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2000
Volume 16, Issue 1
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Introduction: A series of seventeen 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea derivatives (5a-8d) were synthesized and characterized by physical and spectral data (IR, 1H NMR, and mass spectroscopy) and evaluated for their antibacterial and antifungal activities against various pathogenic and non-pathogenic microorganisms. Some of the synthesized compounds showed promising antibacterial and antifungal activities. Results and Discussions: Many of the tested compounds were found to be significantly active against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacterial strains (Escherichia coli, Salmonella typhi, Klebsiella pneumoniae and Pseudomonas aeruginosa), among which compounds 5a, 5b, 6a, 6b, 7a, 7b, 8a and 8b showed the maximum anti-bacterial activity but less effective than the standard ciprofloxacin. Almost all compounds from 5a-8d showed moderate activity against fungal strains like Candida albicans and Aspergillus niger.

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/content/journals/aia/10.2174/2211352516666180307155830
2018-04-01
2025-07-11
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