Pharmaceutical Nanotechnology - Volume 11, Issue 1, 2023

Insulin is a peptide hormone released by pancreatic beta cells. An autoimmune reaction in diabetes mellitus type 1 causes the beta cells to die, preventing insulin from being produced or released into the bloodstream; that impacts 30 million people globally and is linked to shortened lifespan due to acute and chronic repercussions. Insulin therapy aims to replicate normal pancreatic insulin secretion, which includes low levels o Read More

Recent advances in electrospinning have transformed the process of fabricating ultrafine nano-fiber scaffolds with side benefits to drug delivery systems and delivery systems in general. The extremely thin quality of electrospun nanofiber scaffolds, along with an effective area of high specificity and a stereological porous structure, capacitates them for the delivery of biomolecules, genes, and drugs. Accordingly, the pr Read More

Polyacrylic and polymethacrylic acids, in combination with polymers such as polyacrylamide, provide the ability for controlled and sustained drug delivery since they represent pHand temperature responsiveness. In addition, the synthesis techniques can be used to develop a higher level of supramolecular structures as the interpenetrating polymer networks - as bulk hydrogels or micro-/nanogels. They can provide the oppor Read More

Background: Various types of nano-formulations are being developed and tested for the delivery of the ocular drug. They also have anatomical and physiological limitations, such as tear turnover, nasal lachrymal waste, reflex squinting, and visual static and dynamic hindrances, which pose challenges and delay ocular drug permeation. As a result of these limitations, less than 5% of the dose can reach the ocular tissues. Obj Read More

Background: Herbal preparations with low oral bioavailability have a fast first-pass metabolism in the gut and liver. To offset these effects, a method to improve absorption and, as a result, bioavailability must be devised. Objective: The goal of this study was to design, develop, and assess the in vivo toxicity of polyherbal phytosomes for ovarian cyst therapy. Methods: Using antisolvent and rotational evaporation procedures, phyt Read More

Background: Formulations of eprosartan mesylate with a surfactant, like Kolliphor HS 15, an oil phase like Labrafil M 1944 CS, and a cosurfactant Transcutol HP by employing a liquid self-microemulsifying drug delivery system (SMEDDS) after screening several vehicles have been studied. Objective: This study aimed to prepare a liquid self-microemulsifying drug delivery system for increasing the solubility and bioavailability Read More

Background: Paccai eruvai formulation has been widely used in traditional Siddha practice to treat ulcerous wounds due to the content of potentially active compounds. Objective: The present study aimed to determine the enhancement potency of wound healing of nanogels containing Paccai eruvai in an incision and excision wound models. Methods: Paccai eruvai nanogel was synthesized using the high-energy milling m Read More

Introduction: In recent years, plant-mediated synthesis of silver nanoparticles has evolved as a promising alternative to traditional synthesis methods. In addition to producing silver nanoparticles with diverse biomedical potential, the biosynthesis approach is known to be inexpensive, rapid, and environmentally friendly. Objective: This study was aimed at synthesizing silver nanoparticles using ethanolic stem and root b Read More

Background: Delivery systems with low immunogenicity and toxicity are believed to enhance the efficacy of specific targeted drug delivery to cancer cells. Exosomes are potential natural nanosystems that can enhance the delivery of therapeutic agents for targeted cancer therapy. Objective: This study provides a precise effect size of exosomes as nanovesicles for in vitro delivery of anticancer agents. Methods: In thi Read More