Anti-Infective Agents - Volume 16, Issue 2, 2018

Tuberculosis, an ancient infectious disease caused by Mycobacterium tuberculosis, ranks as one of the top ten killers worldwide. The limited number of validated targets and scarce therapeutic options demand that renewed efforts should be made to identify tuberculosis drugs with novel mechanisms of action. To this end, mycobacterial DNA might represent a potential target for the development of effective anti-tubercul Read More

Human cytomegalovirus (HCMV) is a beta herpesvirus that inflicts an active infection in the fetus and immunosuppressive patients. The virus encodes many proteins that work together with cellular factors to achieve virus replication. In addition to vaccines, antiviral drugs can be deployed to manipulate how the virus replicates and minimize its pathogenicity. The five antiviral drugs approved by the Food and Drug Administr Read More

Background: Despite recent advances in burns management and antimicrobial chemotherapy, infection continues to be a tricky in the burns. Treatment of a burn infection especially in case of multi-drug resistant Pseudomonas aeruginosa is a big challenge in clinics and needs novel strategies. Miscarriage of the current treatment strategies to control several cases of burns infections, the systemic and local toxicity th Read More

Background: Multidrug Resistance (MDR) of microorganisms is the biggest pharmacological challenge, despite plenty of modern antibiotics. Obviously, new classes of antimicrobial drugs against MDR pathogens need to be developed. Objective: This work aimed to investigate the antibacterial properties of the novel copper-based complex - bisimidazoles - (1,10) phenanthroline cuprum (II) dichloride - [CuPhenIm2]C Read More

Introduction: A series of (R)-(-)-4-Phenyl-2 oxazolidinone based azetidinones (4a-i) were synthesized from the reaction of (2-Oxo-4-phenyl-oxazolidin-3-yl) acetic acid with aromatic imines (3a-i) in the presence of Thionyl chloride and Triethylamine as a base. Methods: The transformation proceeds through the formation of acid chloride to ketene which finally forms the azetidinones through [2+2] cycloaddition with aromati Read More

Introduction: When environment polluted by complex petrochemical contaminants then prospective for biological treatment is needed. Methods: Biosurfactants exhibit biodegradability and anti-microbial properties hence efficacy of production and kinetics of in situ rhamnolipid production by Pseudomonas aeruginosa and lipopeptide production by Bacillus subtilis was carried out in a batch process. The need of the specific gro Read More

Background: Two series of Guanidinyl benzothiazole and benzothiazole diamide derivatives were synthesized and screened for their anti-mycobacterial activity and cytotoxicity on cancer cell lines. Methods: The anti-mycobacterium study indicates that all the synthesized benzothiazole compounds were appreciably active and some of the compounds have MIC values lower than the standard drugs. Benzothiazoleguanidi Read More

Background: The prevalence of pulmonary tuberculosis infections had increased among the type 2 Diabetes Mellitus (DM) patients in India, although the biological basis underlying this susceptibility remains poorly characterized. Based on the symptom's, chest X-rays and their correlation with clinical and diagnostic parameters, we had suspected diabetic-tuberculosis co-infections. As Chest XRay plays a vital role in the iden Read More

Background: Glycyrrhiza glabra (liquorice) has been extensively used since ancient Egypt, Greek and Roman, and is an important herb in traditional Chinese medicine. Its major compound, Glycyrrhizin (GL) possesses multiple pharmacological activities, such as anti-virus waiting for exploration indepth. Objective: The aim of this research is determining the antiviral mechanisms of Stronger Neo-Minophafen C (SNMC), an establish Read More

Background: Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that O. viverrini and C. sinensis, also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by F. hepatica Read More