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- ISSN: 0929-8665
- E-ISSN: 1875-5305
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Bactericidal and Hemolytic Activities of Synthetic Peptides Derived from Granulysin
- Source: Protein and Peptide Letters, Volume 17, Issue 4, Apr 2010, p. 517 - 521
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- 01 Apr 2010
Abstract
Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 μM. In concentrations of up to 50 μM, Gr-1 and Gr2 didn't exceed 30% of hemolysis.
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