Current Analytical Chemistry - Volume 14, Issue 2, 2018

Background: Atorvastatin calcium belongs to a group of drugs known as statins. It is commonly used to treat a heart disease, so it is used to lower or reduce the fats and bad cholesterol in blood. It has also been used to increase the good cholesterol in blood. Atorvastatin calcium content is commercially known as "Lipitor" tablet. It is available in local pharmacies at different concentrations; 10, 20 and 40mg. Atorvastatin calc Read More

Background: Atorvastatin (ATOR) is an antihyperlipoproteinemic drug, (3R, 5R)-7-[2-(4- fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid (Fig. 1a). It is used for the treatment of dyslipidemia and for prevention of different cardiovascular disorders. Methods: A simple and sensitive analytical procedure has been developed, optimized and validated by square wave voltamme Read More

Background: Recently, two-phase flow solvent extraction has been emerged as a promising method for the extraction of radionuclides because it enables minimized radiation exposure and little waste emission. In the field, the coupling of microfluidics-based solvent extraction and stripping with ICP-MS is expected because the combination enables highly sensitive and selective analysis. The previous works have successfully coupl Read More

Objective: This study uses a novel complexing agent of 2-(2'-benzothiazolylazo)-6- aminophenol impregnated adsorbent multi-walled carbon nanotubes to enrich and separate trace levels of Cd (II), Cu (II), Co (II), Ni (II) and Pb (II) from various samples of food and water collected in Saudi Arabia. Method: Identification of the analyte ions was confirmed by flame atomic absorption spectrometry. The analytical parameters an Read More

Background: Reports on the mycotoxin ochratoxin A occurrence in wine and beer indicate that this is a worldwide problem due to the widespread consumption of these beverages. Objective: The existing solid phase extraction methods for the ochratoxin A are usually used in the form of microcolumns, which are generally driven by pumps and take a long time to finish sample pretreatment. It is highly desirable to develop Read More

Background: The vital importance of trace metal analysis in environmental water samples is widely recognised. In many cases, due to the low levels of trace metals in water samples and the high complexity of the matrixes (i.e. seawater), direct determination of trace metals is not always possible. Atomic absorption spectroscopy (AAS) is a low cost, simple and available technique in many laboratories, but it usually shows s Read More

Background: Carbamazepine (CBZ) has complex pharmacokinetic properties leading to fluctuation in plasma level, which requires routine therapeutic drug monitoring (TDM) to ensure its efficacy and prevent adverse effects. The objective of this study is directed towards developing and validating a simple, precise, rapid and highly sensitive liquid chromatography-mass spectrometry (LC/MS) technique for measuring CBZ Read More

Background: Phosphate and silicate are very important in a variety of compounds such as mineral resources, underground water, detergents and cleaners. Phosphate and silicate in water positively influence the metabolism of plants and animals. They have led to an environmental problem. This problem can have serious consequences because phosphate and silicate are widely utilized in water softening, surfactants and a lar Read More

Background: Electrochemical DNA sensor is a convenient and sensitive method for the detection of target ssDNA sequence. The developments of nanomaterials modified electrodes provide more opportunity for the enhancement of the analytical performances. Objective: The aim of this paper is to construct a new electrochemical DNA sensor for the detection of Staphylococcus aureus nuc gene sequence with a chitosan-graph Read More

Background: The acid extraction and enzymatic hydrolysis of starch followed by ion chromatography analysis are the tobacco industry standard methods in China which are very timeconsuming, troublesome, and moreover, there has no structure information of starch. This paper aims to develop an overall method for rapid extraction and simultaneous analysis of the content and structure of starch from flue-cured tobacc Read More

Background: The majority of non-small cell lung cancer (NSCLC) creates advances in the knowledge of tumor biology and mechanisms of oncogenesis have granted the singling out of several molecular targets for NSCLC treatment. Bevacizumab is an anti-growth factor vascular endothelial growth factor (VEGF) monoclonal antibody, it is the antiangiogenic agent at the most advanced stage of development in the Read More