Anti-Infective Agents - Volume 22, Issue 3, 2024

The success of a dental restoration can be altered by the amount of residual bacteria present under the cavity which over time cause deterioration of adhesive cement by microleakage or secondary caries. Cavity disinfectant application on the cavity walls performs a cleansing action to decrease the bacterial load and improve the longevity of restorations. Although a wide variety of such chemical disinfectants have been Read More

Aim: The study aimed to analyze the prevalence and antibiogram of E. coli isolated from stool sample cultures collected from children below five years of age who were presented with acute diarrhoea in a tertiary care centre. Background: Multidrug-resistant strains of diarrheagenic E. coli remain a major public health concern for greater morbidity and mortality. Antibiotic resistance and susceptibility patterns of E. coli were Read More

Background: Considering the majority of pharmaceutical firms focus on using herbal remedies as an alternative source of essential components, herbal remedies are extremely significant to pharmacological researchers. Spathodea campanulata is one of the members of the Bignoniaceae family. It is popular for its curative properties. Aim: This research aimed to assess the possibility of bioactive elements and antioxidant i Read More

Background: The mortality and morbidity rates in patients caused by fungi are extremely high. 3-4 % of species of fungi like Candida and Aspergillus are responsible for >99% of invasive fungal infections. Aim: The goal of the current work was to use several In-silico methods, such as Pharmacophore modeling and 3D-QSAR, to design New chemical entities (NCEs) that have antifungal activity. Materials & Methods: A da Read More

Background: In different types of microbes, various defense mechanisms have evolved against the commercially available antimicrobial agents with increased resistance. Natural antimicrobial agents of plant origin are better alternatives when an infectious disease arises due to resistant microbial strains. Here, we have evaluated the efficacy of total phenolics and total flavonoids with antioxidant and antimicrobial potentia Read More

Background: The Toll-like receptor-3 (TLR3) ligand Poly(I:C) has been shown to induce a viral aggravation of severe asthma by identifying double-stranded RNA (dsRNA). This study aimed to evaluate the therapeutic role of the TLR3/dsRNA complex inhibitor-calbiochem compound in the treatment of Poly(I:C)-induced viral asthma exacerbations through the ovalbumin- induced asthma model in Swiss albino mice. Methods: Read More

Background and Aim: Lipopolysaccharides (LPS) from Salmonella typhi will attach with Toll-Like Receptor 4 (TLR-4) and trigger an inflammatory response to fight the pathogen. Due to infection, the HMGB1 is produced by immune cells or secreted passively from dead cells. Furthermore, the antimicrobial peptide, cathelicidin was secreted to neutralize and eliminate these pathogens. This study aims to examine the interaction Read More

Background: Emerging antibiotic resistance (ABR) in Proteus spp., especially to third-generation cephalosporins (3GCc), carbapenems, and fluoroquinolones, challenges the treatment outcome and infection prevention. Limited studies pose a knowledge gap between them and ABR. Methods: We investigated the in vitro efficacy of therapeutic options and prevalence of β-lactamase and plasmid-mediated quinolone re Read More