Anti-Infective Agents - Volume 20, Issue 4, 2022

Background: Emergence of drug resistance and severe side effects with current antitubercular drugs urges the development of more efficacious and safer new agents. The present study focused on this direction to develop new hetero-fused pyrimidines as potential antitubercular agents. Objective: The objective of the study was to synthesize and assess the antibacterial and antimycobacterial activity of novel 1,2,4-triazole Read More

Background: Developing new antibacterial and antiviral drugs are considered a significant issue due to the emergence and spread of resistant strains of microorganisms. The COVID-19 pandemic has dramatically increased the need for new broad-spectrum anti-infective agents. Objective: This experimental study aimed to investigate the antibacterial and phagocytic properties of silver-interferon preparation. The combinati Read More

Mucormycosis is the most emerging angioinvasive fungal infection of filamentous fungi of the Zygomycetes class, which, when neglected, causes severe disseminated infection along with significant chances of morbidity and mortality. The diagnosis and treatment remain challenging for the doctors. It has been observed that people who have been suffering from different diseases, such as hematological malignancies and unc Read More

Background: Coronavirus disease 2019 (Covid-19) is caused by a novel coronavirus (SARS-CoV-2) infection, while influenza viruses cause the flu. SARS-CoV-2 and influenza virus co-infection seems to be a real and serious concern. Objective: This study aims to evaluate the clinical features, laboratory investigations, computed tomography scans, and interventions of Covid-19 patients during seasonal influenza. Methods: This Read More

Background: The chemical modification of pyridazinone leads to a potent therapeutic agent. Aims: A series of novel analogues of 4,5-dichloro-6-(substituted-benzyl)-2-(5-mercapto-[1,3,4]- oxadiazol-2-ylmethyl)-2H-pyridazin-3-one have been synthesized. Objectives: The novel synthesized pyridazinone derivatives were docked for possible targets, followed by antimicrobial and antioxidant activities. Methods: The target com Read More

Objective: This study aims to determine the in vitro antioxidant and antimicrobial properties of Nephrolepis biserrata (Sw.) Schott leaf extracts against different microbial strains, including 4 gram-positive bacteria, 4 gram-negative bacteria, 3 yeast, and 4 mould. Methods: The agar well diffusion method examined the antimicrobial activity of Nephrolepis biserrata leaf extracts against test micro-organisms. Additionally, TP Read More

Background: SARS-CoV-2 infection has spread throughout the globe and has become a terrible epidemic. Researchers all around the globe are working to understand the characteristics of coronavirus and are trying to find antiviral compounds as an alternative to vaccines. Objective: The present study has been conceptualized to screen the various metabolites of traditional therapeutic plants that can have crucial antiviral Read More

Background: Mentha piperta L. var peppermint oil is one of the most important essential oil products in the world due to its application in the pharmaceutical, food, and cosmetic industries. Objective: The present study aimed to examine the biological activities, including antioxidant and antimicrobial potentials of oil extracted from peppermint leaves using a solvent extraction method. Methods: The oil extraction was don Read More

Introduction: The purpose of this study was to evaluate the antimalarial, antibacterial, antifungal, antioxidant, and anti-inflammatory properties of Emblica officinalis fruit ethanol extract. Methods: Emblica officinalis fruit extract was prepared using the Soxhlet apparatus at room temperature for 48 hours with 99% ethanol and 1% of double-distilled water. GCMS was used to determine the phytoconstituent profile of an extract of E Read More

Introduction: The study of novel Schiff bases and their metal complexes has achieved enormous attention of inorganic as well as medicinal chemists. Objective: The objective of this study is to study the structural elucidation and antimicrobial screening of 3-formylchromone and 3-aminoquinoline-based Schiff base and their metal complexes. Methods: Cu(II) and Co(II) complexes of 3-((quinolino-3-ylimino) methyl)-4 Read More