Pharmaceutical Nanotechnology - Volume 11, Issue 4, 2023

Nanomaterials are emerging as an innovative and efficient instrument for the transport and cellular translocation of therapeutic compounds, namely, biopharmaceuticals. The use of nanoparticles as drug carriers in the healthcare industry, for instance, in several applications, with drug delivery being among the most significant. These nanomaterials are adaptable and have qualities that are good for delivering compoun Read More

Background: Bioavailability is the dissimilarity between the total amount of drug exposure to a person and the actual dose received by his body. The difference in bioavailability between formulations of a given drug can have clinical implications. Methods: Poor aqueous solubility, inappropriate partition coefficient, high first-pass metabolism, narrow absorption window, and acidic pH of the stomach are the main reasons behind t Read More

Background: Synthesizing a green source that has antimicrobial activity in nanoparticles is a novel and exciting approach to pharmaceutical science with promising results. Objective: Green-silver nanoparticles (G-AgNPs) were evaluated for their antimicrobial action on drugresistant pathogens. Methods: Lemon, black seeds, and flax were selected as green sources to synthesize nanoparticles formed with silver. Physical and che Read More

Background: Ketoconazole is an imidazole ring containing antifungal agent used in the treatment of systemic fungal infections. It acts by blocking the synthesis of ergosterol, an essential component of the fungal cell membrane. Objective: The purpose of this work is to construct skin targeting ketoconazole nanostructured lipid carriers (NLCs) loaded hyaluronic acid (HA) modified gel to minimize side effects and provide a control Read More

Objective: Aluminum phosphide (AlP) as an effective pesticide may contribute to oxidative stress and adversely influence sperm parameters. This study aimed to investigate the protective role of curcumin and nanocurcumin on oxidative damage in the testis of rats with AlP toxicity. Methods: A total of 42 adult male Wistar rats were equally randomized into the following study groups (n = 7): Control, Control+Curcumin, Control+ Read More

Aims: This study aimed to prepare and evaluate the physicochemical and anticancer properties of cisplatin and curcumin-loaded mesoporous silica nanoparticles (Cis-Cur-MSNs). Background: In recent years, combination treatment has attained better outcomes than monotherapy in oncology. Cis-Cur-MSNs were prepared by precipitation technique. Objective: The objective of the present study was the evaluation of the physicoc Read More

Background: A drug with poor water-solubility, like Dexamethasone acetate, can present lower bioavailability conventional for pharmaceutical formulations, and the presence of polymorphs in the raw material can lead to drug quality problems. Objective: In this study, nanocrystals of dexamethasone acetate were synthesized by high pressure homogenizer (HPH) method in surfactant poloxamer 188 (P188) solid disper Read More

Introduction: Titanium-based implants are widely used due to their good biocompatibility and high corrosion resistance. Infections after implant placement are the main reason for the failure of implant treatment. Some recent studies have also shown that microbial contamination can occur at the implant-abutment level in implants with healthy or diseased surrounding tissue. The purpose of this study is to investigate the anti Read More

Introduction: For the long-term success of implant treatment, prevention of biological complications, including pre-implant diseases, plays an important role. The use of antimicrobial coatings is one of the prosperous methods in this field. The aim of this study is to evaluate the antimicrobial effects of healing abutments coated with gelatin-curcumin nanocomposite. Methods: This study included 48 healing abutments in the for Read More