Current Analytical Chemistry - Volume 13, Issue 6, 2017

Objective: A simple, economical and rapid RP-HPLC method with PDA detector was developed and validated for the simultaneous determination of simvastatin and caffeine in pure form, in formulation and the method is applied to monitor these drugs in mice plasma. Caffeine containing food and drugs commonly co-administered with statins, there is also a possibility of the caffeine-statins combination as anti-influenza formula Read More

Background: Cobalt is one of the most important essential trace metals of human nutrition. Low doses of cobalt are needed for many humans and animals to stay healthy. Cobalamine (named vitamin B12) is a cobalt-containing essential vitamin. The direct detection of metal ions in various matrices by AAS may be difficult due to matrix interferences and extremely low levels of metal ions. Thus, a preconcentration and separ Read More

Background: A new modified electrode based on the poly(chromotropic acid) (4,5-dihydroxynaphthalene- 2,7-disulfonic acid) film was developed by electrochemical polymerization to explore its voltammetric behavior. The electrochemical synthesis of poly(chromotropic acid) was accomplished by applying an aqueous solution of sodium hydroxide as a supporting electrolyte (0.1 M). The electrochemical behaviors of bisphenol A ( Read More

Background: Fusel oil is a mixture of higher alcohols produced as a minor fraction of the fermentation-distillation process in sugar and ethanol industries. It can be used as a fixating agent in cosmetics products, as solvent in the food industry, or recycled as fertilizer. Considering the effects of toxic elements contamination on the quality and safety of these products, and on the environment, an efficient method for elemental Read More

Background: In biosensors, enzymes play a crucial role in the analyte detection. However, enzyme based sensors suffer from reproducibility, tiresome immobilisation processes, high cost, and loss of enzymatic activity. In order to solve these problems, non-enzymatic detection of analytes is interesting due to the drawbacks described as regards enzymatic detection. Non-enzymatic sensor was presented in this study. Metho Read More

Background: Enzyme-linked immunosorbent assay (ELISA) array, a multiplex ELISA format, has significant advantages in comparison with classic ELISA technology, however, caution is necessary when fabricating an ELISA array for a research. Spotting buffer plays a key role in the performance of glass slide based protein microarray, however, such a buffer effect on polystyrene micro-plate has not been studied in d Read More

Background: The ability to accurately assess antioxidant activity would help monitor oxidation- reduction balance and the occurrence and progress of disease. Thus, the purpose of this study is to establish a combination serum assay for determination of total antioxidant capacity. It is important and also has potential clinical application. Methods: Exogenous oxidants such as iodine (I2), potassium permanganate (KMnO4) and hydr Read More

Background: The search for new natural or synthetic products with antioxidant activity is commonly based on methods that involve reduction of either 2,2-diphenyl-1-picrylhydrazyl (DPPH) or 2-2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). However, the reported values of the effective concentrations are highly variable, even in controls. Herein, we optimize and validate both methods of determining antiradical Read More

Background: The photo thermal lens microscopy is a technique based on measurement of the temperature rise which is generated in an illuminated matrix because of non-radiative relaxation of absorbed energy from a laser. It is an ideal system for low detection volume measurements in a micro channel. Hence, in this study, a combined microfluidic chip-photo thermal lens microscopy (MFCPTLM) system Read More

Background: Multivariate statistical analyses were used to investigate the mineral contents of wines from the mid-São Francisco River valley, located between the northeastern Brazilian States of Bahia and Pernambuco, with those of wines from Rio Grande do Sul State. Methods: Ten elements (Al, Ba, Ca, Fe, K, Mg, Mn, Na, P, and Zn) were determined by inductively coupled plasma optical emission spectrometry (ICP-O Read More

Background: The adsorption of volatile estragole vapor by various polymer membranes was determined using attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and quartz crystal microbalance (QCM) gas sensor data. Methods: The estragole gas exposure adsorption experiments were selected based on polymer membrane properties: density, double bond saturation, polarity, etc. Results: C Read More

Background: Recently, the use of functionalized metal nanoparticles as colorimetric probes for the detection of a variety of compounds including drugs and pesticide have received considerable attention. Highly sensitive, selective, and cost effective method without any pretreatment of analyte for pharmaceutical analysis is of immense research interest to (bio)analytical / pharmaceutical chemist. Objective: Gold and silv Read More