the extraction of Allium cepa essential oils using solvent-free microwave extraction (SFME) has been compared to hydro-distillation (HD) process. Parameters of extraction were investigated using a rational design of experiment screening. Objective: To screen the important factors that may influence the quantity and/or quality of the extracts derived from Allium cepa. Meth Read More