Anti-Infective Agents - Volume 20, Issue 5, 2022

Background: Heterocyclic scaffolds have gained exceptional devotion in recent years due to their marked utility in the bio-organic field. Among these, pyrazole remains a privileged scaffold as a broad array of medicinally active agents encompass this heterocycle as a core nucleus. Pyrazole is a five-membered, aromatic ring containing two nitrogen atoms at adjacent positions that are readily able to show interactions with nu Read More

Background: Herbs are the primary feedstock for treating numerous infectious diseases occurring in humans. The herb serves as a potential resource for managing dental disorders by maintaining oral hygiene and reducing the growth of microbes through the use of antimicrobial agents. The body-to-mouth connection helps essential facets that reduce the vulnerability of inflammation and infections in the mouth. The herb Read More

Background: Due to arising threats of microbial infectious diseases in the human population and the development of resistance against therapeutics, novel medicinal agents are required to counteract antimicrobial resistance. Heterocyclic rings, such as indole or pyrrole, have been acknowledged to possess various biological properties, like antimicrobial, anticancer, antiviral, antitubercular, etc., and metals, such as Read More

Background: In India, several types of plants have been researched for the treatment of various ailments. Wedelia species, belonging to the Asteraceae family, is one of the wonder plants that has been utilised in Unani, Ayurvedic, and Homeopathic treatment for a long time. Objective: The components of Wedelia species were investigated in order to create novel powerful anti-fungal drugs with low toxicity and high effic Read More

Background: COVID-19 viral infection is a worldwide pandemic that created a major concern regarding the need for a suitable drug candidate for viral infections. The entire scientific community is putting up their efforts and research to find a proper cure for this. The traditional Indian Siddha system of medicine is one of the oldest forms of medicine, which includes medicine, Varma, alchemy, yoga, and rejuvenation. Methods: Read More

Background: Field-based 3D-QSAR, homology modelling, molecular docking, and ADMET studies have been carried out to determine the binding mode and drug likeliness profile of imidazo[1,2- a]pyridine derivatives as anti-tubercular agents. Objective: The objective of this study is to design new anti-tubercular agents using field-based 3D-QSAR and molecular docking approaches and to ascertain the binding manner and dru Read More

Background: Fusarium species are significant plant and human pathogens. Current chemical agents against them are limited by their side effects and developed resistance, requiring an alternative way to overcome this problem. Objective: We aimed to assess the inhibitory effects of Streptomyces strains isolated from soil samples against Fusarium species. Methods: Totally 250 samples were collected. Morphological a Read More

Background: Chronic non-communicable diseases were interlinked with inflammation, and infections should respond to the core of major diseases in both acute and chronic conditions. In drug discovery, developing a drug that acts as an anti-infective agent (anti-microbial and antiinflammatory) must be ideal and challenging for managing many chronic diseases. Objective: In this study, six lead pyrazoline hybrids were synthesized Read More

Background: In herbal medicine, Centaurea is used in the treatment of many diseases such as dizziness, headaches, etc. It also reduces inflammatory pain and is used to treat liver diseases. The roots of Centaurea acaulis and Centaurea pullata have not yet been studied for biological properties. Objective: The aim of this research was to evaluate the chemical composition and the antiinflammatory, antioxidant and neu Read More

Background: In the past few decades, mankind has been suffering from tormented life-threatening infectious diseases caused by multidrug-resistant bacteria. As a result, new antimicrobial classes with distinct modes of action are required to combat multidrug-resistant infections. Objective: The pyrazole-based pyrimidine and pyrazolone motifs were synthesized, characterized, and screened for their antimicrobial a Read More

Background: Immunological CD4+ T cell gain is representative of an effective response to combined antiretroviral therapy (cART) in HIV-infected persons. Nevertheless, baseline clinical and socio-demographic factors are significant moderators of this response. Objective: This study investigates the impact of viral suppression on immune reconstitution and body mass index (BMI) following ART initiation in Zaria, a reso Read More

Kelulut and Yemeni Sidr honey has been documented to have various therapeutic properties. Investigations associated with the medicinal properties and physicochemical characteristics of Kelulut and Yemeni Sidr honey are growing broadly and receiving raised awareness. This study incorporated and analysed the findings on the biological and physicochemical properties of Kelulut and Yemeni Sidr honey. Kelulut and Y Read More