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- Volume 20, Issue 5, 2022
Anti-Infective Agents - Volume 20, Issue 5, 2022
Volume 20, Issue 5, 2022
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An Insight into Pyrazole-containing Compounds: Synthesis and Pharmacological Activities
Authors: Harish Kumar, Kushal K. Bansal and Anju GoyalBackground: Heterocyclic scaffolds have gained exceptional devotion in recent years due to their marked utility in the bio-organic field. Among these, pyrazole remains a privileged scaffold as a broad array of medicinally active agents encompass this heterocycle as a core nucleus. Pyrazole is a five-membered, aromatic ring containing two nitrogen atoms at adjacent positions that are readily able to show interactions with nu Read More
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Impact of the Current Scenario and Future Perspectives for the Management of Oral Diseases: Remarkable Contribution of Herbs in Dentistry
Authors: Ashima Ahuja and Sonia SinghBackground: Herbs are the primary feedstock for treating numerous infectious diseases occurring in humans. The herb serves as a potential resource for managing dental disorders by maintaining oral hygiene and reducing the growth of microbes through the use of antimicrobial agents. The body-to-mouth connection helps essential facets that reduce the vulnerability of inflammation and infections in the mouth. The herb Read More
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Novel Methodology for Synthesis and Computational Analysis of Zinc Complexes of Isatin Derivatives and Screening their Biological Activity
Authors: Akriti Goel, Navidha Aggarwal and Sandeep JainBackground: Due to arising threats of microbial infectious diseases in the human population and the development of resistance against therapeutics, novel medicinal agents are required to counteract antimicrobial resistance. Heterocyclic rings, such as indole or pyrrole, have been acknowledged to possess various biological properties, like antimicrobial, anticancer, antiviral, antitubercular, etc., and metals, such as Read More
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In silico Studies of Plant-Derived Bioactive Compounds of Wedelia Species
Authors: Nidhi Rani, Randhir S. Dahiya and Praveen KumarBackground: In India, several types of plants have been researched for the treatment of various ailments. Wedelia species, belonging to the Asteraceae family, is one of the wonder plants that has been utilised in Unani, Ayurvedic, and Homeopathic treatment for a long time. Objective: The components of Wedelia species were investigated in order to create novel powerful anti-fungal drugs with low toxicity and high effic Read More
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Therapeutic Efficacy of Polyherbal Formulation Kabasura kudineer Against Common Viral Fevers - A Perspective Review
Background: COVID-19 viral infection is a worldwide pandemic that created a major concern regarding the need for a suitable drug candidate for viral infections. The entire scientific community is putting up their efforts and research to find a proper cure for this. The traditional Indian Siddha system of medicine is one of the oldest forms of medicine, which includes medicine, Varma, alchemy, yoga, and rejuvenation. Methods: Read More
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An In silico Study of Imidazo[1,2-a]pyridine Derivatives with Homology Modelled F1F0 ATP Synthase Against Mycobacterium Tuberculosis
Authors: Surabhi Jain, Smriti Sharma and Dhrubo J. SenBackground: Field-based 3D-QSAR, homology modelling, molecular docking, and ADMET studies have been carried out to determine the binding mode and drug likeliness profile of imidazo[1,2- a]pyridine derivatives as anti-tubercular agents. Objective: The objective of this study is to design new anti-tubercular agents using field-based 3D-QSAR and molecular docking approaches and to ascertain the binding manner and dru Read More
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Potential of Streptomyces Strains Isolated from Soils as Biocontrol Agents Against Fusarium Species
Background: Fusarium species are significant plant and human pathogens. Current chemical agents against them are limited by their side effects and developed resistance, requiring an alternative way to overcome this problem. Objective: We aimed to assess the inhibitory effects of Streptomyces strains isolated from soil samples against Fusarium species. Methods: Totally 250 samples were collected. Morphological a Read More
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Computational Studies and Biological Evaluation on Synthesized Lead 1,3- diphenyl-4,5-dihydro-1H-pyrazole Moiety as Anti-Infective Agents
Background: Chronic non-communicable diseases were interlinked with inflammation, and infections should respond to the core of major diseases in both acute and chronic conditions. In drug discovery, developing a drug that acts as an anti-infective agent (anti-microbial and antiinflammatory) must be ideal and challenging for managing many chronic diseases. Objective: In this study, six lead pyrazoline hybrids were synthesized Read More
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Chemical Composition and Antioxidant, Anti-Inflammatory and Neuroprotective Properties of Hexane Extracts from the Roots of Centaurea acaulis and Centaurea pullata
Background: In herbal medicine, Centaurea is used in the treatment of many diseases such as dizziness, headaches, etc. It also reduces inflammatory pain and is used to treat liver diseases. The roots of Centaurea acaulis and Centaurea pullata have not yet been studied for biological properties. Objective: The aim of this research was to evaluate the chemical composition and the antiinflammatory, antioxidant and neu Read More
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Synthesis, Characterization, In vitro Antimicrobial Evaluation and Molecular Docking Studies of Pyrazole Based Pyrimidine and Pyrazolone Motifs
Authors: Nisheeth C. Desai, Ashvinkumar G. Khasiya, Bharti P. Dave and Vijay M. KhedkarBackground: In the past few decades, mankind has been suffering from tormented life-threatening infectious diseases caused by multidrug-resistant bacteria. As a result, new antimicrobial classes with distinct modes of action are required to combat multidrug-resistant infections. Objective: The pyrazole-based pyrimidine and pyrazolone motifs were synthesized, characterized, and screened for their antimicrobial a Read More
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Impact of Viral Load Suppression on CD4+ T-Cell Count and BMI Following Combine Antiretroviral Therapy (cART): Preliminary Findings in a Resource Poor Setting
Authors: Olayemi Balogun, Bukhari I. Shuaib, Usman Abdulrasheed Usman and Aminu Abba YusufBackground: Immunological CD4+ T cell gain is representative of an effective response to combined antiretroviral therapy (cART) in HIV-infected persons. Nevertheless, baseline clinical and socio-demographic factors are significant moderators of this response. Objective: This study investigates the impact of viral suppression on immune reconstitution and body mass index (BMI) following ART initiation in Zaria, a reso Read More
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Physicochemical and Therapeutic Properties of Malaysian Stingless Bee Kelulut Honey in Comparison with Yemeni Sidr Honey
Authors: Mohammad A. Al-Kafaween, Abu Bakar M. Hilmi and Hamid A. N. Al-JamalKelulut and Yemeni Sidr honey has been documented to have various therapeutic properties. Investigations associated with the medicinal properties and physicochemical characteristics of Kelulut and Yemeni Sidr honey are growing broadly and receiving raised awareness. This study incorporated and analysed the findings on the biological and physicochemical properties of Kelulut and Yemeni Sidr honey. Kelulut and Y Read More
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