Anti-Infective Agents - Volume 16, Issue 1, 2018

The WHO has estimated that one-fourth of the world's population harbor a latent infection by MTB, and around 100-200 million individuals eventually develop an active TB. To make matters worse, drug-resistant MTB as well as the co-infection between MTB and HIV has further aggravated the mortality and spread of this disease. The quinolones have contributed an increasingly important chapter to the evolution Read More

Background: The problem of bacterial resistance of Mycobacterium tuberculosis should be solved by seeking for alternative substances that potentially inhibit the growth or kill the bacteria. Ganoderma lucidum is one type of fungus which is potential to be an antimicrobial agent. This study aimed to determine the potential of G. lucidum on inhibiting the growth of multidrug-resistant bacteria of M. tuberculosis in vitro. Read More

Objectives: Pharmacokinetics of dapaconazole and inhibition of cytochrome P450 family 51. Methods: Pharmacokinetics of dapaconazole, a novel imidazolic antifungal compound, was studied in male beagle dogs following intravenous (1, 2 and 20 mg/kg) and oral (20 mg/kg) administration. Results: Oral bioavailability was calculated to be 97.3%. The elimination half-life (t½) after intravenous administration was 2.1-2.5 h, the Read More

Background: According to global eradication initiative program, poliomyelitis was eradicated all over the world except Pakistan and Afghanistan due to some challenges like misconceptions, non-compliances, political and militancy issues, etc. Objective: This study quantitatively evaluates the knowledge, attitude and perception of general public regarding polio and its vaccination in district Abbottabad and Mansehra, KPK, Pakis Read More

Background: The increasing predominance of microbial resistance towards available antimicrobial drugs urges the need to develop novel antimicrobial agents that will be effective against resistant bacteria and fungi. Objective: A series of 3-(benzothiazol-2-yl)-2-(4-substituted phenyl) thiazolidin-4-one derivatives were synthesized as pharmacophore hybrid of benzothiazole and thiazolidin-4-one moieties as exclusive ant Read More

Background: Today infectious microbial diseases are causing complications world-wide, since resistance to a number of antimicrobial agents (β-lactam antibiotics, macrolides, quinolones, and vancomycin). A range of clinically important species of microorganisms has become a significant health problem globally. Methods: In quest of new antimicrobial agents with enhanced potency, a series of 6-aryl-3-[(2,3,4- substituted) Read More

Background: Chemotherapy of schistosomiasis by certain drugs is impractical due to the resistance of Schistosoma larvae to schistosomiasis drugs after long treatment period. The aim of this work is to monitor Schistosoma mansoni infection on mice livers after treatment with the ethanolic extract of Justicia spicigera areal parts and the herbal antishistosomal drug (Mirazid); the oleo-resin extract from Myrrh of Commiphora Read More

Introduction: In the last two-three decades, antimicrobial infections have developed extreme multiple drug-resistance and the appearance of these resistant strains is one of the biggest threats to global health. The benzothiazole moiety is of interest to many researchers on the grounds that they constitute a vital class of heterocyclic compounds exhibiting enormous chemotherapeutic activities. In the drug design aspect, structure Read More

Introduction: A series of seventeen 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea derivatives (5a-8d) were synthesized and characterized by physical and spectral data (IR, 1H NMR, and mass spectroscopy) and evaluated for their antibacterial and antifungal activities against various pathogenic and non-pathogenic microorganisms. Some of the synthesized compounds showed promising antibacterial and antifungal ac Read More