Mini-Reviews in Organic Chemistry - Volume 4, Issue 2, 2007

Indole benzylic stereocenters are molecular frameworks largely present in natural occurring compounds, with their absolute configuration being of key importance in determining the biological activity of the entire molecule. In this context, the development of new catalytic asymmetric strategies for their preparation is a research area of astonishingly rapid growth by means of organic as well as organometallic catalysts. Here, an Read More

In the paper selected examples of cavitands are presented showing their binding properties. In the first part cavitands with one or two extended walls are described, the second part concerns deep cavitands, and in the third part examples of cavitands forming open capsules are given.

This review provides a discussion of developments in heteroatom-containing, carbon-bridged calixarene and thiacalixarene. These compounds are described with regard to their syntheses and inclusion properties.

The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene, oxazole, amide and ester functionality. The chemistry and biology of these valuable antimicrobial agents is covered.

Various chemistries could be accessed from the aromatic substrates containing CF3 functionality that is conjugated with the ionizable NH, OH or CH groups. The suggested mechanism involves formation of the quinone methide intermediate. It is generally accepted that these reactive species can be viewed as either C1 or C3X (X = N or CH2) synthone. Their reactions in situ with diverse electrophiles yield an array of [6,6]-fused or Read More