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2000
Volume 13, Issue 3
  • ISSN: 0929-8665
  • E-ISSN: 1875-5305

Abstract

A common mechanism of conformational changes and pathological aggregation of proteins associated with amyloid diseases remains to be proven. High pressure is emerging as a new strategy for studying aspects of amyloid formation. Pressure provides a convenient means to populate and characterize partially folded states, which are thought to have a key role in assembly processes of proteins into amyloid fibrils. High pressure can also be used to dissociate aggregates and amyloid fibrils or on the opposite to generate such species.

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/content/journals/ppl/10.2174/092986606775338371
2006-03-01
2025-06-12
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