Synthesis and Biological Evaluation, Structural Elucidation, Thermogravimetric Analysis, X-Ray Diffraction Studies of a Schiff Base Derived from 3-formylchromone and 3-aminoquinoline and their Cu(II) and Co(II) Complexes

Introduction: The study of novel Schiff bases and their metal complexes has achieved enormous attention of inorganic as well as medicinal chemists. Objective: The objective of this study is to study the structural elucidation and antimicrobial screening of 3-formylchromone and 3-aminoquinoline-based Schiff base and their metal complexes. Methods: Cu(II) and Co(II) complexes of 3-((quinolino-3-ylimino) methyl)-4H-chromen-4- one ligand were synthesized and characterized by elemental analysis, molar conductivity measurement, infrared, UV-Visible, ¹H NMR spectral studies, thermogravimetric analysis, and powder X-ray diffraction studies. Results: Antibacterial activity of synthesized compounds were screened against Klebsiella pneumoniae, Staphylococcus aureus, and Proteus vulgaris, and antifungal activity was screened against fungi Candida albicans and Aspergillus niger. Schiff base ligand and their Cu(II) and Co(II) complexes revealed significant antibacterial and antifungal activity against tested strains. Octahedral geometry of metal complexes was proven by analytical, physical, and spectral data. Conclusion: In this present work, novel Schiff base 3-((quinolino-3-ylimino) methyl)-4Hchromen- 4-one and its Cu(II) and Co(II) complexes revealed promising antibacterial and antifungal activities.